A domino reaction for the synthesis of 2-amino-4H-chromene derivatives using bovine serum albumin (BSA) as a catalyst in ethanol was described. The domino Michael addition/intramolecular cyclization reactions of readily available 2-hydroxychalcones with malononitrile gave the desired products in...

In this work we have investigated in details the spectroscopic and reactive properties of newly synthesized imidazole derivative, namely the 1-hydroxy-2-(4-hydroxyphenyl)-4,5-dimethyl-imidazole 3-oxide (HHPDI). FT-IR and NMR spectra were measured and compared with theoretically obtained data pro...

4-Amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones 2a–c and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-ones 3a–f were synthesized from 4-methoxy- and 4-hydroxy-3-nitrocoumarins, and tested for analgesic activity upon oral administration to mice. Most of the compounds prepared exhibited ...

N-Formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) that play critical roles in inflammatory reactions, and FPR-specific interactions can possibly be used to facilitate the resolution of pathological inflammatory reactions. We here report the synthesis and biological evalua...

4-Hydroxyphenylacetic acid-3-hydroxylase from Pseudomonas putida U was purified to homogeneity (96-fold) from bacterial cultures grown in a chemically defined medium containing 4-hydroxyphenylacetic acid as the sole carbon source. The maximal rate of catalysis occurred at pH 7.5 and 40°C. Under...

Noncovalent molecular interactions between helquats, a new class of dicationic helical extended diquats, and several chiral acidic aromatic drugs and catalysts have been investigated using partial-filling affinity capillary electrophoresis (PF-ACE). Helquats dissolved at 1 mM concentration in th...

A concise, metal-free protocol has been established for the preparation of 2-arylbenzoxazoles from 2-nitrophenols and arylacetic acids via a sulfur-mediated redox decarboxylative cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is suitable.

Heterocyclic molecules belong to the most attractive group owing to their broad spectrum of antimicrobial activities. In the undertaken research, a number of new 5-substituted-2-((6-chloro-3,4-methylenedioxyphenyl)methylthio)-1,3,4-Oxadiazole derivatives (6a–l) were synthesized by converting va...

Three tridentate mono-anionic Schiff base ligands of the O,N,S-donor set, namely 3,5-dibromo-N-(2-(methylsulfanyl)phenyl)salicylaldimine (HL1), 5-chloro-N-(2-(methyl-sulfanyl)phenyl)salicylaldimine (HL2), and 3,5-di-tert-butyl-N-(2-(methylsulfanyl)phenyl)-salicylaldimine (HL3) were prepared. Rea...

Isobaric vapor–liquid equilibria for the binary systems tert-butyl alcohol + water, and tert-butyl alcohol + 1-ethyl-3-methylimidazolium dicyanamide ([emim][DCA]), as well as the vapor–liquid equilibria for the tert-butyl alcohol + water + [emim][DCA] ternary system, have been obtained at 100 ...

Solution-processable hole transporting materials (HTMs) play a vital role in organic light emitting diodes (OLEDs) with the purpose of reducing costs and improving productivity. Herein, two twisted HTMs N2,N2,N7,N7-tetrakis(4-(3,6-di-tert-butyl-9H- carbazol-9-yl)phenyl)-9,9-dimethyl-9H-fluoren-2...

Osteosarcoma is the most common bone malignancy and miR-95-3p plays an important role in multiple cancers. The purpose of this study was to explore the effect and potential mechanism of miR-95-3p on the growth of osteosarcoma. In vitro, the osteosarcoma cell lines, SAOS-2 and U2OS cells, were tr...

A new organic nonlinear optical material (4-methylphenyl) (4-methylpiperidin-1-yl) methanone(MPMPM) was synthesized by slow evaporation method using Schotten-Boumann condensation reaction. A single crystal XRD study shows that the compound crystallizes in orthorhombic crystal system with a space...

A chalcogen bond (ChB) is a σ-hole-based noncovalent interaction between a Lewis base and an electrophilic element of Group VI (O, S, Se, Te), which behaves as a Lewis acid. Recently, we demonstrated that halogen bond, the more familiar σ-hole-based interaction, is able to promote the enantios...

Starting from the high-performance liquid chromatography (HPLC) enantioseparation data collected by using twelve polyhalogenated 2,2′-dichloro-3-substituted-5,5′-dihalo-4,4′-bipyridines as test probes on seven polysaccharide-based chiral stationary phases (CSPs) under multimodal elution, the ...

Ruthenium μ-oxo dimers with chloro-substituted 2,2′-bipyridines [L2(H2O)RuIIIORuIII(OH2)L2]4+ (L= 4,4′-dichloro- or 5,5′-dichloro-2,2′-bipyridine) were synthesized. Electrochemical studies on the complexes showed that the RuIII|O|RuIII dimer undergoes a reversible one-electron oxidation to ...

A Cs2CO3-catalyzed alkylation reaction of indoles with trifluoromethyl ketones was presented. Both alicyclic and aromatic trifluoromethyl ketones as well as various substituted indoles are compatible with the methodology. Good to excellent yields of the corresponding trifluoromethyl substituted ...

The synthesis of (2RS)-1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol ((RS)-9) and its enantiomers has been described and tested for electrocardiographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors' binding af...

In the pharmaceutical industry where the supercritical fluid-based technologies are utilized it is very important and vital to know the accurate value of the equilibrium solubility of solids required for the engineers to determine the size of the equipments. According to this requirement, the pu...

O-(5-Acetamido-3,5-dideoxy-d-glycero-α-d-galacto-2-nonulopyranosylonic acid)-(2→6)-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-(1→3)-l-serine, a structural unit occurring in various submaxillary mucins, was synthesized for the first time by using O-[methyl (5-acetamido-4,7,8,9-tetra-O-acety...