We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:111974-69-7
Min.Order:1 Gram
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Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:111974-69-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day
Cas:111974-69-7
Min.Order:1 Kilogram
FOB Price: $4.0
Type:Lab/Research institutions
inquiryChemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service Quetiapine CAS 111974-69-7 IN Stock 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol 111974-69-7 111974-69-
Cas:111974-69-7
Min.Order:5 Kiloliter
FOB Price: $3.5 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:111974-69-7
Min.Order:1 Gram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:111974-69-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAppearance:white crystalline powder Storage:Store at -20°C Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China
Cas:111974-69-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:111974-69-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:111974-69-7
Min.Order:1 Kilogram
FOB Price: $47.0 / 52.0
Type:Trading Company
inquiryQuetiapine CAS:111974-69-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:111974-69-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:111974-69-7
Min.Order:1 Kilogram
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:111974-69-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryQuetiapineAppearance:white crystalline Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:111974-69-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:111974-69-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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Min.Order:0
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:111974-69-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:111974-69-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:111974-69-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:111974-69-7
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:111974-69-7
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:111974-69-7
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryAppearance :White or almost white powder Conforms Solubility Slightly soluble in water, in anhydrous ethanol and in methanol. …Appearance:White or almost white powder Storage:cool and dry Package:25kg/drum Application:Antipsych
1-[2-(2-hydroxyethoxy)ethyl]piperazine
11-chloro-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
In toluene at 105 - 107℃; | 99% |
In toluene at 110 - 120℃; for 8h; Product distribution / selectivity; | 98% |
In toluene Reflux; | 92% |
11-chloro-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; 4-phenyl-N-methylpyridinium iodide; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc In dimethyl sulfoxide at 80℃; for 8h; Reagent/catalyst; Inert atmosphere; | 99% |
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride
2-(2-Chloroethoxy)ethanol
Quetiapine
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide; tetrabutylammomium bromide In toluene at 115 - 120℃; for 17h; Heating / reflux; | 98.2% |
With sodium carbonate; sodium iodide; tetrabutylammomium bromide In butan-1-ol at 115 - 120℃; for 17h; Heating / reflux; | 96.9% |
With sodium carbonate; sodium iodide In butan-1-ol at 115 - 120℃; for 17h; Heating / reflux; | 94.1% |
Quetiapine
Conditions | Yield |
---|---|
Stage #1: 11-{4-[2-(2-tritiloxiethoxy)ethyl]piperazine-1-yl}dibenzo[b,f][1,4]thiazepine With toluene-4-sulfonic acid In methanol; toluene for 4h; Heating / reflux; Stage #2: With hydrogenchloride In water; toluene Stage #3: With sodium hydroxide In water; toluene pH=9.5; Product distribution / selectivity; | 95% |
2-nitro-2'-[4-[2-(2-hydroxyethoxy)ethyl]-piperazinylcarbonyl]diphenylsulfide
Quetiapine
Conditions | Yield |
---|---|
With formic acid; iron at 85 - 90℃; | 94.5% |
11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
