Amberlite IRA402 OH, a gel-type, polystyrene/divinylbenzene, strongly basic anion exchanger containing quaternary ammonium groups, was used as the macromolecular support for copper(II) compounds. The inorganic deposit was introduced into the anion exchanger structure in two steps conducted batch...

In this study, quaternary ammonium functionalized-silica gel was synthesized for nitrate removal using dimethyl dodecyl[3-(trimethoxysilyl)propyl] ammonium chloride (DMDAC) as a quaternary ammonium silane coupling agent, which was grafted to silica gel to obtain the DMDAC-silica gel. Batch exper...

Using the available structural information of the chemokine receptor CXCR4, we present hit finding and hit exploration studies that make use of virtual fragment screening, design, synthesis and structure-activity relationship (SAR) studies. Fragment 2 was identified as virtual screening hit and ...

Complex formation between Cu(II) and human and bovine β-casomorphin heptapeptides, Tyr-Pro-Phe-Val-Glu-Pro-Ile and Tyr-Pro-Phe-Pro-Gly-Pro-Ile, respectively, was investigated by pH potentiometry and spectroscopic (CD, EPR and electronic absorption) techniques. The results showed the critical im...

The release of β-casomorphin-7 (BCM-7) in bovine milk with β-casein genetic variants A1, A2, F and I was assessed. An ex vivo gastrointestinal (GI) digestion model was applied and multiple reaction monitoring method for quantification of BCM-7 was set up using Triple-Q LC-ESI-MS specifically f...

A new method of homologation of aldonolactones allowing the incorporation of propionate units with excellent chemo- and stereoselectivity is performed by the magnesium-graphite mediated reaction between Oppolzer sultam derived α-halogenated amides and an aldonolactone.

The scope and limitations of the enzymatic resolution of α,α-disubstituted α-amino acid amides by an amino acid amidase from Mycobacterium neoaurum and of the corresponding ethyl esteis with Pig liver estetase (PLE) have been studied. Moderate enantiomeric excesses were obtained with PLE, wit...

A novel organometallic catalyst (PSNP-CA) has been prepared by post synthesis grafting of COOH functionalized organosilane on porous silica nano particle by using surface hydroxyl groups as anchor point. It was characterized by using an array of sophisticated analytical techniques like 13C CP MA...

Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A series of influenza neuraminidase inhibitors with the pyrrolidinobenzoic acid scaffold containing lipophilic side chains at the C3 position have been synthesized and evalua...

A mutant deficient carboxylesterase which hydrolyzes isoamyl acetate (est2) was isolated from a yeast, Saccharomyces cerevisiae. The EST2 gene was cloned and its nucleotide sequence determined. The EST2 gene has an open reading frame of 714 bp (238 amino acids), and the molecular weight of the g...

The narrow therapeutic range and limited pharmacokinetics of available Antiepileptic drugs (AEDs) have raised serious concerns in the proper management of epilepsy. To overcome this, the present study attempts to identify a candidate molecule targeting voltage gated potassium channels anticipate...

In vacuo molecular dynamics simulation using the CHARMm program was carried out on a putative structure (“state III”) of the repeating pentapeptide, (VPGVG), of elastin at two different extensions. “State III” is the proposed structure for the experimental state III which develops after prol...

Several tripeptide amides of 4-methoxy-2-naphthylamide were synthesized and tested as possible substrates for human plasmin. These peptides contained arginine or lysine as the carboxyl terminus. One such amide, benzyloxycarbonyl-Ala-Ala-Lys-4-methoxy-2-naphthylamine (CBZ-Ala-Ala-Lys-MNA), was fo...

We have previously demonstrated that the intrathecal (i.t.) administration of angiotensin (Ang) II into mice produces a nociceptive behaviour consisting of scratching, biting and licking accompanied by the phosphorylation of p38 MAPK in the spinal cord, which was mediated through AT1 receptors. ...

The synthesis and incorporation of a versatile photochromic dithienylethene-containing diimine ligand, 2-(2′-pyridyl)imidazole, into platinum(II) bis-alkynyl system have been described. All the platinum(II) complexes have been successfully characterized by 1H NMR spectroscopy, ESI mass spectrom...

Lanthanide complexes of the form Ln(tdh)3dpp (where Ln = Nd(III), Eu(III) or Tb(III); tdh = 1,1,1-trifluoro-5,5-dimethyl-2,4-hexanedione and dpp = 2,3-bis(2-pyridyl)pyrazine) have been structurally characterized. X-ray quality crystals were grown by the slow evaporation of concentrated solutions...

Synthesis and characterization of 5,5′-dibromo-2,2′-dipyridyl disulfide and some of its derivatives under mild reaction conditions is described. A series of some novel synthetically important symmetrical/unsymmetrical bromo substituted pyridyl alkyl/aryl sulfur compounds have been easily synth...

The present work reports an efficient one-pot synthesis of symmetrical pyridyl monoselenides by the reaction of bromo-/iodopyridines with the isopropylmagnesium chloride, iPrMgCl followed by quenching with selenyl chloride, SeCl2. The current methodology constitutes a convenient synthesis of bis...

Three new mixed-ligand metal-organic frameworks based on 5,5′-(butane-1,4- diyl)-bis(oxy)-diisophthalic acid and transitional metal cations with the help of two ancillary bridging N-donor pyridyl and imidazole linkers, [Zn(L)0.5(4,4′-bpy)]·2(H2O) (1), [M(L)0.5(bib)]·4(H2O) (M = Zn (2), Co (3...

New monometallic bis-bipyridyl Ru(II) and Os(II) complexes bonded with high nitrogen content five membered aromatic dianionic ligands 5,5′-bis-tetrazolate (bt) and N,N-bis(tetrazol-5-yl)-amine (bta) have been prepared. NMR results presented are consistent with N1-N1 bidentate chelate bonding to...