Product name: Ticargrelor CAS No.:274693-27-5 Molecule Formula:C23H28F2N6O4S Molecule Weight:522.57 Purity: 99.0% Package: 25kg/drum Description: White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:274693-27-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:274693-27-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:274693-27-5
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquirySpecifications The specification for Argatroban Ticagrelor is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 20
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Unique advantages for Ticagrelor Cas 274693-27-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:N/A Package:10g,100g,1kg/foil bag Appli
Cas:274693-27-5
Min.Order:10 Gram
FOB Price: $45.0 / 50.0
Type:Trading Company
inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:274693-27-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiry1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Package:25kg/drum Application:active pharmaceutical ingredient
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
TICAGRELOR Basic information Product Name: TICAGRELOR Synonyms: TICAGRELOR;(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]py
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:274693-27-5
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:274693-27-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryItem Name Ticagrelor CAS NO 274693-27-5 Function 1. Ticagrelor is used to lower the chance of heart attack, stroke, and death in some people. 2. Ticagrelor is used to lower the c
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:274693-27-5
Min.Order:10 Gram
Negotiable
Type:Other
inquiryThe company's r&d and pilot base has advanced and complete synthetic equipment and analytical testing equipment, and the r&d investment takes up 30% of the capital, and develops 3-5 new products every year.We has established close scien
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:274693-27-5
Min.Order:100 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:274693-27-5
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryProduct Name: TICAGRELOR Synonyms: 1,2-Cyclopentanediol, 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-;Ticagrelor, >=98%;Ticagrelo;Ticargre
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:274693-27-5
Min.Order:1 Kilogram
FOB Price: $200.0 / 300.0
Type:Trading Company
inquiryTICAGRELOR CAS: 274693-27-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:274693-27-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at -3 - 20℃; for 3h; Large scale; | 97.1% |
With hydrogenchloride In methanol at 0 - 10℃; for 2h; Temperature; Large scale; | 95% |
With hydrogenchloride In water; ethyl acetate | 94.1% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 0 - 20℃; for 4.5h; | 97% |
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h; | 86% |
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
ticagrelor
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 2h; | 96% |
With triethylamine In tetrahydrofuran at 20℃; for 2h; | 96% |
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
ticagrelor
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25 - 35℃; Product distribution / selectivity; | 95.5% |
ticagrelor
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol under 3000.3 Torr; for 2h; | 95.2% |
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
ticagrelor
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 20℃; for 24h; | 95% |
(4-{7-[2-(3,4-difluorophenyl)cyclopropylamino]-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}-2,3-dihydroxycyclopentyloxy)acetic acid ethyl ester
ticagrelor
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water at 20℃; for 3h; Time; | 93.8% |
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 50 - 60℃; for 3h; Large scale; | 0.5 kg |
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine mandelate
ticagrelor
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile at 20℃; for 20h; | 93% |
With sodium carbonate In acetonitrile at 20℃; for 20h; | 93% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 5 - 20℃; for 5h; | 80.24% |
Stage #1: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanammonium mandelate With N-ethyl-N,N-diisopropylamine; sodium hydroxide In water; ethyl acetate at 15 - 20℃; Stage #2: 9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine With N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 1h; | 67% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h; | 93% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 55℃; Temperature; | 92% |
ticagrelor
Conditions | Yield |
---|---|
With pyridine hydrochloride at 0℃; | 91% |
tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate
ticagrelor
Conditions | Yield |
---|---|
With phosphoric acid In ethanol at 20℃; for 24h; Reagent/catalyst; Solvent; | 87% |
With phosphoric acid In ethanol; water at 20℃; for 24h; | 87% |
Stage #1: tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate With hydrogenchloride; water In methanol; toluene at 25 - 30℃; for 2h; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate pH=> 8; | |
Multi-step reaction with 4 steps 1.1: iodine / acetone / 2 h / 25 - 60 °C 2.1: potassium carbonate / acetone / 20 h / 55 - 60 °C 3.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C 3.2: 25 - 30 °C / pH 10 4.1: formic acid / palladium 10% on activated carbon / 50 °C View Scheme |
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
ticagrelor
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran at 20 - 30℃; for 3h; Reagent/catalyst; Solvent; | 87% |
With potassium carbonate In acetonitrile at 25 - 30℃; | 62.19% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25 - 30℃; for 4h; | 2.29 g |
9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine
ticagrelor
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; water at 20℃; for 4h; | 86.2% |
ticagrelor
Conditions | Yield |
---|---|
With trifluoroacetic acid In methanol at 60℃; | 86% |
ticagrelor
Conditions | Yield |
---|---|
With water; sodium hydroxide In 1,4-dioxane at 30℃; Cooling with ice; | 85.2% |
With sodium hydroxide In 1,4-dioxane; water at 20 - 30℃; | 85.2% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 30℃; for 24h; | 85% |
tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)carbamate
ticagrelor
Conditions | Yield |
---|---|
With phosphoric acid In methanol; water at 20℃; for 24h; | 84% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 55℃; | 84% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 50℃; | 83% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; for 0.5h; Reagent/catalyst; Solvent; | 82.5% |
With hydrogenchloride In methanol; water at 0 - 20℃; for 2h; Inert atmosphere; | 78.2% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h; | 82% |
ticagrelor
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h; | 81% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 15 - 25℃; for 3h; | 78% |
ticagrelor
Conditions | Yield |
---|---|
Stage #1: (x)C3H7NO*C23H28F2N6O4S In isopropyl alcohol; acetonitrile at 65 - 70℃; Stage #2: With pyrographite at 0 - 70℃; for 2h; | 77.6% |
ticagrelor
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h; | 77% |
ticagrelor
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h; | 76% |
2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol
ticagrelor
Conditions | Yield |
---|---|
Stage #1: 2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol With acetic acid; zinc In dichloromethane at 5 - 10℃; for 2h; Stage #2: With acetic acid; sodium nitrite In dichloromethane; water at 0 - 3℃; for 2h; Stage #3: With hydrogenchloride In methanol; water for 4h; | 74% |
Multi-step reaction with 3 steps 1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C 2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C 3.1: hydrogenchloride; water / toluene; methanol / 2 h / 25 - 30 °C 3.2: pH > 8 View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C 2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C 3.1: potassium carbonate / acetone / 24 h / 25 - 60 °C 4.1: hydrogenchloride; water / methanol / 5.5 h / 20 - 55 °C 4.2: 25 - 30 °C / pH 10 View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C 2.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C 3.1: iodine / acetone / 2 h / 25 - 60 °C 4.1: potassium carbonate / acetone / 20 h / 55 - 60 °C 5.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C 5.2: 25 - 30 °C / pH 10 6.1: formic acid / palladium 10% on activated carbon / 50 °C View Scheme |
ticagrelor
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethyl acetate at 20℃; for 1h; | 71% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 6.5h; | 67% |
ticagrelor
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In water; acetonitrile at 10℃; for 40h; Solvent; Temperature; | 94.8% |
ticagrelor
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In n-heptane; acetone at 0 - 35℃; for 1h; Solvent; Temperature; | 94.4% |
In acetone at 25 - 30℃; | 65% |
ticagrelor
2,2-dimethoxy-propane
[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetone at 20 - 30℃; for 12h; Inert atmosphere; | 93% |
ticagrelor
succinic acid
Conditions | Yield |
---|---|
In acetone at 25 - 30℃; | 81% |
Conditions | Yield |
---|---|
In hexane; dichloromethane at 20℃; for 264h; Product distribution / selectivity; | 78% |
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