Stage #1: 11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine With potassium hydroxide In methanol at 20 - 25℃; for 3h; Stage #2: With hydrogenchloride In water Stage #3: With sodium hydroxide In water pH=10; Product distribution / selectivity; | 94% |
With sodium hydroxide In ethanol; water at 20℃; for 0.5h; | |
With sodium hydroxide; water In methanol at 160℃; |
dibenzo[b,f][1,4]thiazepin-11-one
Quetiapine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: POCl3; N,N-dimethylaniline / 4 h / Heating 2: xylene / Heating View Scheme | |
Multi-step reaction with 2 steps 1: pyrophosphoryl chloride; N,N-dimethyl-aniline / toluene / 4.5 h / 110 - 112 °C / Green chemistry 2: toluene / 105 - 107 °C View Scheme |
11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
Stage #1: 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine With boron trichloride In toluene; xylene at -5 - 20℃; for 2h; Stage #2: With triethylamine In methanol; toluene; xylene for 0.166667h; Stage #3: With sodium hydroxide In methanol; water; toluene; xylene Product distribution / selectivity; |
Quetiapine
Conditions | Yield |
---|---|
Stage #1: benzoic acid 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethoxy]-ethyl ester With sodium hydroxide In ethanol; water at 80℃; for 2h; Stage #2: With hydrogenchloride In water; ethyl acetate Stage #3: With sodium hydroxide In water pH=12; |
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
2-(2-hydroxyethoxy)acetaldehyde
Quetiapine
Conditions | Yield |
---|---|
With sodium tetrahydroborate; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h; | |
With magnesium borohydride; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; sodium acetate In water; acetic acid at 0 - 10℃; for 1.66667h; |
Quetiapine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 20℃; for 1.5h; | |
With sodium hydroxide In dichloromethane; water at 20℃; for 1.5h; | |
With ammonium hydroxide In water pH=9; | 170 mg |
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In water at 100 - 105℃; for 9h; Product distribution / selectivity; | |
Stage #1: N-Dealkyl Quetiapine dihydrochloride; 2-(2-Chloroethoxy)ethanol Stage #2: With 1-methyl-2-pyrrolidine; sodium carbonate; sodium iodide In toluene Further stages.; |
ethylene glycol
Quetiapine
Conditions | Yield |
---|---|
With sodium hydride In toluene for 10 - 12h; Product distribution / selectivity; Heating / reflux; |
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
tetrabutylammomium bromide
2-(2-Chloroethoxy)ethanol
Quetiapine
Conditions | Yield |
---|---|
With sodium carbonate In water; toluene | |
With sodium carbonate In water; toluene | |
With sodium carbonate In water; toluene |
1-[2-(2-hydroxyethoxy)ethyl]piperazine
dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride
Quetiapine
Conditions | Yield |
---|---|
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride With N,N-dimethyl-cyclohexanamine at 155℃; for 58h; Stage #2: With hydrogenchloride In dichloromethane; water for 1.5h; Heating / reflux; Stage #3: With sodium hydroxide In water pH=13 - 14; |
11-chloro-dibenzo[b,f][1,4]thiazepine
Quetiapine
Conditions | Yield |
---|---|
With potassium carbonate In sulfolane at 95 - 100℃; for 4h; | |
Stage #1: 11-chloro-dibenzo[b,f][1,4]thiazepine; 1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride With sodium carbonate; sodium iodide In toluene at 20℃; for 12h; Reflux; Stage #2: With (2E)-but-2-enedioic acid In isopropyl alcohol for 1h; Reflux; |
2‑(2‑nitrophenylsulfanyl)benzoic acid
Quetiapine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride / dichloromethane / 40 °C 1.2: 0 - 5 °C 2.1: formic acid; iron / 85 - 90 °C View Scheme |
Thiosalicylic acid
Quetiapine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water; isopropyl alcohol / Inert atmosphere; Reflux 2.1: thionyl chloride / dichloromethane / 40 °C 2.2: 0 - 5 °C 3.1: formic acid; iron / 85 - 90 °C View Scheme |
2-Chloronitrobenzene
