Deprotonation of diethyl (2-carboethoxy)benzylphosphonate using sodium ethoxide followed by reaction of the carbanion with furfural or aryl aldehydes gives diethyl (E)-1-(2′-carboxyphenyl)-1-phosphono-2-arylethenes that are formed via intramolecular Stobbe-like condensation reactions.

Spectroscopic properties of Ln(III) complexes with diethyl benzylphosphonate (PhCH2P(O)(EtO)2) and diethyl (carboxymethyl)phosphonate ((EtO)2P(O)CH2COOH) were investigated using absorption and luminescence spectroscopy. Absorption spectra of organophosphorus ligand with Nd(III) were measured in ...

Spectroscopic properties of UO22+ complexes with diethyl benzylphosphonate (C6H5CH2P(O)(OCH2CH3)2) (L1) and diethyl (carboxymethyl)phosphonate ((CH3CH2O)2P(O)CH2COOH) (L2) were investigated using absorption and luminescence spectroscopy. Studied compounds were characterized using CHN microanalyt...

Correlation between Fe content and z value on the structural and magnetic properties of the Sm(CobalFexCu0.06Zr0.025)z magnets (x = 0.20, 0.25, 0.28, and z = 7, 9.5) has been investigated. It is found that the cellular phases in the magnets grow up with increasing Fe content, so the cell boundar...

The software z-Tree is used for thousands of economic experiments worldwide. z-Tree stores experimental data in a way that minimizes the risk of losing data. However, it may be cumbersome to manually read this data into a statistical package. The purpose of the R-package zTree is to make the pro...

Overexpression of P-glycoprotein (P-gp) is one of the major obstacles to successful cancer chemotherapy. In this study, we examined the ability of 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide (C-4) to reverse multidrug resistance (MDR) in P-gp expressing KBV20C cells...

The conformational behavior and structural stability of trans-1,2-bis(3,5-dimethoxy phenyl)-ethene (TDBE) were investigated by using density functional theory (DFT) method with the B3LYP/6-311++G(d,p) basis set combination. The vibrational wavenumbers of TDBE were computed at DFT level and compl...

A novel series of Schiff bases based on of 4-amino-5-(3,5-dimethoxy-phenyl)-4H-1,2,4-triazol-3-thiol scaffold was prepared by heating thiocarbohydrazide and 3,5,-dimethoxy benzoic acid at the temperature above its meting point, and subsequently, treating with substituted benzaldehydes. The chemi...

Propylene carbonate (PC) is a non-toxic solvent currently used in various pharmaceutical formulations. Consequently, a simple, cost-effective and most accurate analytical method for the quantification of this optical inert solvent is of major interest. Based on a consecutive three-step reaction ...

Allosteric modulators of G-protein-coupled receptors have lately gained significant traction in drug discovery. Recent studies have shown that allosteric modulation of serotonin 2C receptor (5-HT2C) as a viable strategy for the treatment of various central nervous system (CNS) disorders. Conside...

The treatment of tri(p-tolyl)phosphine with 1,2-bis(bromomethyl)benzene results in (2-bromomethylbenzyl)tri(p-tolyl)phosphonium bromide. The resulted phosphonium salt reacts with palladium acetate(II) in a molar ratio of 1.5:1, respectively, to give [(CH3C6H4)3PCH2C6H4CH2OC(O)CH3]2[Pd2Br6], bis[...

In the current communication, we report the synthesis, spectroscopic, crystal structure, DFT and photophysical studies of a new nicotinonitrile derivative, viz. 2-methoxy-6-(4-methoxy-phenyl)-4-p-tolyl-nicotinonitrile (2) as a potential blue light emitting material. The compound 2 was synthesize...

1-(p-Tolylsulfinyl)-2-(chloromercurio)ferrocene (2) was prepared by direct mercuration of ferrocenylsulfoxide (1). This reaction can be performed at room temperature in open air. Cross-coupling reactions of compound 2 and aryl halides especially aryl iodides resulted in 1,2-disubstituted ferroce...

This work reports on the preparation of the complexes [PdCl2(Y1)2], [PdCl2(Y2)2] (Y1 = (p-tolyl)3PCHCOCH3 (1a); Y2 = Ph3PCHCO2CH2Ph (1b)), [Pd{CHP(C7H6)(p-tolyl)2COCH3}(μ-Cl)]2 (2a), [Pd{CHP(C6H4)Ph2CO2CH2Ph}(μ-Cl)]2 (2b), [Pd{CH{P(C7H6)(p-tolyl)2}COCH3}Cl(L)] (L = PPh3 (3a), P(p-tolyl)3 (4a))...

Two cyclometalated alkynylgold(III) complexes [AuCl(tpy)(C≡C–C6H4CH3)] (1) and [AuCl(ppy)(C≡C–C6H4CH3)] (2), where ppy = 2-phenylpyridine and tpy = 2-(p-tolyl)-pyridine, were successfully synthetized. Their photophysical properties were investigated by absorption and photoluminescence spectr...

Reaction of [Ru(Cp∗)(CH3CN)3](PF6) with P(o-tolyl)3 affords [Ru(Cp∗){(η6-o-tolyl)P(o-tolyl)2}](PF6) (4) in which the P-atom is not coordinated to the metal. The solid-state structure of 4 has been determined. A related reaction with P(p-tolyl)3 reveals a small quantity [Ru(Cp∗){(η6-p-tolyl)P(o...

3-Nitro-2-trichloro(trifluoro)methyl-2H-chromenes undergo a formal [4+2] cycloaddition reaction to cyclohexanone and pinacolone enamines, producing chromeno[3,4-c][1,2]benzoxazin-6-oxides with high diastereoselectivity and in good yields. In addition, some novel 2,3,4-trisubstituted chromanes we...

The drug research and development nowadays is focusing on multi-target drugs. In the treatment of cancer, therapies using drugs inhibiting one numerous targets signify a novel viewpoint. In comparison with traditional therapy, multi-targeted drugs directly aim cell subpopulations which are invol...

A series of new α,β-unsaturated carbonyl-based cyclohexanone derivatives was synthesized by simple condensation method and all compounds were characterized by using various spectroscopic techniques. New compounds were evaluated for their effects on acetylcholinesterase (AChE) and butyrylcholin...

Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of aryl sulfonamides with cyclohexanones. Various N-aryl sulfonamides were selectively obtained in good yields using molecular oxygen as oxidant. The reaction tolerated a wide range of functi...