Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several secondary and tertiary fractions. Dinitropyrenes and...

3-Nitrobenzanthrone (3-NBA) is an extremely potent mutagen and suspect human carcinogen found in diesel exhaust. Its isomer 2-nitrobenzanthrone (2-NBA) has also been found in ambient air. These isomers differ in mutagenicity in Salmonella by 2–3 orders of magnitude. To identify their urinary me...

3-Nitrobenzanthrone (3-NBA) is a highly mutagenic compound and possible human carcinogen found in diesel exhaust. 3-NBA forms bulky DNA adducts following metabolic activation and induces predominantly G:C > T:A transversions in a variety of experimental systems. Here we investigated the influenc...

The occurrence of the carcinogenic and extremely mutagenic compound, 3-nitrobenzanthrone, in extracts of ambient particulate matter has been investigated at a semi-rural sampling location. A total of seventeen 24-h samples and fourteen 12-h samples were analyzed for their content of 3-nitrobenza...

3-Nitrobenzanthrone (3-NBA), a potential human carcinogen, is present in diesel exhaust. The main metabolite of 3-NBA, 3-aminobenzanthrone, was detected in urine of miners occupationally exposed to diesel emissions. Environmental and occupational factors play an important role in development of ...

A series of new pyrylium salts that bear sulfonate and phosphonate groups were obtained from the reactions between 2,6-diphenyl-4H-pyran-4-one, sulfonic anhydride, and chlorophosphates, and analyzed spectroscopically. Furthermore, treatment of 2,6-diphenyl-4H-pyran-4-one with phosphoryl chloride...

A group of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2-hydroxycyclohexyl)acetamides (1–7) and -ethylamines (8–9) have been synthesized and investigated for their anticonvulsant activity. One of them, racemic trans-2-(2,6-dimethylphenoxy)-N-(2-hydroxycyclohexyl)acetamide proved to be the most e...

The 1-decalone anodic oxidation products in alkaline hydroalcoholic medium with platinum anode are identified. The 5-cyclopentyl-5-hydroxypentanoic acid lactone formation evidence a ring contraction process through a carbocationic intermediate.

Recently, more and more concomitant EGFR mutations and ALK rearrangement are observed from the clinic, which still lacks effective single-agent therapy. Starting from ALK inhibitor 14 (TAE684), we have developed a highly potent EGFR/ALK dual kinase inhibitor compound 18 (CHMFL-ALK/EGFR-050), whi...

Methods for the preparation of ammonium-type hexafluorotitanates are described. Solubilities, infra-red spectra and X-ray powder diffraction patterns are reported. Thermal decomposition of some of these materials occurs on sublimation and the products obtained are reported. These decomposition p...

Preparation of well-ordered TiO2 films from alkaline solution by liquid phase deposition (LPD) method is still challenging owing to the fact that, in traditional mixing process, several disadvantages exist in controllable homogenous chemical reactions. In this contribution, mixing process in a p...

Vapor–liquid equilibrium at 94 kPa has been determined for the ternary system ethyl 1,1-dimethylethyl ether (ETBE)+heptane+octane. The system deviates slightly from ideality and no azeotrope is present. The ternary activity coefficients and the boiling points of the system have been correlated ...

ObjectivesThis study genotyped oral isolates of Candida albicans and C. dubliniensis by analyzing 25S rDNA transposable intron and evaluated their virulence attributes in oral candidiasis.

BackgroundThe presence of intron 25S allows to divide the Candida albicans species into three subclasses (A, B, C). Intronless and intron harboring strains were reported to have different susceptibility to some drugs, for example to flucytosine and bleomycin.

The reaction of trimethyl(methylthio)stannane with methyl iodide was reinvestigated. Trimethylsulfonium iodide and iodotrimethylstannane were the products which were isolated. Trialkylhalostannanes and alkyl aryl sulfides were obtained in nearly quantitative yield by the reaction of trialkyl(ary...

Novel compounds with antibacterial properties: pyrazoline derivatives were synthesized by the cyclization of various -1-[2-(alkoxy)phenyl]-3-(furan-2-yl) prop-2-en-1-one 1a–1d with N-substituted phenyl hydrazine in the presence of CH3COOH in ethanol. The structures of these compounds were eluci...

The key function of microtubules and mitotic spindle in cell division make them attractive targets in anticancer therapy. In the present study, functionalized in 3 position 2-phenyl- and 2-alkylbenzo[b]furans were synthesized and evaluated as antitumor agents. Among the synthesized derivatives 1...

The γ-arylation of substituted silyl-activated butenolides has been studied using a broad scope of unsymmetrical hypervalent diaryliodonium salts via a palladium- or copper-catalysed coupling reaction, yielding interesting reactivity trends. The mild catalytic conditions and coupling partner va...

NRH:quinone oxidoreductase 2 enzyme (NQO2) is a potential therapeutic target in cancer and neurodegenerative diseases, with roles in either chemoprevention or chemotherapy. Here we report the design, synthesis and evaluation of non-symmetrical furan-amidines and their analogues as novel selectiv...

A facile synthesis of trisubstituted imidazoles containing furan rings was reported. Imidazoles were produced from 1,2-di(furan-2-yl)-2-oxoethyl carboxylates over solid alumina as solid support impregnated with ammonium acetate under solvent-free microwave-assisted conditions. The method possess...