Treatment of [Os3(CO)10(NCMe)2] (1) with 1-(2-thiazolylazo)-2-naphthol resulted in two new clusters [(μ-H)Os3(CO)10{NC3HSNNC10H6(OH)}] (2) and [(μ-H)Os3(CO)9(μ-η3-NC3H2S(NN)C10H6(O)] (3) in 30 and 45% yields, respectively. Cluster 2 contains an azo ligand moiety in the usual orthomet...

A new rhodamine functionalized Schiff base (3′,6′-bis(diethylamino)-2-((Z)-(5-((E)-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)diazenyl)-2,4-dihydroxybenzylidene) amino)spiro[isoindoline-1,9′-xanthen]-3-one (1) has been synthesized and was characterized spectroscopically. The opt...

Some 4-chloro, 3,5-dimethylisoxazole copper(II) complexes have been prepared and characterized by the infrared, electronic, paramagnetic resonance spectroscopy and molar conductivity values.The ligand acts as monodentate N-bonded, the halide complexes are tetrahedral, while the perchlorate deriv...

GPR40 is an attractive target due to its glucose-stimulated insulin secretion effect with low risk of causing hypoglycemia, which also can be seen from the clinical studies using TAK-875 (fasiglifam). In the present studies, we discovered a series of analogues containing 3,5-dimethylisoxazole as...

The bromodomain and extra-terminal (BET) family of proteins, consisting of the bromodomains containing protein 2 (BRD2), BRD3, BRD4, and the testis-specific BRDT, are key epigenetic regulators of gene transcription and has emerged as an attractive target for anticancer therapy. Herein, we descri...

The mutagenicity of the DNA base O-alkylation adduct, O4-ethylthymine, specifically incorporated into the plasmid vector pUC8 at the unique SalI and HincII recognition sites, was studied in vivo. Escherichia coli, Micrococcus luteus and AMV DNA polymerases catalyze the incorporation of O4-ethylT...

Chirally modified γ-Al2O3 containing different amounts of cinchonidine were prepared by the chemical modification of cinchonidine with trimethoxysilane (TMS-CD). These solids were used as support of Pt catalysts containing 1 wt% Pt by chemical reduction of the hexachloroplatinic acid with H2 at...

Publisher SummaryThis chapter discusses properties and synthesis of certain fluorine-containing carboxylic acids. Abridged survey of organic chemical mechanisms related both to chemical behavior of fluoro carboxylic acids and to their syntheses is included in this chapter. The fate of the C-F bo...

The comprehension of solid-liquid equilibria involved in the quaternary system NaBH4–NaBO2–NaOH–H2O allows us to follow the evolution of mixtures during the sodium borohydride hydrolysis reaction for hydrogen generation. The addition of sodium hydroxide on saturated solutions of sodium borohy...

To assist in the practical implementation of irreversible (reactive) hydrogen storage for automotive applications, the separation of the reactants and products is beneficial. This separation could be effective on board where the build-up of reaction products might prove detrimental to operation,...

Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing ada...

A novel [4 + 1] cycloaddition protocol for the synthesis of dihydrobenzo(naphtho)furan skeletons from readily available 2-(2-nitrovinyl)-phen(naphth)ols and malonate esters via a tandem Michael addition/iodine-catalyzed oxidative annulation has been developed. This method provides a new and faci...

A new fluorescent enhanced probe based on (E)-9-(2-nitrovinyl)-anthracene is developed, which shows high selectivity and sensitivity for the detection of bisulfite anions at Na2HPO4 citric acid buffer solutions (pH 5.0). When addition of HSO3−, the fluorescence intensity is significantly enhance...

The six-coordinate heme Fe(II)-NO/2-nitrovinyl species in myoglobin has been detected and characterized by resonance Raman spectroscopy. The Fe(II)-14NO and 15N-O stretching frequencies of the ferrous heme nitrosyl/2-nitrovinyl species are detected at 560 and 1587 cm−1, frequencies that are simi...

The involvement of reactive oxygen species and oxidative stress in 2-(2-nitrovinyl) furan mediated bacterial cell death was investigated in Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Time kill assay resulted in significant decrease in the optical density and colony-formi...

The influence of 2-(2-nitrovinyl) furan on the activities of selected bacteriostatic and bactericidal antibiotics was investigated. Minimum inhibitory concentration and fractional inhibitory concentration index were determined to evaluate the interaction between 2-(2-nitrovinyl) furan and the an...

2-(2-nitrovinyl) furan is a broad-spectrum antibacterial agent with activity against Gram-positive and Gram-negative bacteria. In this study, the contributions of reactive oxygen species, oxidative DNA damage and glutathione depletion to its activity against Acinetobacter baumannii was investiga...

TRPA1 channels have been found to play an important role in mammalian pain sensation, especially when the pain is caused by chemicals on site of inflammation. A large number of structurally diverse chemicals are found to activate TRPA1 channels, implicating a potential chemosensor in neuronal no...

SummaryItch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypeptide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching responses in mice, but it is unclear which itch-in...

Signal-response coupling was studied in an exocrine female accessory sex gland (albumen gland) of the freshwater snail Lymnaea stagnalis. Glands were incubated in vitro with Calfluxin (CaFl), a neuropeptide which stimulates the influx of Ca2+ into the mitochondria of the secretory cells. This in...