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Siwei Development Group Ltd.

Product name: Ticargrelor CAS No.:274693-27-5 Molecule Formula:C23H28F2N6O4S Molecule Weight:522.57 Purity: 99.0% Package: 25kg/drum Description: White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Ticargrelor

Cas:274693-27-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

Ticagrelor

Cas:274693-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC Ticagrelor 274693-27-5

Cas:274693-27-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 274693-27-5 Ticagrelor

Cas:274693-27-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Kono Chem Co.,Ltd

Specifications The specification for Argatroban Ticagrelor is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 20

CAS:274693-27-5 Ticagrelor

Cas:274693-27-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Ticagrelor tablets 60mg;90mg

Cas:274693-27-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Ticagrelor Cas 274693-27-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:N/A Package:10g,100g,1kg/foil bag Appli

High quality Ticagrelor Cas 274693-27-5 with favorable price and good service

Cas:274693-27-5

Min.Order:10 Gram

FOB Price: $45.0 / 50.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

ticagrelor

Cas:274693-27-5

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

TICAGRELOR

Cas:274693-27-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Ticagrelor 274693-27-5 Producer

Cas:274693-27-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Ticagrelor

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality TICAGRELOR

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

HANGZHOU CLAKE BIOTECH CO.,LTD

1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Package:25kg/drum Application:active pharmaceutical ingredient

Ticagrelor

Cas:274693-27-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ticagrelor Manufacturer/High quality/Best price/In stock

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ticagrelor

Cas:274693-27-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TICAGRELOR Basic information Product Name: TICAGRELOR Synonyms: TICAGRELOR;(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]py

274693-27-5

Cas:274693-27-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Ticagrelor Powder 99% CAS 274693-27-5

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 274693-27-5 with fast shipping

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ticagrelor CAS NO.274693-27-5

Cas:274693-27-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ticagrelor/ LIDE PHARMA- Factory supply / Best price

Cas:274693-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Ticagrelor CAS274693-27-5

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Item Name Ticagrelor CAS NO 274693-27-5 Function 1. Ticagrelor is used to lower the chance of heart attack, stroke, and death in some people. 2. Ticagrelor is used to lower the c

Ticagrelor

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Ticagrelor(CAS NO.: 274693-27-5),AR-C 126532XX, AZD 6140

Cas:274693-27-5

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou Ocean Chemical Co., Ltd.

The company's r&d and pilot base has advanced and complete synthetic equipment and analytical testing equipment, and the r&d investment takes up 30% of the capital, and develops 3-5 new products every year.We has established close scien

TICAGRELOR

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Bulk Supply Top Quality 99.5% Ticagrelor CAS 274693-27-5 with Reasonable Price

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed

High quality Ticagrelor 99%

Cas:274693-27-5

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Good Quality Pharmaceutical Raw Powder Ticagrelor with 99% purity Ticagrelor raw powder

Cas:274693-27-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: TICAGRELOR Synonyms: 1,2-Cyclopentanediol, 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-;Ticagrelor, >=98%;Ticagrelo;Ticargre

TICAGRELOR

Cas:274693-27-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

TICAGRELOR

Cas:274693-27-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

TICAGRELOR CAS: 274693-27-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

TICAGRELOR CAS: 274693-27-5

Cas:274693-27-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
274693-26-4

[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol at -3 - 20℃; for 3h; Large scale;97.1%
With hydrogenchloride In methanol at 0 - 10℃; for 2h; Temperature; Large scale;95%
With hydrogenchloride In water; ethyl acetate94.1%
N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-3-((3aS,4R,6S,6aR)-2,2-dimethyl-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazol[4,5-d]pyrimidin-7-amine

N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-3-((3aS,4R,6S,6aR)-2,2-dimethyl-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazol[4,5-d]pyrimidin-7-amine

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0 - 20℃; for 4.5h;97%
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h;86%
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 2h;96%
With triethylamine In tetrahydrofuran at 20℃; for 2h;96%
C9H9F2N*ClH

C9H9F2N*ClH

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25 - 35℃; Product distribution / selectivity;95.5%
C30H34F2N6O4S

C30H34F2N6O4S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol under 3000.3 Torr; for 2h;95.2%
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 24h;95%
(4-{7-[2-(3,4-difluorophenyl)cyclopropylamino]-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}-2,3-dihydroxycyclopentyloxy)acetic acid ethyl ester
1402150-10-0

(4-{7-[2-(3,4-difluorophenyl)cyclopropylamino]-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}-2,3-dihydroxycyclopentyloxy)acetic acid ethyl ester

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 20℃; for 3h; Time;93.8%
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 50 - 60℃; for 3h; Large scale;0.5 kg
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine mandelate
1444301-72-7

(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine mandelate

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 20℃; for 20h;93%
With sodium carbonate In acetonitrile at 20℃; for 20h;93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 5 - 20℃; for 5h;80.24%
Stage #1: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanammonium mandelate With N-ethyl-N,N-diisopropylamine; sodium hydroxide In water; ethyl acetate at 15 - 20℃;
Stage #2: 9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine With N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 1h;
67%
C30H40F2N6O4S

C30H40F2N6O4S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h;93%
C33H38F2N6O4S

C33H38F2N6O4S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 55℃; Temperature;92%
C44H46F2N6O4S

