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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

1-Hydroxyethylethoxypiperazine Manufacturer/High quality/Best price/In stock CAS NO.13349-82-1

Cas:13349-82-1

Min.Order:1 Liter

FOB Price: $160.0 / 180.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1-Hydroxyethylethoxypiperazine Manufacturer/High quality/Best price/In stock

Cas:13349-82-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 1-Hydroxyethylethoxypiperazine supplier in China

Cas:13349-82-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 1-Hydroxyethylethoxypiperazine CAS number 13349-82-1 Assay ≥99% Appearance Yellow liquid Capacity 500mt/year Application Pharmaceutical int

1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

1-Hydroxyethylethoxypiperazine[CAS:13349-82-1] Quetiapine Intermediate 11-Piperazinodibenzo[b,f][1,4]Thiazepine Dihydrochloride[CAS:111974-74-4] 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine[CAS:3159-07-7] HANGZHOU THINK CHEMIC

High purity 1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-[2-(Piperazin-1-yl)ethoxy]ethanol

Cas:13349-82-1

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-[2-(2-Hydroxyethoxy)-ethyl]-piperazine

Cas:13349-82-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:1-Hydroxyethylethoxypiperazine CAS NO:13349-82-1 Grade:Medical scientific research and export Molecular formula:C8H20N2O2 Molecular weight:176.2555 Product Quality 12 years of chemical raw materials Mature operation of the industry Sy

1-Hydroxyethylethoxypiperazine/ CAS:13349-82-1/raw material/ high-quality

Cas:13349-82-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Factory Supply 1-Hydroxyethylethoxypiperazine CAS 13349-82-1

Cas:13349-82-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

CAS No.628-89-7 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scie

CAS No.13349-82-1 1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 13349-82-1 with best quality

Cas:13349-82-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material 1-Hydroxyethylethoxypiperazine CAS 13349-82-1

Cas:13349-82-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-Hydroxyethylethoxypiperazine/ LIDE PHARMA- Factory supply / Best price

Cas:13349-82-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name 1-Hydroxyethylethoxypiperazine CAS 13349-82-1 Synonyms 1-piperazidine;1-Hydroxyethylethoxypiperazine, 95% 5ML;Ethanol, 2-[2-(1-piperazinyl)ethoxy]-;Quetiapine IMpuri

1-Hydroxyethoxyethylpiperazine

Cas:13349-82-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Hydroxyethylethoxypiperazine 13349-82-1

Cas:13349-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1-Hydroxyethylethoxypiperazine CAS:13349-82-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or

1-Hydroxyethylethoxypiperazine CAS:13349-82-1

Cas:13349-82-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-[2-(2-Hydroxyethoxy)-ethyl]-piperazine

Cas:13349-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists

1-Hydroxyethylethoxyp iperazine 13349-82-1

Cas:13349-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 1-Hydroxyethylethoxypiperazine Synonyms: China HEP crystal hot selling kf-wang(at)kf-chem.com;HEP crystal high quality and low price new replacement product kf-wang(at)kf-chem.com;Quetiapine Impurity (1-[2-(2-Hydroxyethoxy);N-HYDRO

1-Hydroxyethylethoxypiperazine supplier best quality

Cas:13349-82-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

1-Hydroxyethoxyethylpiperazine

Cas:13349-82-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-[2-(2-Hydroxyethoxy)ethyl]piperazine. 2HCl

Cas:13349-82-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

QUETIAPINE FUMARATE INTERMEDIATES

Cas:13349-82-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1- 2-(2-Hydroxyethoxyl)-ethyl piperazine

Cas:13349-82-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

1-Hydroxyethylethoxypiperazine/High quality/Best price

Cas:13349-82-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 1-Hydroxyethylethoxypiperazine

Cas:13349-82-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

1-[2-(2-Hydroxyethoxy) Ethyl] PiperazineAppearance:Colorless transparent liquid Storage:Keep away of light, cool place Package:according to customers' requirements Application:pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or

1-[2-(2-Hydroxyethoxy) Ethyl] Piperazine

Cas:13349-82-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

piperazine
110-85-0

piperazine

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
ConditionsYield
With piperazine dihydrochloride In ethanol for 10h; Reflux; Large scale;95.1%
at 120 - 140℃; for 1h;70%
tert-butyl 4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate
166388-52-9

tert-butyl 4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 2h;95%
With trifluoroacetic acid In dichloromethane at 20℃; for 1h;80%
C17H34N4O4S

