The characteristic effects of sulfatide and its derivatives on the stability of small unilamellar vesicles of egg phosphatidylcholine liposomes in phosphate-buffered saline were investigated by measuring the leakage of carboxyfluorescein that had been entrapped in these vesicles. We found that b...

Scavenger receptors have been proven to be implicated in the formation of atherosclerotic lesions. A series of novel derivatives of sulfatides were synthesized, and their inhibitory activities against incorporation of DiI-acetyl-LDL into macrophages were evaluated in order to clarify the structu...

Sulfatides – sulfated derivatives of galactocerebroside – are endogenous ligands for P- and L-selectins and are able to induce intracellular signaling in neutrophils through a L-selectin dependent pathway. Sulfatides are implicated in a variety of physiological functions and have been found to...

Experimental studies have shown that intrapulmonary leukocyte sequestration and activation is implicated in the pathogenesis of acute lung injury during endotoxemia. Selectins are involved in the adhesion of leukocyte to the endothelium. Sulfatide is recognized by P selectin and blocks this adhe...

Publisher SummarySulfatide or ceramide galactosyl-3’-sulfate is a major sulfoglycolipid of the mammalian nervous system, kidney, and spleen and is present in low concentrations in other tissues. In the nervous system, sulfatide is an integral constituent of myelin membranes and is biosynthesize...

Cobra CTX A3, the major cardiotoxin (CTX) from Naja atra, is a cytotoxic, basic β-sheet polypeptide that is known to induce a transient membrane leakage of cardiomyocytes through a sulfatide-dependent CTX membrane pore formation and internalization mechanism. The molecular specificity of CTX A3...

The chemistry of N,N′-bisazaheterocycles is gaining importance recently because of their potential role in (1) widening the available pool of chiral auxiliaries in asymmetric synthesis; (2) discovering new molecules as drug candidates; (3) developing organic polymers for use in light harvesting...

A number of potent 2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine CCR4 antagonists binding to the extracellular allosteric site were synthesised. (R)-N-(2,4-Dichlorobenzyl)-2-(2-(pyrrolidin-2-ylmethyl)-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine (R)-(18a) has high affinity in both the [125I...

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MTT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Co...

Reaction of glycidyl bromides and tosylates with the sodium salt of mercaptopyridine N-oxide led to the formation of episulphides.

Treatment of 4-fluoro-5-(1,1,2,2-tetrafluoroethyl)-3H-1,2-dithiole-3-thione with 2 equivalents of sodium sulfide gives after acidification 3,4-difluoro-2-mercapto-1,6,6aλ4-trithiapentalene, which can be further reduced by sodium sulfide to 3,5-difluoro-4-mercapto-thiopyran-2-thione.

Thirteen unknown impurities in flomoxef sodium were separated and characterized by liquid chromatography coupled with high resolution ion trap/time-of-flight mass spectrometry (LC-IT-TOF MS)with positive and negative modes of electrospray ionization method for further improvement of official mon...

Development of smart regenerative surface is a highly challenging but important task for many scientific and industrial applications. Specifically, very limited research efforts were made for surface regeneration between bio-adhesion and antifouling properties, because bioadhesion and antifoulin...

Two new triorganotin(IV) complexes of Schiff base, Bu3SnL (1) and Ph3SnL (2) (where, L is the monoanion of Schiff base (HL= (E)-4-amino-3-(2-(2-hydroxybenzylidene) hydrazinyl)-1H-1,2,4-triazole-5(4H)-thione)) have been synthesized and thoroughly characterized by elemental analysis, IR, NMR (1H, ...

We describe the synthesis of a novel copper nanoclusters (AMTD-Ac-CuNCs) stabilized by 2-amino-5-mercapto-1,3,4-thiadiazol (AMTD) and acetate (Ac-) simultaneously. The effect of carboxylate on the luminescence of CuNCs was discussed. The as-synthesized CuNCs can be used as a highly sensitive flu...

A fluorescent optode membrane for sodium ion that works on the basis of a cation-exchange mechanism has been developed. The plasticized poly(vinyl chloride) (PVC) membrane incorporating sodium-selective ionophore (4-tert-butylcalix[4]arene tetraacetic acid tetraethyl ester), acidic fluorescent p...

Syntheses are reported of 4-substituted, 4-deoxy analogs of methyl β-D-galactopyranoside (the 4-amino-4-deoxy, 4-azido-4-deoxy, 4-bromo-4-deoxy, 4-chloro-4-deoxy, 4-deoxy-4-fluoro, 4-deoxy-4-iodo, and 4-thio derivatives) as potential substrates of D-galactose oxidase. These syntheses involved n...

This study investigates the dissipation and residue of a metalaxyl and dimethomorph mixed formulation in grape and soil. A high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analytical method was developed to determine the residue of metalaxyl and dimethomorph in grape ...

Dimethomorph (DMM) is a widely used fungicide that shows low toxicity for birds and mammals but can be quite toxic to aquatic organisms. The persistence of DMM in surface waters is thus of high importance, and this work modelled its water half-life time due to photochemical processes. Depending ...

Ten molecularly imprinted polymers coded as MIP1–MIP10 were prepared by the radical bulk polymerization using (R,S)-(±)-2-amino-1-phenylethanol as the structural analog of the target analyte (R,S)-octopamine. The functional monomers, 4-vinylbenzoic acid (1), methacrylic acid (2), acrylic acid ...