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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

quetiapine manufacturer with low price

Cas:111974-69-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Quetiapine 111974-69-7 ISO Producer

Cas:111974-69-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day

Quetiapine

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service Quetiapine CAS 111974-69-7 IN Stock 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol 111974-69-7 111974-69-

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 111974-69-7 Quetiapine

Cas:111974-69-7

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 111974-69-7 with best quality

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:white crystalline powder Storage:Store at -20°C Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China

Quetiapine;2-[2-[4-(6a,10a-dihydrobenzo[b][1,4]benzothiazepin-6-yl)-1-piperazinyl]ethoxy]ethanol;

Cas:111974-69-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Quetiapine 111974-69-7

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

antiviral, 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol CAS:111974-69-7

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $47.0 / 52.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Quetiapine CAS:111974-69-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Quetiapine CAS:111974-69-7

Cas:111974-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Quetiapine

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Quetiapine

Cas:111974-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol 111974-69-7

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Quetiapine

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Quetiapine

Cas:111974-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Quetiapine

Cas:111974-69-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

QuetiapineAppearance:white crystalline Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect

Quetiapine

Cas:111974-69-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol

Cas:111974-69-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

TIANFU CHEM 111974-69-7 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Quetiapine

Cas:111974-69-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--111974-69-7---QUETIAPIN

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol

Cas:111974-69-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--111974-69-7---QUETIAPIN

Cas:111974-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--111974-69-7---QUETIAPIN

Cas:111974-69-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Quetiapine

Cas:111974-69-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Quetiapine

Cas:111974-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--111974-69-7---QUETIAPIN

Cas:111974-69-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Appearance :White or almost white powder Conforms Solubility Slightly soluble in water, in anhydrous ethanol and in methanol. …Appearance:White or almost white powder Storage:cool and dry Package:25kg/drum Application:Antipsych

Quetiapine

Cas:111974-69-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

11-chloro-dibenzo[b,f][1,4]thiazepine
13745-86-3

11-chloro-dibenzo[b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
In toluene at 105 - 107℃;99%
In toluene at 110 - 120℃; for 8h; Product distribution / selectivity;98%
In toluene Reflux;92%
11-chloro-dibenzo[b,f][1,4]thiazepine
13745-86-3

11-chloro-dibenzo[b,f][1,4]thiazepine

(2-(piperazin-1-yl)ethoxy)methanol

(2-(piperazin-1-yl)ethoxy)methanol

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; 4-phenyl-N-methylpyridinium iodide; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc In dimethyl sulfoxide at 80℃; for 8h; Reagent/catalyst; Inert atmosphere;99%
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride
753475-15-9

11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium carbonate; sodium iodide; tetrabutylammomium bromide In toluene at 115 - 120℃; for 17h; Heating / reflux;98.2%
With sodium carbonate; sodium iodide; tetrabutylammomium bromide In butan-1-ol at 115 - 120℃; for 17h; Heating / reflux;96.9%
With sodium carbonate; sodium iodide In butan-1-ol at 115 - 120℃; for 17h; Heating / reflux;94.1%
11-{4-[2-(2-tritiloxiethoxy)ethyl]piperazine-1-yl}dibenzo[b,f][1,4]thiazepine

11-{4-[2-(2-tritiloxiethoxy)ethyl]piperazine-1-yl}dibenzo[b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Stage #1: 11-{4-[2-(2-tritiloxiethoxy)ethyl]piperazine-1-yl}dibenzo[b,f][1,4]thiazepine With toluene-4-sulfonic acid In methanol; toluene for 4h; Heating / reflux;
Stage #2: With hydrogenchloride In water; toluene
Stage #3: With sodium hydroxide In water; toluene pH=9.5; Product distribution / selectivity;
95%
2-nitro-2'-[4-[2-(2-hydroxyethoxy)ethyl]-piperazinylcarbonyl]diphenylsulfide
849790-30-3

2-nitro-2'-[4-[2-(2-hydroxyethoxy)ethyl]-piperazinylcarbonyl]diphenylsulfide

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With formic acid; iron at 85 - 90℃;94.5%
11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine
844639-07-2

11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Stage #1: 11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine With potassium hydroxide In methanol at 20 - 25℃; for 3h;
Stage #2: With hydrogenchloride In water
Stage #3: With sodium hydroxide In water pH=10; Product distribution / selectivity;
94%
With sodium hydroxide In ethanol; water at 20℃; for 0.5h;
With sodium hydroxide; water In methanol at 160℃;
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3; N,N-dimethylaniline / 4 h / Heating
2: xylene / Heating
View Scheme
Multi-step reaction with 2 steps
1: pyrophosphoryl chloride; N,N-dimethyl-aniline / toluene / 4.5 h / 110 - 112 °C / Green chemistry
2: toluene / 105 - 107 °C
View Scheme
11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine
844639-08-3

11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Stage #1: 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine With boron trichloride In toluene; xylene at -5 - 20℃; for 2h;
Stage #2: With triethylamine In methanol; toluene; xylene for 0.166667h;
Stage #3: With sodium hydroxide In methanol; water; toluene; xylene Product distribution / selectivity;
benzoic acid 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethoxy]-ethyl ester

benzoic acid 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethoxy]-ethyl ester