C17H34N4O4S

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
ConditionsYield
With dipotassium peroxodisulfate at 30 - 60℃; for 6h; Reagent/catalyst;80.5%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
ConditionsYield
With potassium hydroxide; ethanol
Quetiapine
111974-69-7

Quetiapine

A

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

B

2-[2-(4,5-dihydro-1H-imidazol-1-yl)ethoxy]ethanol

2-[2-(4,5-dihydro-1H-imidazol-1-yl)ethoxy]ethanol

C

2-[2-(1-oxidopiperazin-1-yl)ethoxy]ethanol
1216996-50-7

2-[2-(1-oxidopiperazin-1-yl)ethoxy]ethanol

D

dibenzo[b,f]-1,4-thiazepine
257-15-8

dibenzo[b,f]-1,4-thiazepine

E

Quetiapine sulfoxide

Quetiapine sulfoxide

Conditions
ConditionsYield
In methanol at 25℃; for 6h; Kinetics; UV-irradiation;
2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

2-(2-Aminoethoxy)ethanol
929-06-6

2-(2-Aminoethoxy)ethanol

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
ConditionsYield
With hydrogen at 180℃; under 150015 Torr; for 15h;
With hydrogen at 180℃; under 750.075 - 150015 Torr; Time;
With hydrogen at 180℃; under 150015 Torr; for 15h;
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]
1067884-35-8

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]

(2'Z-3'E)-6-bromoindirubin-3'-[O-(2-{4-[2-(2-hydroxyethoxy)-ethyl]piperazin-1-yl}ethyl)oxime]
1067884-49-4

(2'Z-3'E)-6-bromoindirubin-3'-[O-(2-{4-[2-(2-hydroxyethoxy)-ethyl]piperazin-1-yl}ethyl)oxime]

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃;100%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

acrylonitrile
107-13-1

acrylonitrile

3-{4-[2-(2-hydroxy-ethoxy)ethyl]-piperazin-1-yl}-propionitrile
1278584-73-8

3-{4-[2-(2-hydroxy-ethoxy)ethyl]-piperazin-1-yl}-propionitrile

Conditions
ConditionsYield
at 20℃; for 72h; Michael addition;100%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

11-chloro-dibenzo[b,f][1,4]thiazepine
13745-86-3

11-chloro-dibenzo[b,f][1,4]thiazepine

Quetiapine
111974-69-7

Quetiapine

Conditions
ConditionsYield
In toluene at 105 - 107℃;99%
In toluene at 110 - 120℃; for 8h; Product distribution / selectivity;98%
In toluene Reflux;92%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

(S)-N-[(3-bromo-propyl)(oxido)phenyl-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
1027727-66-7

(S)-N-[(3-bromo-propyl)(oxido)phenyl-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

(S)-N-[(3-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}propyl)(oxido)phenyl-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
1027727-68-9

(S)-N-[(3-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}propyl)(oxido)phenyl-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 0.5h;96%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

11-chlorodibenzo[b,f][1,4]thiazepin-11-one

11-chlorodibenzo[b,f][1,4]thiazepin-11-one

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

Conditions
ConditionsYield
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; 11-chlorodibenzo[b,f][1,4]thiazepin-11-one With potassium carbonate In toluene for 5h; Reflux; Large scale;
Stage #2: (2E)-but-2-enedioic acid In ethanol for 1.5h; Reflux; Large scale;
95.3%
2,2-dimethylthiirane
3772-13-2

2,2-dimethylthiirane

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

2-(2-{4-[2-Methyl-2-sulfanylpropyl]piperazinyl}ethoxy)ethan-1-ol

2-(2-{4-[2-Methyl-2-sulfanylpropyl]piperazinyl}ethoxy)ethan-1-ol

Conditions
ConditionsYield
at 80℃; for 4h;93%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate
166388-52-9

tert-butyl 4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 12h;92%
In dichloromethane at 0 - 20℃;92%
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 12h;92%
In dichloromethane at 20℃;
With triethylamine In dichloromethane at 20℃; for 12h;
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

2-(4-chloro-3-nitrophenyl)-3-hydroxyquinoline-4(1H)-one
1011306-89-0

2-(4-chloro-3-nitrophenyl)-3-hydroxyquinoline-4(1H)-one

3-hydroxy-2-(4-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}-3-nitrophenyl)quinolin-4(1H)-one

