The 1:1 complex of Co(ClO4)2 with the H2O-insoluble tridentate 2,6-di(1H-4,5,6,7-tetrahydroindazol-3-yl)pyridine (H21) was found to be an excellent catalyst for the hydrolysis of para-nitrophenyl acetate in aqueous buffers over the pH 7.05–7.90 range, with an estimated second-order rate constan...

Two new three-dimensional cobalt(II) coordination polymers [Co2(cptpy)2(ox)]n (1) and [Co3(cptpy)2(suc)2(H2O)]n (2) (Hcptpy = 4′-(2-carboxyphenyl)-4,2′:6′,4″-terpyridine, H2ox = oxalic acid, H2suc = succinic acid) have been synthesized under hydrothermal conditions and characterized by eleme...

Systematic determinations of electrical conductivities of sodium salts of semisynthetic penicillins, oxacillin, cloxacillin, dicloxacillin and nafcillin in the 278.15 K to 313.15 K temperature range are reported. These conductivities are examined by applying the Quint–Viallard conductivity equa...

BackgroundStudies performed since 1990 on samples of at least 30 subjects with a documented IgE-mediated hypersensitivity to penicillins have found a rate of positive responses to allergy tests with cephalosporins ranging from 0% to 27%.

Piperacillin is a broad spectrum beta-lactam antibiotic used in combination with tazobactam for hospital-related bacterial infections. The reconstituted solutions must respect the sub-visible and visible particles specifications. It was claimed that the reformulation containing EDTA/sodium citra...

Aqueous two-phase systems are useful for separating biological materials. In this study, the phase diagram of the ternary system of choline chloride, K2HPO4 and water was determined at 298.15 K and 0.1 MPa. In this regard, the binodal curves between the single liquid phase, liquid-liquid two-pha...

Even with the emergence of antibiotic resistance, penicillin and the wider family of beta-lactams have remained the single most important family of antibiotics. The periasmic/extracytoplasmic targets of penicillin are a family of enzymes with a highly conserved catalytic activity involved in the...

Nanostructured [email protected]2-Penicillin was synthesized from high-purity Ag0 NPs with a mean particle size of about 10 nm produced by electromagnetic levitation gas condensation (ELGC) method. The silver and penicillin contents of the synthesized nano-antibiotic were about 34 wt% and 2.5 wt...

Penicillin acylase is commonly used to produce the medical intermediates of 6-Aminopenicillanic acid (6-APA) and 7-Aminodesacetoxycephalosporanic acid (7-ADCA) in industrial process. Nowadays, Penicillin G acylase (PGA) has been widely applied for making pharmaceutical intermediates, while penic...

BackgroundTen percent of the population claims an allergy to penicillin, but 90% of these individuals are not allergic. Patients labeled as penicillin-allergic have higher medical costs, longer hospital stays, are more likely to be treated with broad-spectrum antibiotics, and develop drug-resist...

Establishment of the key contributors to the environmental burden of a bioprocess at the early design stage provides opportunity to inform the holistic optimization of the process. Here, the production of penicillin V sodium salt by Penicillium chrysogenum is analyzed in terms of material and en...

Biochar is widely used as adsorbent and catalyst carrier. Penicillin V Potassium residue (PVPR) as a hazardous waste with high organic content has the great potential to produce biochar. The adsorption performance and loading capacity of biochar largely depend on the pore structure, surface area...

Ligand-exchange micellar electrokinetic capillary chromatography was used for the chiral resolution of underivatized and dansyl amino acid enantiomers simultaneously. The separation was achieved by chiral copper(II)–l-valine complexes incorporated in micelles of sodium dodecyl sulfate (SDS). Th...

Chiral selector-functionalized magnetic microspheres have significantly potential in the recognition and separation of chiral compounds. In this work, novel chiral selector-functionalized magnetic microspheres (l[email protected]) were achieved by grafting l-valine (l-Val) on polyamidoamine (PAM...

The effects of solvent and impurity on the crystal habit of 11α-hydroxy-16α, 17α-epoxyprogesterone (HEP) grown from solution were studied by scanning electron microscope. Long prismatic crystals were produced when HEP was crystallized from pure acetone and N, N-dimethylformamide, while blocky...

After incubation of [7-3H]-16-dehydroprogesterone with the liver microsomal fraction of male Wistar rats, two radioactive metabolites were isolated and subsequently identified by gas liquid chromatography-mass spectrometry (g.l.c.-m.s.) as 16α,17-epoxy-3β-hydroxy-5α-pregnan-20-one and 16α,17...

Seven steroid epoxides were prepared from 5α-pregn-2-en-20-one and 5α-pregn-3-en-20-one and their side-chain derivatives. All compounds were tested in vitro for binding to γ-aminobutyric acid (GABAA) receptor, some of them also in vivo for anticonvulsant action.2α,3α-Epoxy-5α-pregnan-20-on...

Human Diphtheria toxin-like ADP-ribosyltranferases (ARTD) 10 is an enzyme carrying out mono-ADP-ribosylation of a range of cellular proteins and affecting their activities. It shuttles between cytoplasm and nucleus and influences signaling events in both compartments, such as nuclear factor kapp...

Metabolic studies with hepzidine maleate, labelled in two positions with 3H and 14C, respectively, showed that in rats, over 50 per cent of an orally administered dose of hepzidine maleate (10 mgkg) is hydrolysed before absorption. The nonhydrolysed part of the dose is absorbed to a large extent...

Red phosphorus reacts with 4-tert-butoxystyrene in KOH/DMSO system to afford (depending on the reaction conditions) tris(4-tert-but- oxyphenylethyl)phosphine oxide (48% yield) and/or 4-tert-butoxyphenylethylphosphinic acid (30% yield). The treatment of these products with aqueous HCl (45 °C, 5 ...