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Stage #1: benzoic acid 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethoxy]-ethyl ester With sodium hydroxide In ethanol; water at 80℃; for 2h;
Stage #2: With hydrogenchloride In water; ethyl acetate
Stage #3: With sodium hydroxide In water pH=12;
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
5747-48-8

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine

2-(2-hydroxyethoxy)acetaldehyde
17976-70-4

2-(2-hydroxyethoxy)acetaldehyde

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium tetrahydroborate; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h;
With magnesium borohydride; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h;
C6H10O4
870676-47-4

C6H10O4

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
5747-48-8

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium tetrahydroborate; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h;
11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 20℃; for 1.5h;
With sodium hydroxide In dichloromethane; water at 20℃; for 1.5h;
With ammonium hydroxide In water pH=9;170 mg
N-Dealkyl Quetiapine dihydrochloride

N-Dealkyl Quetiapine dihydrochloride

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In water at 100 - 105℃; for 9h; Product distribution / selectivity;
Stage #1: N-Dealkyl Quetiapine dihydrochloride; 2-(2-Chloroethoxy)ethanol
Stage #2: With 1-methyl-2-pyrrolidine; sodium carbonate; sodium iodide In toluene Further stages.;
11-[4-(2-methanesulphonylethyl)-1-piperazinyI]dibenzo[b,f][1,4]thiazepine

11-[4-(2-methanesulphonylethyl)-1-piperazinyI]dibenzo[b,f][1,4]thiazepine

ethylene glycol
107-21-1

ethylene glycol

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium hydride In toluene for 10 - 12h; Product distribution / selectivity; Heating / reflux;
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
5747-48-8

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine

tetrabutylammomium bromide
1643-19-2

tetrabutylammomium bromide

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With sodium carbonate In water; toluene
With sodium carbonate In water; toluene
With sodium carbonate In water; toluene
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride
1176987-11-3

dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride With N,N-dimethyl-cyclohexanamine at 155℃; for 58h;
Stage #2: With hydrogenchloride In dichloromethane; water for 1.5h; Heating / reflux;
Stage #3: With sodium hydroxide In water pH=13 - 14;
11-chloro-dibenzo[b,f][1,4]thiazepine
13745-86-3

11-chloro-dibenzo[b,f][1,4]thiazepine

1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride

1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
With potassium carbonate In sulfolane at 95 - 100℃; for 4h;
Stage #1: 11-chloro-dibenzo[b,f][1,4]thiazepine; 1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride With sodium carbonate; sodium iodide In toluene at 20℃; for 12h; Reflux;
Stage #2: With (2E)-but-2-enedioic acid In isopropyl alcohol for 1h; Reflux;
2‑(2‑nitrophenylsulfanyl)benzoic acid
19806-43-0

2‑(2‑nitrophenylsulfanyl)benzoic acid

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / dichloromethane / 40 °C
1.2: 0 - 5 °C
2.1: formic acid; iron / 85 - 90 °C
View Scheme
Thiosalicylic acid
147-93-3

Thiosalicylic acid

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; isopropyl alcohol / Inert atmosphere; Reflux
2.1: thionyl chloride / dichloromethane / 40 °C
2.2: 0 - 5 °C
3.1: formic acid; iron / 85 - 90 °C
View Scheme
2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; isopropyl alcohol / Inert atmosphere; Reflux
2.1: thionyl chloride / dichloromethane / 40 °C
2.2: 0 - 5 °C
3.1: formic acid; iron / 85 - 90 °C
View Scheme
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Quetiapine
111974-69-7

Quetiapine

quetiapine fumarate
111974-72-2

quetiapine fumarate

Conditions
ConditionsYield
In ethyl acetate; toluene at 20℃; for 1.08333h; Product distribution / selectivity; Heating / reflux;99%
Stage #1: Quetiapine With pyrographite In methanol for 0.5h; Reflux;
Stage #2: (2E)-but-2-enedioic acid at 40℃; pH=4 - 5;
98%
In methanol at 10 - 25℃; for 1.58333h; Heating / reflux;94%
Quetiapine
111974-69-7

Quetiapine

quetiapine N19-oxide

quetiapine N19-oxide

Conditions
ConditionsYield
Stage #1: Quetiapine With 3-chloro-benzenecarboperoxoic acid In chloroform at 23℃; for 0.166667h; Inert atmosphere;
Stage #2: With triethylamine In chloroform for 0.166667h; Inert atmosphere;
97%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Quetiapine
111974-69-7

Quetiapine

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

Conditions
ConditionsYield
In ethanol at 30 - 85℃; for 2.5h;96.4%
With sulfuric acid In ethanol at 20℃; for 8h;94%
In acetone at 20℃;
In methanol at 70 - 75℃; for 0.5h;
Stage #1: (2E)-but-2-enedioic acid; Quetiapine In methanol at 5 - 65℃; for 5.5h;
Stage #2: (2E)-but-2-enedioic acid In methanol at 60℃; Product distribution / selectivity;
2,3-O-isopropylidene-4-O-benzyl-α-L-rhamnopyranosyl diphenylphosphate