3-hydroxy-2-(4-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}-3-nitrophenyl)quinolin-4(1H)-one

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one at 110℃; for 2h;91%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione
835616-61-0

2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)isoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 90℃; for 3h;89.8%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

2‑(2‑nitrophenylsulfanyl)benzoic acid
19806-43-0

2‑(2‑nitrophenylsulfanyl)benzoic acid

2-nitro-2'-[4-[2-(2-hydroxyethoxy)ethyl]-piperazinylcarbonyl]diphenylsulfide
849790-30-3

2-nitro-2'-[4-[2-(2-hydroxyethoxy)ethyl]-piperazinylcarbonyl]diphenylsulfide

Conditions
ConditionsYield
Stage #1: 2‑(2‑nitrophenylsulfanyl)benzoic acid With thionyl chloride In dichloromethane at 40℃;
Stage #2: 1-[2-(2-hydroxyethoxy)ethyl]piperazine With triethylamine In dichloromethane at 0 - 5℃;
89.7%
Stage #1: 2‑(2‑nitrophenylsulfanyl)benzoic acid With 4-methyl-morpholine; triethylamine In dichloromethane at 20℃; for 0.25h;
Stage #2: 1-[2-(2-hydroxyethoxy)ethyl]piperazine With pivaloyl chloride In dichloromethane
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

carbon disulfide
75-15-0

carbon disulfide

t-butyl bromide
507-19-7

t-butyl bromide

4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine-1-carbodithioic acid tert-butyl ester

4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine-1-carbodithioic acid tert-butyl ester

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; caesium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;89%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

(3E)-6-fluoro-3-[4-(2-fluoropyridin-4-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

(3E)-6-fluoro-3-[4-(2-fluoropyridin-4-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

(3E)-6-fluoro-3-[4-(2-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}pyridin-4-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

(3E)-6-fluoro-3-[4-(2-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}pyridin-4-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
In dimethyl sulfoxide at 105℃; for 6h;89%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

6,7-difluoro-3-hydroxy-2-phenylquinolin-4(1H)-one

6,7-difluoro-3-hydroxy-2-phenylquinolin-4(1H)-one

7-fluoro-3-hydroxy-6-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)2-phenylquinolin-4(1H)-one

7-fluoro-3-hydroxy-6-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)2-phenylquinolin-4(1H)-one

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one for 3h; Reflux;89%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

2-(2-(4-(pyrazin-2-yl)piperazin-1-yl)ethoxy)ethan-1-ol

2-(2-(4-(pyrazin-2-yl)piperazin-1-yl)ethoxy)ethan-1-ol

Conditions
ConditionsYield
With iodine; sodium acetate In acetonitrile at 70℃;88%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid
902148-42-9

13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6-[[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6-[[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Conditions
ConditionsYield
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h;87%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

C66H84Cl8N34

C66H84Cl8N34

C98H152Cl4N42O8

C98H152Cl4N42O8

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane at -20 - 20℃;85%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

N-hydroxyethyl-4-bromine-1,8-naphthalimide
52559-37-2

N-hydroxyethyl-4-bromine-1,8-naphthalimide

N-(2-hydroxyethyl)-4-(4-[2-(2-hydroxyethoxy)ethyl]-piperazine-1-yl)-1,8-naphthalimide

N-(2-hydroxyethyl)-4-(4-[2-(2-hydroxyethoxy)ethyl]-piperazine-1-yl)-1,8-naphthalimide

Conditions
ConditionsYield
In 2-methoxy-ethanol at 130℃; for 1h; Microwave irradiation; Inert atmosphere;85%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

6-bromo-2-(2-methoxyethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
651768-37-5

6-bromo-2-(2-methoxyethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

N-(2-methoxyethyl)-4-(4-[2-(2-Hydroxyethoxy)ethyl]-piperazine-1-yl)-1,8-naphthalimide

N-(2-methoxyethyl)-4-(4-[2-(2-Hydroxyethoxy)ethyl]-piperazine-1-yl)-1,8-naphthalimide

Conditions
ConditionsYield
In 2-methoxy-ethanol at 130℃; for 1h; Microwave irradiation; Inert atmosphere;85%
2-iodopyridine
5029-67-4

