Amyloid-β (Aβ) oligomers are recognized as the primary neurotoxic agents in Alzheimer's disease (AD). Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline in AD. Nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in redox activities in the m...

The sites to which valproic acid and its main unsaturated metabolites (2-en-2-propyl pentanoic acid and 4-en-2-propyl pentanoic acid) bind to on human albumin were investigated by (1) measuring their ability to displace the fluorescent probes warfarin and dansylsarcosine and (2) by assessing the...

IntroductionProgesterone receptors (PRs) are present in many breast tumors, and their levels are increased by certain endocrine therapies. They can be used as targets for diagnostic imaging and radiotherapy.

Anabolic steroids are used as doping agents in sports. Notwithstanding the total EC ban, they are also used as growth promoters in animal production. The detection of anabolic steroids in the urine of untreated persons due to the consumption of contaminated meat has been described earlier. This ...

Anabolic androgenic steroids (AAS) are synthetic testosterone derivatives which undergo extensive metabolism in man. Differences in the excretion of phase II metabolites are strongly associated with inter-individual and inter-ethnic variations. Sulfate metabolites have been described as long-ter...

Advantame (N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1-methyl ester, monohydrate), an N-substituted analogue of aspartame, has been developed as a high-intensity sweetener. It is approximately 100 and 20,000 times sweeter than aspartame and sucrose, respectively. I...

The article presents the study of psycho- and neurotropic properties of novel 3-(N-R,R′-aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo. The research was carried out using the open field test, elevated plus maze, rotarod test, tail suspension test, passive avoidance test after scopolamine-indu...

Advantame (N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1-methyl ester, monohydrate), an N-substituted analog of aspartame, has been developed as a high-intensity sweetener. Groups of 4 dogs of each sex were treated at 0, 2000, 10,000, or 50,000 ppm of advantame in th...

Two Mannich bases namely, N-[(4-methoxyphenyl)(morpholin-4-yl)methyl]acetamide (MMPA) and N-[morpholin-4-yl(phenyl)methyl]acetamide (MPA) were synthesized and their influence on the inhibition of corrosion of mild steel in 1.0 M H2SO4 was investigated by weight loss, potentiodynamic polarization...

The reaction between o-hydroxybutyrophenone and tris(2-chloroethyl)amine gave two analogues (II, V) of the well-known local anesthetic ketocaine (I). Compounds II and V showed interesting antitumor activity in mice implanted with Ehrlich ascites tumor cells (% T/C = 149 at 5 mg/kg and 171 at 50 ...

Cardiac stem cells are vulnerable to inflammation caused by infarction or ischemic injury. The growth factor, erythropoietin (Epo), ameliorates the inflammatory response of the myocardium to ischemic injury. This study was designed to assess the role of Epo in regulation of expression and activa...

Natural products are important sources of chemical diversity leading to unique scaffolds that can be exploited in the discovery of new drug candidates or chemical probes. In this context, chemical and biological investigation of ferns and lycophytes occurring in Brazil is an approach adopted by ...

A series of complexes [(4,4′-diMe-2,2′-bpy)2Zn2Eu2(NO3)4(naphac)6] (1), [(4,4′-dtb-2,2′-bpy)2Zn2Ln2(NO3)2(naphac)8] Ln = Eu (2), Tb (3), [(Py)2Zn2Ln2(naphac)10] Ln = Eu (4), Nd (5), Gd (6), Tb (7), Dy (8), [(Py)2Zn2Tm2(NO3)2(naphac)8] (9) (where naphac is the anion of 1-naphthylacetic acid, ...

Ozonization of naphthacene (I) with one molar equivalent of ozone gave 5,12-naphthacenequinone (II). Further, I and II absorb, respectively, three and two molar equivalents of ozone to yield, presumably via Criegee's zwitterion (III), an unstable, probably monomeric ozonide (IV) in inert so...

5,12-Naphthacenequinone (5,12-NpQ) single crystal and naphthacene (Np)-doped 5,12-NpQ mixed crystal have been prepared by crystallization from solution and characterized by X-ray diffraction analysis. Compared with the 5,12-NpQ single crystal, there is no obvious change occurring to the 5,12-NpQ...

Continuous-wave time-resolved EPR (cw-TREPR) and pulsed electron nuclear double resonance (ENDOR) studies have been carried out to clarify the electronic structure of the lowest excited triplet (T1) state of 5,12-naphthacenequinone (5,12-NpQ) as well as 1,4-anthraquinone (1,4-AQ) and 6,13-pentac...

Efficient control of ion homeostasis and nitrogen (N) metabolism contributes to the salt tolerance in crops. However, limited information is available on the contribution of ion homeostasis and N metabolism regulation towards salt tolerance in sweet potato (Ipomoea batatas L.) cultivars at adven...

α-Fluoro-, α-chloro and α-bromo C3-C6 carboxylic acids were separated efficiently into their enantiomers, after conversion into tert.-butylamides, on a whiskerwalled glass capillary column (40 m x 3.5 mm I.D.) coated with (R)-N-lauroyl-α-(1-napththyl)ethylamine. The resolution coefficient (α...

There are reasons to believe that the galanin neuropeptide family could include more than the two hitherto known members (galanin(1-29) and galanin-like peptide), such as the existence of at least three galanin receptors and the fact that synthetic short-chain homologues have effects and binding...

Despite emerging new therapeutic opportunities, cancer is still a major health problem and a leading cause of death worldwide. Breast tumors are the most frequently diagnosed female malignancies, and the triple-negative subtype is associated with poorer prognosis and lower survival rates than ot...