A range of α-alkoxyphosphine oxides, including novel α-methoxyallyl oxides, are readily prepared from chlorodiphenylphosphine and acetals.

A catalytic amount of chlorodiphenylphosphine induced the polymerization of α,β-unsaturated esters. The polymerization was greatly accelerated by addition of a catalytic amount of epoxide.

Functionalized triarylphosphines are obtained with good yields in a one-step reaction of an equimolar mixture of chlorodiphenylphosphine and an aromatic bromide in NMP or DMF at 110°C in the presence of zinc dust and a catalytic amount of NiBr2(bpy). A possible catalytic pathway is discussed.

Condensation of carboxylic acids with alcohols, phenols and thiols proceeded smoothly to afford carboxylic acid alkyl esters, phenolic esters and thioesters by using the combination of chlorodiphenylphosphine, imidazole and molecular iodine in refluxing acetonitrile. Esterification with this mix...

Synthetic cannabinoids, recently used as alternatives to Cannabis sativa, are among the most frequently abused drugs. Identified in 2014, the synthetic cannabinoids N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide (5F-AB-PINACA) and methyl [1-(5-fluoropentyl)-1H-...

Phenylhydroquinone (PHQ), a metabolite of o-phenylphenol (OPP), is easily autoxidized to phenylbenzoquinone (PBQ), via the semiquinone (phenylsemiquinone, PSQ) with concomitant production of superoxide anion radicals (O2•). We have used scavengers of active oxygen species to examine whether or n...

The interaction of o-phenylphenol (OPP) and its metabolites with DNA was examined. As a model system, the reactivities of OPP and its metabolites with DNA were studied by using pUC18 DNA. The major metabolite formed in vitro from OPP by mixed function oxidase was phenylhydroquinone (PHQ). This r...

o-Phenylphenol (OPP) and its sodium salt, sodium o-phenylphenate are broad spectrum fungicides and disinfectants with widespread usage. Both chemicals have been reported to induce cancer in the kidney and urinary bladder of Fischer 344 rats. Recently it has been proposed that the metabolic activ...

Crystalline benzoic acid has been studied by far-infrared spectroscopy in the spectral region of 20–230 cm−1 with a view to a determination and an assignment of the pure lattice and the intermonomer vibrations. An anomalous behaviour, similar to the one found earlier in the mid-IR, is observed ...

We present results on a new, laboratory synthesized ferrocene-derivative, i.e. 4-(ferrocenylmethylimino)-2-hydroxy-benzoic acid. Thin films with controlled thickness are deposited by matrix-assisted pulsed laser evaporation (MAPLE), on quartz and silicon substrates, with the aim of evaluating th...

Fractionation of dichloromethane extracts from the leaves of Piper heterophyllum and P. aduncum afforded three prenylated hydroxybenzoic acids, 3-[(2E,6E,10E)-11-carboxy-3,7,15-trimethyl-2,6,10,14-hexadecatetraenyl)-4,5-dihydroxybenzoic acid, 3-[(2E,6E,10E)-11-carboxy-13-hydroxy-3,7,15-trimethyl...

An LC–MS/MS method for simultaneous determination of hippuric acid (HA) and benzoic acid (BA) in monkey urine after direct injection was developed. Since HA and BA are endogenous compounds in urine, surrogate standards (13C6-hippuric and 13C6-benzoic acid) were employed to generate calibration ...

Metabolism of benzoic acids and benzaldehydes are crucial to produce hormones, defense compounds and attractants for pollinators in plants. Tricholoma matsutake contains benzoic acid and benzaldehyde, but their roles have not been fully studied. First we conducted tracer experiments to gain insi...

A paper spray mass spectrometry (PS-MS) method has been developed for the rapid quantification of benzoic acid (BA) and vitamin C (VC) in beverages. Using BA-d5 as an internal standard (IS) to analyze BA and VC, the calibration curves ranged from 0.3 to 100 μg/mL for BA and 1 to 100 μg/mL for ...

In contrast to the structure of bis(trimethylsilyl) amides, which, except for the formamide, exist in the imidate form and undergo rapid exchange of trimethylsilyl groups, the bis(dimethylsilyl)amides prepared in this study exist in the amide form and undergo rapid rotation around the CN bond....

Propylene oxide (PO) was polymerized by some diphenylzinc-ketone systems. Cocatalytic effects of nine ketones were examined. The systems are greatly influenced by the nature of the ketone and by the molar ratio of ketone to diphenylzinc. Methyl and cyclic ketones were the most effective as cocat...

Acetylation is the major metabolic pathway of isoniazid (INH) mediated by N-acetyltransferases (NATs). Previous reports suggest that slow acetylators have higher risks of INH hepatotoxicity than rapid acetylators, but the detailed mechanisms remain elusive. The current study used Nat1/2(−/−) mic...

o-Tributylstannylmethyl benzaldehyde reacts with Zn in the presence of TMSCl and 2,6 lutidine at room temperature to give α-trimethylsiloxy-o-quinodimethane, which is trapped with dienophiles to afford cycloadducts in good to high yields.

A series of novel 3-quinolinecarboxylic acid derivatives has been prepared and their antibacterial activity evaluated. These derivatives were characterized by a difluoromethoxy group attached to the 6-position and substituted piperazinyl groups attached to the 7-position.

An (S)-ω-transaminase from the thermophilic eubacterium Sphaerobacter thermophilus was expressed and functionally characterized. The enzyme showed good stability at high temperature and in the presence of various substrates. Substrate specificity analysis showed that the enzyme had activity tow...