2-iodopyridine

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

A

C13H21O2N3

C13H21O2N3

B

1-(2-(2-(pyridin-2-yloxy)ethoxy)ethyl)piperazine

1-(2-(2-(pyridin-2-yloxy)ethoxy)ethyl)piperazine

Conditions
ConditionsYield
With 2-(2-methyl-1-oxopropyl)cyclohexanone; caesium carbonate; copper(l) iodide In N,N-dimethyl-formamide at 20℃; for 16h;A 83%
B n/a
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride
1176987-11-3

dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

quetiapine fumarate
111974-72-2

quetiapine fumarate

Conditions
ConditionsYield
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride at 172 - 176℃; for 5h;
Stage #2: In water at 20 - 65℃;
Stage #3: (2E)-but-2-enedioic acid In isopropyl alcohol at 4 - 20℃; Product distribution / selectivity;
83%
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; dibenzo[b,f][1,4]thiazepin-11-ylamine hydrochloride at 173 - 175℃; for 5h;
Stage #2: With potassium carbonate In water at 20 - 75℃;
Stage #3: (2E)-but-2-enedioic acid In isopropyl alcohol at 4 - 20℃; Product distribution / selectivity;
79%
2-iodopyridine
5029-67-4

2-iodopyridine

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

1-(2-(2-(pyridin-2-yloxy)ethoxy)ethyl)piperazine

1-(2-(2-(pyridin-2-yloxy)ethoxy)ethyl)piperazine

Conditions
ConditionsYield
With 3,4,7,8-Tetramethyl-o-phenanthrolin; 3 A molecular sieve; caesium carbonate; copper(l) iodide at 90℃; for 20h;82%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

5-chloro-2-bromomethyl-9H-xanthen-9-one
76967-95-8

5-chloro-2-bromomethyl-9H-xanthen-9-one

5-chloro-2-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)-9H-xanthen-9-one dihydrochloride

5-chloro-2-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)-9H-xanthen-9-one dihydrochloride

Conditions
ConditionsYield
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; 5-chloro-2-bromomethyl-9H-xanthen-9-one With potassium carbonate In toluene at 110℃; for 72h;
Stage #2: With hydrogenchloride In ethanol; water
82%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

benzyl(bromo)zinc
62673-31-8

benzyl(bromo)zinc

benzaldehyde
100-52-7

benzaldehyde

2-(2-(4-(1,2-diphenylethyl)piperazin-1-yl)ethoxy)ethanol

2-(2-(4-(1,2-diphenylethyl)piperazin-1-yl)ethoxy)ethanol

Conditions
ConditionsYield
In acetonitrile at 20℃; for 4h;80%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

1-(7-chloroquinolin-4-yl)-3-(3-nitrophenyl)thiourea

1-(7-chloroquinolin-4-yl)-3-(3-nitrophenyl)thiourea

1-(7-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)quinolin-4-yl)-3-(3-nitrophenyl)thiourea

1-(7-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)quinolin-4-yl)-3-(3-nitrophenyl)thiourea

Conditions
ConditionsYield
With copper In water at 100℃; Sealed tube;79%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

N-[(3-bromopropyl)(methyl)oxido-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

N-[(3-bromopropyl)(methyl)oxido-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

N-[(3-{4-[2-(2-hydroxyethoxyl)ethyl]piperazin-1-yl}propyl)(methyl)oxido-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

N-[(3-{4-[2-(2-hydroxyethoxyl)ethyl]piperazin-1-yl}propyl)(methyl)oxido-λ4-sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60℃; for 0.666667h;78%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

5-bromo-2-furancarboxaldehyde
1899-24-7

5-bromo-2-furancarboxaldehyde

N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

A

C18H25N3O4
355003-04-2

C18H25N3O4

B

C23H25N3O5
1017832-31-3

C23H25N3O5

Conditions
ConditionsYield
Stage #1: 1-[2-(2-hydroxyethoxy)ethyl]piperazine; 5-bromo-2-furancarboxaldehyde With triethylamine In 1,4-dioxane; water for 4h; Heating;
Stage #2: N-phenyl-maleimide With magnesium sulfate In 1,4-dioxane; water for 18h; Diels-Alder reaction; Heating; Further stages.;
A n/a
B 77%
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

tert-butyl 2-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)acetate

tert-butyl 2-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)acetate

Conditions
ConditionsYield
With triethanolamine In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 16h;77%

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