2,3-O-isopropylidene-4-O-benzyl-α-L-rhamnopyranosyl diphenylphosphate

Quetiapine
111974-69-7

Quetiapine

A

C37H45N3O6S

C37H45N3O6S

B

C37H45N3O6S

C37H45N3O6S

Conditions
ConditionsYield
With C53H57F11N6O4S2 In di-isopropyl ether at 50℃; for 48h; Molecular sieve; Sealed tube; Overall yield = 76 percent; Overall yield = 0.075 g; stereoselective reaction;A n/a
B 96%
Boc-Val-ONSu
3392-12-9

Boc-Val-ONSu

Quetiapine
111974-69-7

Quetiapine

Boc-Val-QTP
1314005-85-0

Boc-Val-QTP

Conditions
ConditionsYield
Stage #1: Quetiapine With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: Boc-Val-ONSu In tetrahydrofuran for 1h;
Stage #3: With ammonium chloride In tetrahydrofuran; water for 0.25h;
95%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Quetiapine
111974-69-7

Quetiapine

quetiapine fumarate

quetiapine fumarate

Conditions
ConditionsYield
In methanol; ethanol at 40 - 45℃;93.3%
In ethanol Reflux;79%
In isopropyl alcohol at 80 - 85℃; for 1.5h;
Stage #1: Quetiapine With pyrographite In butan-1-ol at 60 - 70℃; for 1.5h;
Stage #2: (2E)-but-2-enedioic acid In butan-1-ol at 20 - 60℃; for 2.5 - 3h; Product distribution / selectivity;
In isopropyl alcohol for 1h; Heating / reflux;
oxalic acid
144-62-7

oxalic acid

Quetiapine
111974-69-7

Quetiapine

quetiapine oxalate

quetiapine oxalate

Conditions
ConditionsYield
In acetone; toluene at 25℃; for 1.08333h; Heating / reflux;89%
In ethanol at 0 - 20℃; for 4h; Heating / reflux;
Quetiapine
111974-69-7

Quetiapine

quetiapine N19,S-dioxide

quetiapine N19,S-dioxide

Conditions
ConditionsYield
With dihydrogen peroxide In water at 23℃; for 18h; Cooling with ice; Inert atmosphere;87%
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere
1.2: 0.17 h / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere
2.2: 0.17 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere
1.2: 0.17 h / Inert atmosphere
2.1: osmium(VIII) oxide / water; tert-butyl alcohol / 19 h / 20 °C / Inert atmosphere
View Scheme
acrylonitrile
107-13-1

acrylonitrile

Quetiapine
111974-69-7

Quetiapine

3-(2-(2-(4-(dibenzo[b,f]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)propanenitrile
1606176-56-0

3-(2-(2-(4-(dibenzo[b,f]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)propanenitrile

Conditions
ConditionsYield
With n-butyllithium; copper(I) 2-hydroxy-3-methylbenzoate; benzylamine; 1,2-bis-(diphenylphosphino)ethane In tetrahydrofuran at 4℃; for 1h; Inert atmosphere; chemoselective reaction;84%
Phosphoric acid diphenyl ester (2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

Phosphoric acid diphenyl ester (2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

Quetiapine
111974-69-7

Quetiapine

C55H59N3O7S

C55H59N3O7S

Conditions
ConditionsYield
With (S)-4-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-5-((R)-2-(4-fluorophenyl)-2-methylpyrrolidin-1-yl)-3,3-dimethyl-5-oxopentyl 3-(3-((S)-1-((R)-2-(4-fluorophenyl)-2-methylpyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thioureido)-5-(trifluoromethyl)benzoate In di-isopropyl ether at 40℃; for 19h; Molecular sieve; Sealed tube; stereoselective reaction;72%
2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl diphenylphosphate

2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl diphenylphosphate

Quetiapine
111974-69-7

Quetiapine

2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol-(2,3:4,6-di-O-isopropylidene-β-D-mannopyranose)

2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol-(2,3:4,6-di-O-isopropylidene-β-D-mannopyranose)

Conditions
ConditionsYield
With C53H57F11N6O4S2 In di-isopropyl ether at 50℃; for 48h; Molecular sieve; Sealed tube; stereoselective reaction;63%
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

Quetiapine
111974-69-7

Quetiapine

C28H28N4O6S

C28H28N4O6S

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 22℃; for 20h; Inert atmosphere;32%
Quetiapine
111974-69-7

Quetiapine

quetiapine fumarate

quetiapine fumarate

Conditions
ConditionsYield
With (2E)-but-2-enedioic acid In acetone at 20 - 25℃; for 1h;
With (2E)-but-2-enedioic acid In ethyl acetate at 20 - 25℃; for 1h;
With (2E)-but-2-enedioic acid In tert-butyl methyl ether for 1.25h; Heating / reflux;
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