A CuBr2-catalyzed alkylation of furans with a broad scope of benzyl alcohols and benzaldehydes is reported. Reaction proceeds efficiently under mild reaction conditions requiring no inert atmosphere or other precautions. Moreover, it is shown that CuBr2 catalyzes domino reactions of furans with ...

We have developed an unprecedented base-promoted oxidative coupling of 2-hydroxy-1,4-naphthoquinones with (Z)-2-ylideneimidazo[1,2-a]pyridin-3(2H)-ones, which provide a convenient approach to access novel naphtho[2,3-b]furan-4,9-dione derivatives with a 2-aminopyridine moiety in acceptable yield...

The acid-catalyzed rearrangement of 5-alkyl-2-[2-(sulfonylamino)phenyl]furans into 2-(2-oxoalkyl)indoles is described. When the N-sulfonyl group in the starting compounds was displaced by an N-acyl group, the corresponding indoles were not formed under the same reaction conditions due to the in ...

A series of L-shaped ortho-quinone analogs were designed by analyzing the binding mode with NQO1. Metabolic studies demonstrated that compounds 2m, 2n and 2q exhibited higher metabolic rates than β-lapachone. The docking studies, which supported the rationalization of the metabolic studies, con...

The release of pro-inflammatory mediators, such as prostaglandines (PGs) and leukotrienes (LTs), arising from the arachidonic acid (AA) cascade, play a crucial role in initiating, maintaining, and regulating inflammatory processes. New dual inhibitors of 5-lipoxygenase (5-LO) and microsomal pros...

It is well known that very few women who possess sperm immobilizing antibodies in their sera can conceive naturally even though there are no abnormalities in their reproductive organs on routine medical examination. A monoclonal antibody (MAb), designated 2H12, was produced by immunizing a BALB/...

Keratan sulfate (KS) was N-deacetylated with anhydrous hydrazine and then degraded with nitrous acid, and the products were reduced with NaBT4. Radiolabelled disaccharides constituted at least 76% of the total oligosaccharide fraction. Three major disaccharides were isolated and identified. Of t...

A novel non-aqueous redox flow battery employing tris(1,10-phenanthroline) complexes of iron(II) and cobalt(II) as active species is proposed and investigated for energy storage application. The [Fe(phen)3]2+/3+ and [Co(phen)3]+/2+ (phen = 1,10-phenanthroline) redox couples are used as the posit...

ABSTRACTThe antifungal activity of amphotericin B (AmB) incorporated in three cholesteryl carbonate esters (CCEs), sodium cholesteryl carbonate, cholesteryl palmityl carbonate, and dicholesteryl carbonate, was examined to assess their potential for use in a dry powder aerosol. Formulations conta...

High-resolution calorimetric measurements made near the smectic-cholesteric transition in COC at 1, 1500, and 2625 bar do not support a reported high-pressure tricritical point but do indicate a monotonic decrease in the transition entropy with pressure.

The influence of the phase state of the liquid crystalline solvents 4-n-octyl-cyanobiphenyl (8CB) and cholesteryl oleyl carbonate (COC) on the flourescence of the intermolecular perylene—N,N-dimethylaniline (DMA) exciplex was studied. The introduction of DMA into perylene solutions in COC or 8C...

An electron beam has been used as an ohmic contact to films of cholesteryl oleyl carbonate (COC). Incremental charging experiments show that the injected electrons propagate some tens of microns before becoming trapped to form stable, negative molecular ions. Although these ions approximately fo...

Cholesteryl oleyl carbonate (COC) was embedded in a cellulose nitrate membrane for the purpose of developing a drug delivery system with a thermal stimulus response. The thermophysical properties of COC were determined by thermal analysis and microscopic Fourier transform infrared spectroscopy w...

The crystal structure as well as the microstructure, i.e., size and strain, of crystallites of cholesteryl oleyl carbonate was determined from X-ray powder diffraction data. The X-ray line broadening was analyzed through the refinement of TCH-pseudo-Voigt function parameters (isotropic effects) ...

3,4,5,6-Tetra-O-benzoyl-d-glucose diethyl dithioacetal (2) reacts with ethanethiol under acidic conditions to afford 3,4,5,6-tetra-O-benzoyl-2-S-ethyl-2-thio-d-mannose (3), the stereochemistry at C-2 of which has been assigned by chemical conversions on its debenzoylated derivative, the crystall...

With the advantages of excellent optical properties and biocompatibility, single-strand DNA-functionalized quantum dots have been widely applied in biosensing and bioimaging. A new aptasensor with easy operation, high sensitivity, and high selectivity was developed by immobilizing the aptamer on...

Edifenphos (EDF), an important organophosphate fungicide used in agriculture, is a great threat to human health and environment. To assess the toxicity of EDF at the level of protein molecule, the effect of EDF on human serum albumin (HSA) was investigated by biophysical and biochemical approach...

The sensitive detection of iprobenfos (IBF) and edifenphos (EDI) was successfully conducted by using a new aptamer-based colorimetric multi-aptasensor. The dissociation constants of this multi-target aptamer to both iprobenfos and edifenphos were found to be 1.67 μM and 38 nM, respectively, acc...

Edifenphos (EDF) (O-ethyl-S, S-diphenyldithiophosphate) is an organophosphate pesticide that is extensively used as a fungicide in agricultural rice fields. However, EDF accumulated in various agricultural products and caused potential health hazards to human and other living organisms. Therefor...

Edifenphos is an important organophosphate pesticide with many antifungal and anti-insecticidal properties but it may cause potential hazards to human health. In this work, we have tried to explore the binding mode of action and mechanism of edifenphos to calf thymus DNA (CT-DNA). Several experi...