C44H46F2N6O4S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With pyridine hydrochloride at 0℃;91%
tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate
1383715-61-4

tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With phosphoric acid In ethanol at 20℃; for 24h; Reagent/catalyst; Solvent;87%
With phosphoric acid In ethanol; water at 20℃; for 24h;87%
Stage #1: tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate With hydrogenchloride; water In methanol; toluene at 25 - 30℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate pH=> 8;
Multi-step reaction with 4 steps
1.1: iodine / acetone / 2 h / 25 - 60 °C
2.1: potassium carbonate / acetone / 20 h / 55 - 60 °C
3.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C
3.2: 25 - 30 °C / pH 10
4.1: formic acid / palladium 10% on activated carbon / 50 °C
View Scheme
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
376608-71-8

trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran at 20 - 30℃; for 3h; Reagent/catalyst; Solvent;87%
With potassium carbonate In acetonitrile at 25 - 30℃;62.19%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25 - 30℃; for 4h;2.29 g
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
1354945-69-9

9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine

(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine mandelate

(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine mandelate

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 20℃; for 4h;86.2%
C31H42F2N6O6S

C31H42F2N6O6S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With trifluoroacetic acid In methanol at 60℃;86%
C24H26F2N6O5S

C24H26F2N6O5S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane at 30℃; Cooling with ice;85.2%
With sodium hydroxide In 1,4-dioxane; water at 20 - 30℃;85.2%
C32H46F2N6O4SSi

C32H46F2N6O4SSi

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 30℃; for 24h;85%
tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)carbamate
1427524-43-3

tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)carbamate

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With phosphoric acid In methanol; water at 20℃; for 24h;84%
C33H44F2N6O6S

C33H44F2N6O6S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 55℃;84%
C38H46F2N6O6S

C38H46F2N6O6S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 50℃;83%
C31H40F2N6O6S

C31H40F2N6O6S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 0.5h; Reagent/catalyst; Solvent;82.5%
With hydrogenchloride In methanol; water at 0 - 20℃; for 2h; Inert atmosphere;78.2%
C30H40F2N6O5S

C30H40F2N6O5S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h;82%
2-(((3aS,4S,6R,6aS)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2-phenyltetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

2-(((3aS,4S,6R,6aS)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2-phenyltetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h;81%
C28H36F2N6O5S

C28H36F2N6O5S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h;78%
(x)C3H7NO*C23H28F2N6O4S

(x)C3H7NO*C23H28F2N6O4S

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
Stage #1: (x)C3H7NO*C23H28F2N6O4S In isopropyl alcohol; acetonitrile at 65 - 70℃;
Stage #2: With pyrographite at 0 - 70℃; for 2h;
77.6%
2-(((3aS,4S,6R,6aS)-2-(3-(benzyloxy)phenyl)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

2-(((3aS,4S,6R,6aS)-2-(3-(benzyloxy)phenyl)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h;77%
2-(((3aS,4S,6R,6aS)-2-cyclohexyl-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

2-(((3aS,4S,6R,6aS)-2-cyclohexyl-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h;76%
2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol
1383715-59-0

2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
Stage #1: 2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol With acetic acid; zinc In dichloromethane at 5 - 10℃; for 2h;
Stage #2: With acetic acid; sodium nitrite In dichloromethane; water at 0 - 3℃; for 2h;
Stage #3: With hydrogenchloride In methanol; water for 4h;
74%
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C
2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C
3.1: hydrogenchloride; water / toluene; methanol / 2 h / 25 - 30 °C
3.2: pH > 8
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C
2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C
3.1: potassium carbonate / acetone / 24 h / 25 - 60 °C
4.1: hydrogenchloride; water / methanol / 5.5 h / 20 - 55 °C
4.2: 25 - 30 °C / pH 10
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C
2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C
3.1: iodine / acetone / 2 h / 25 - 60 °C
4.1: potassium carbonate / acetone / 20 h / 55 - 60 °C
5.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C
5.2: 25 - 30 °C / pH 10
6.1: formic acid / palladium 10% on activated carbon / 50 °C
View Scheme
2-(((3aS,4S,6R,6aS)-2-(4-chlorophenyl)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

2-(((3aS,4S,6R,6aS)-2-(4-chlorophenyl)-6-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)tetrahydro-4H-cyclopenta[d][1,3,2]dioxaborol-4-yl)oxy)ethan-1-ol

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h;71%
N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-N-{3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}-N’,N’-dimethylsulfuric diamide

N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-N-{3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}-N’,N’-dimethylsulfuric diamide

ticagrelor
274693-27-5

ticagrelor

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 6.5h;67%
ticagrelor
274693-27-5

ticagrelor

C23H27F2N7O6S

C23H27F2N7O6S

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water; acetonitrile at 10℃; for 40h; Solvent; Temperature;94.8%
ticagrelor
274693-27-5

ticagrelor

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol fumarate

(1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol fumarate

Conditions
ConditionsYield
In n-heptane; acetone at 0 - 35℃; for 1h; Solvent; Temperature;94.4%
In acetone at 25 - 30℃;65%
ticagrelor
274693-27-5

ticagrelor

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
274693-26-4

[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetone at 20 - 30℃; for 12h; Inert atmosphere;93%
ticagrelor
274693-27-5

ticagrelor

succinic acid
110-15-6

succinic acid

(1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol succinate

(1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol succinate

Conditions
ConditionsYield
In acetone at 25 - 30℃;81%
ticagrelor
274693-27-5

ticagrelor

aspirin
50-78-2

aspirin

C9H8O4*C23H28F2N6O4S

C9H8O4*C23H28F2N6O4S

Conditions
ConditionsYield
In hexane; dichloromethane at 20℃; for 264h; Product distribution / selectivity;78%
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