Diseases of the skin, hair, nails and mucosa can appear as flesh-colored lesions or may present as any of the colors of the visual spectrum. Diseases associated with blue (or shades of blue) discoloration represent a unique group of conditions that occur de novo or as a reaction to either a topi...

BackgroundInhibitors for signal transducer and activator of transcription 3 (STAT3), Stattic, BP-1-102, and LLL12 significantly induce apoptosis in transformed Ba/F3 cells expressing an oncogenic fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) that induces the activation of ST...

In this study, Deep Eutectic Solvents (DESs) were utilized for ultrasound-assisted emulsification liquid phase microextraction (UA-ELPME) of Patent Blue V in syrup and water samples. Patent Blue V in sample solution of pH 4.0 was extracted into DES phase prepared from choline chloride and phenol...

A new vortex-assisted supramolecular solvent microextraction based on solidification of floating drop (VA-SSM-SFD) has been developed for preconsentration and spectrophotometric determination of inorganic arsenic (iAs) species in various water samples. The method is based on the formation of ars...

A toxicologic and dermatologic review of (5Z)-2,6-dimethylocta-3,5-dien-2-ol when used as a fragrance ingredient is presented.

Hybrid molecules based on a number of steroids (cholesterol, pregnenolone, androsterone) and 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid linked via mono- and diethylene glycol spacers were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using cat...

Synthetic analogues of natural 5Z,9Z-dienoic acids - hybrid molecules based on the oximes of cholesterol, pregnenolone, and androsterone with 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid - were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using...

The treatment of 2-bromo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone (1) with pyridine, 2-methylpyridine or 4-methylpyridine afforded their corresponding pyridinum bromides 3a–c. The latter salts reacted with activated acetylene to give the corresponding indolizine derivatives 6a–c. Imidaz...

Here we report on the design and synthesis of several heterocyclic analogues belonging to the 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol series of molecules. Compounds were subjected to [3H]spiperone binding assays, carried out with HEK-293 cells expr...

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine molecular fragments derived from known dop...

Berberrubine (BRB), the active metabolite of berberine (BBR), possesses various pharmacological activities. In this study, we found BRB showed not only a stronger lipid-lowering effect than berberine but also a specific nephrotoxicity in mice fed with high fat diet (HFD). To explore the underlyi...

Berberrubine has been synthesized by microwave assisted selective demethylation of berberine. The high selectivity observed in this reaction has been explained and justified by means of computational calculations using Density Functional Theory (DFT) and Natural Resonance Theory (NRT). The exist...

Berberrubine is an isoquinoline alkaloid isolated from Berberis vulgaris L, and it is readily derived from berberine. In this study, a sensitive and selective ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of berberrubine in rat plasma ...

Berberrubine, an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects. This study aimed to investigate the metabolic profile of berberrubine in vivo. Therefor...

As a part of an ongoing medicinal chemistry effort to identify inhibitors of the Hepatitis C Virus RNA replication, we report here the synthesis and biological evaluation of 9-deaza- and 7,9-dideaza-7-oxa-2′-C-methyladenosine. The parent 2′-C-methyladenosine shows excellent intracellular inhib...

This study evaluates the ability of FeII–oxalate complexes for the generation of OH through oxygen reduction and the oxidative degradation of aquatic pollutants under dark aerobic conditions (i.e., with oxygen but without light). The degradation of 4-chlorophenol (4-CP) was rapid in the mixture...

The electrochemical behaviour of the μ-oxo complexes [Fe2III,IIIO(L)4(H2O)2]4+ (L=2,2′-bipyridine (bpy, 1) and (−)4,5-pinene-2,2′-bipyridine (pb, 2)) has been investigated in CH3CN. Since some aqua substitution by CH3CN can occur (although, it is not demonstrated clearly) [Fe2III,IIIO(L)4(S)2...

The electrode processes of tris(2,2′-bipyridine)iron(II) and tris(2,2′-bipyridine)iron(III) complexes at the rotated platinum electrode and the dropping mercury electrode (dme) in acetonitrile solutions have been investigated by the measurement of current/potential curves, dc and ac polarogram...

From isopiestic measurements, hydration constants of the perchlorate ion in nitrobenzene solution of Fe(phen)3(ClO4)2 or Fe(bipy)3(ClO4)2 were estimated using five models, and compared with each other to obtain the best-fit model. We conclude that the mono- and di-hydrate model is the most reaso...

Mössbauer studies at 81 and 295°K and magnetic susceptibility measurements at 80–315°K were used for further characterization of a number of ferrous and ferric chelates with 2,2′-bipyridine N-oxide(N-bipyO) and 1,10-phenanthroline N-oxide (N-phenO), exhibiting room temperature magnetic momen...