Quetiapine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water; isopropyl alcohol / Inert atmosphere; Reflux 2.1: thionyl chloride / dichloromethane / 40 °C 2.2: 0 - 5 °C 3.1: formic acid; iron / 85 - 90 °C View Scheme |
Conditions | Yield |
---|---|
In ethyl acetate; toluene at 20℃; for 1.08333h; Product distribution / selectivity; Heating / reflux; | 99% |
Stage #1: Quetiapine With pyrographite In methanol for 0.5h; Reflux; Stage #2: (2E)-but-2-enedioic acid at 40℃; pH=4 - 5; | 98% |
In methanol at 10 - 25℃; for 1.58333h; Heating / reflux; | 94% |
Quetiapine
Conditions | Yield |
---|---|
Stage #1: Quetiapine With 3-chloro-benzenecarboperoxoic acid In chloroform at 23℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In chloroform for 0.166667h; Inert atmosphere; | 97% |
(2E)-but-2-enedioic acid
Quetiapine
Conditions | Yield |
---|---|
In ethanol at 30 - 85℃; for 2.5h; | 96.4% |
With sulfuric acid In ethanol at 20℃; for 8h; | 94% |
In acetone at 20℃; | |
In methanol at 70 - 75℃; for 0.5h; | |
Stage #1: (2E)-but-2-enedioic acid; Quetiapine In methanol at 5 - 65℃; for 5.5h; Stage #2: (2E)-but-2-enedioic acid In methanol at 60℃; Product distribution / selectivity; |
Quetiapine
Conditions | Yield |
---|---|
With C53H57F11N6O4S2 In di-isopropyl ether at 50℃; for 48h; Molecular sieve; Sealed tube; Overall yield = 76 percent; Overall yield = 0.075 g; stereoselective reaction; | A n/a B 96% |
Conditions | Yield |
---|---|
Stage #1: Quetiapine With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.5h; Stage #2: Boc-Val-ONSu In tetrahydrofuran for 1h; Stage #3: With ammonium chloride In tetrahydrofuran; water for 0.25h; | 95% |
Conditions | Yield |
---|---|
In methanol; ethanol at 40 - 45℃; | 93.3% |
In ethanol Reflux; | 79% |
In isopropyl alcohol at 80 - 85℃; for 1.5h; | |
Stage #1: Quetiapine With pyrographite In butan-1-ol at 60 - 70℃; for 1.5h; Stage #2: (2E)-but-2-enedioic acid In butan-1-ol at 20 - 60℃; for 2.5 - 3h; Product distribution / selectivity; | |
In isopropyl alcohol for 1h; Heating / reflux; |
Conditions | Yield |
---|---|
In acetone; toluene at 25℃; for 1.08333h; Heating / reflux; | 89% |
In ethanol at 0 - 20℃; for 4h; Heating / reflux; |
Quetiapine
Conditions | Yield |
---|---|
With dihydrogen peroxide In water at 23℃; for 18h; Cooling with ice; Inert atmosphere; | 87% |
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere 1.2: 0.17 h / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere 2.2: 0.17 h / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / 23 °C / Inert atmosphere 1.2: 0.17 h / Inert atmosphere 2.1: osmium(VIII) oxide / water; tert-butyl alcohol / 19 h / 20 °C / Inert atmosphere View Scheme |
acrylonitrile
Quetiapine
3-(2-(2-(4-(dibenzo[b,f]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)propanenitrile
Conditions | Yield |
---|---|
With n-butyllithium; copper(I) 2-hydroxy-3-methylbenzoate; benzylamine; 1,2-bis-(diphenylphosphino)ethane In tetrahydrofuran at 4℃; for 1h; Inert atmosphere; chemoselective reaction; | 84% |
Quetiapine
Conditions | Yield |
---|---|
With (S)-4-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-5-((R)-2-(4-fluorophenyl)-2-methylpyrrolidin-1-yl)-3,3-dimethyl-5-oxopentyl 3-(3-((S)-1-((R)-2-(4-fluorophenyl)-2-methylpyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thioureido)-5-(trifluoromethyl)benzoate In di-isopropyl ether at 40℃; for 19h; Molecular sieve; Sealed tube; stereoselective reaction; | 72% |
Quetiapine
Conditions | Yield |
---|---|
With C53H57F11N6O4S2 In di-isopropyl ether at 50℃; for 48h; Molecular sieve; Sealed tube; stereoselective reaction; | 63% |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 22℃; for 20h; Inert atmosphere; | 32% |
Quetiapine
Conditions | Yield |
---|---|
With (2E)-but-2-enedioic acid In acetone at 20 - 25℃; for 1h; | |
With (2E)-but-2-enedioic acid In ethyl acetate at 20 - 25℃; for 1h; | |
With (2E)-but-2-enedioic acid In tert-butyl methyl ether for 1.25h; Heating / reflux; |
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