(3Z,6Z,9Z)-Dodecatrienoic acid, proposed as a possible precursor of algal sex attractants, has been identified from female gametes of Analipus japonicus by comparison of HPLC analyses and mass spectral data with those of a synthetic sample.

We developed a curcumin-based chemosensor (DCD) for selective and efficient detection of Picric acid (PA). The developed chemosensor DCD exhibit a broad emission band at 516 nm and shows green colour fluorescence in DMSO/H2O solution (8:2, v/v) due to the more conjugations of its double bonds. U...

In this study, the immunogenicity and protective capacity of a new recombinant vaccine candidate, the rFh14-3-3z protein was analysed in sheep experimentally challenged with Fasciola hepatica, in terms of fluke burden, faecal egg counts, hepatic damage and humoral immune response. Three groups o...

We studied the effects of the alkyllysophopholipid 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine (ET-18-OCH3) on membrane associated protein kinase C (PK-C) activity in ET-18-OCH3 sensitive HL-60 cells and in two resistant cell types, Me2SO differentiated HL-60 cells and K562 cells. HL-60 ...

The influence of cholesterol (CHO) on the phase behavior of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) planar supported lipid bilayers (PSLBs) was investigated by sum-frequency vibrational spectroscopy (SFVS). The intrinsic symmetry constraints of SFVS were exploited to measure the asymme...

Crystallization kinetics of binary mixture phases of SOS (1,3-distearoyl-2-oleoyl-sn-glycerol) and SSO (1,2-distearoyl-3-oleoyl-rac-glycerol) were examined with time-resolved X-ray diffraction (XRD) and DSC methods. Formation of three polymorphic forms, named αc, β′c and βc, of a molecular c...

Interactions between hyaluronan and the cationic surfactant Septonex were studied using high resolution ultrasound spectroscopy. Four different interaction regions were identified in aqueous solution in a narrow interval of surfactant concentrations. In contrast, in 0.15 mol/L NaCl solution, ess...

A simple, efficient catalytic asymmetric Michael addition of malonates to unsaturated ketones has been successfully developed. This process was promoted by rare earth metal complexes 1–4 bearing a chiral phenoxy functionalized prolinol ligand at room temperature [L1RE(L1H) (H2L1 = (S)-2,4-di-te...

The thermal decomposition of 2-(4-nitrophenyl)- and 2-(2,4-dinitrophenyl)malonic acids, the corresponding diethyl esters, and the respective sodium carboxylates has been examined using thermogravimetry. Thermal decomposition of the carboxylic acids occurs by sequential loss of two moles of carbo...

The condensation product of Meldrum's acid and 4-nitrobenzaldehyde reacts smoothly with alkyl isocyanides in the presence of alcohols to produce dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates in excellent yield. This reaction provides a useful synthetic route to highly funct...

A monoaza-15-crown-5 lariat ether derived from d-glucose 1 has been applied as a chiral phase-transfer catalyst in the Michael addition of diethyl, dimethyl, diisopropyl and dibenzyl malonates to enones under mild conditions to afford the adducts with good to excellent enantioselectivities. In t...

A new Michael-initiated cyclopropanation reaction using α-bromochalcones as Michael acceptor was developed. Compared to previous works using arylidenemalonates as Michael acceptor, this novel protocol could improve the synthesis of trans-isomers of diethyl 2-benzoyl-3-phenyl-cyclopropane-1,1-di...

The potential of photoisomerization of β-(2-furanyl)- and β-(2-thienyl)enones in the field of optical memory was explored by synthesis and thorough studies of the cyclopentene-based series with different substituents on the aryl moiety. X-ray crystallographic analysis of the synthesized β-(2-...

Peripheral-selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-s...

Background: Measurement of cholinesterase activity in serum is important to identify substantial liver disease and damage by pesticides, and to assess the degree of development of fatty liver and preoperative risk. Many procedures using various artificial substrates have been developed but suffe...

A colorimetric method to assay cell proliferation of microorganisms in 96-well microtiter plates using water-soluble tetrazolium salts and electron mediators was developed. Combinations of 6 kinds of water-soluble tetrazolium salts and 27 kinds of electron mediators that considered the metabolic...

We have previously reported that sulfated cyclodextrins inhibit the invasion of Plasmodium merozoites by interacting with receptors present on the surface of erythrocytes. The observation that tetrazolium salts formed stable complexes with the inhibitory sulfated cyclodextrins suggested that tet...

Two 5-nitroisophthalate silver(I) coordination polymers with 2-aminopyrimidyl derivatives, namely [Ag2(apym)1.5(nipa)·H2O]n (1) and [Ag2(dmapym)2(nipa)]n (2) were synthesized and characterized by single-crystal X-ray analysis (apym = 2-aminopyrimidine, dmapym = 2-amino-4,6-dimethylprimidine, H2...

A nephelometric method for the determination of microgram quantities of gold with di-2-thienylketoxime is described. The yellow gold complex, which has the empirical formula Au(C9H6NOS2)2OH, forms a stable suspension when gelatin is added as protective colloid. Many foreign ions do not interfere...

Publisher SummaryThis chapter discusses the preparation of pyrroles from ketoximes and acetylenes. The chemistry of pyrroles also includes complex pyrrole systems, porphirin, and phthalocyanine structures such as haemin, chlorophill, hemoglobin, bile pigments, cytochromes, and vitamin B12. Ketox...