DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:3159-07-7
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1180.html Product Name 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine
Cas:3159-07-7
Min.Order:1 Gram
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inquiryTIANFUCHEM--3159-07-7--10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had estab
Cas:3159-07-7
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:3159-07-7
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Other Name:Quetiapine intermediate CAS No:3159-07-7 MF: C13H9NOS Molecular weight:227.28 Grade Standard: Medicine Grade Purity: 99%min Appearance:white powder 10,11-Dihydro-11-oxodi
Cas:3159-07-7
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS:3159-07-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
Cas:3159-07-7
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:3159-07-7
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inquiryProduct Name: 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Synonyms: 11-Oxo-10,11-dihydro-Dibenzo[b,f][1,4]thiazepine;10H-DIBENZO-(1,4)-THIAZEPINE-11-ONE;10,11-DIHYDRO-11-OXODIBENZO[B,F][1,4]THIAZEPINE;DIBENZO[B,F][1,4]THIAZEPINE-11-[10H]ONE;
Cas:3159-07-7
Min.Order:100 Gram
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:3159-07-7
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcin
Cas:3159-07-7
Min.Order:100 Metric Ton
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:3159-07-7
Min.Order:100 Gram
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:3159-07-7
Min.Order:1 Kilogram
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:3159-07-7
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:3159-07-7
Min.Order:4 Kilogram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:3159-07-7
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:3159-07-7
Min.Order:10 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate
Cas:3159-07-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:3159-07-7
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryProduct name: Dibenzo[b,f][1,4]Thiazepine-11-[10H]one CAS No.:3159-07-7 Molecule Formula:C13H9NOS Molecule Weight:227.28 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
Cas:3159-07-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:3159-07-7
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:3159-07-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry2-phenylthiophenyl isocyanate
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
aluminum (III) chloride In 1,2-dichloro-benzene at 100 - 150℃; for 4h; | 100% |
phenyl [2-(phenylsulphanyl)phenyl]carbamate
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With methanesulfonic acid; phosphorus pentoxide at 80 - 110℃; for 2.5h; | 96% |
With polyphosphoric acid Heating; | 94% |
With PPA In water | 87% |
2-((2-aminophenyl)thio)benzoic acid
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With PPA at 140℃; for 2h; | 95% |
toluene-4-sulfonic acid In ethyl acetate; xylene at 125℃; for 10h; | 86% |
With phosphorus pentoxide; xylene |
bis(trichloromethyl) carbonate
2-aminodiphenyl sulfide hydrochloride
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; 2-aminodiphenyl sulfide hydrochloride In chloroform for 10h; Reflux; Large scale; Stage #2: With toluene-4-sulfonic acid In chloroform at 120℃; for 3h; Large scale; | 93.7% |
Conditions | Yield |
---|---|
With acetic acid; zinc Reagent/catalyst; Reflux; | 93.4% |
Stage #1: methyl 2-(2-nitrophenylthio)[14C]benzoate With tin(II) chloride dihdyrate In ethanol Stage #2: With trimethylaluminum In dichloromethane at 45 - 100℃; | 40% |
Multi-step reaction with 2 steps 1: ethyl acetate; Raney nickel / Hydrogenation 2: 220 °C View Scheme | |
Multi-step reaction with 2 steps 1: Raney nickel; ethanol / Hydrogenation 2: 220 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: iron(III) chloride; pyrographite / 0.5 h / 65 °C 1.2: 12 h / 65 °C 2.1: sodium methylate / toluene / 24 h / 110 °C View Scheme |
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 1500.15 Torr; Reagent/catalyst; | 85.4% |
9H-thioxanthen-9-one oxime
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Reagent/catalyst; Solvent; Reflux; | 81.5% |
With phosphorus pentachloride In diethyl ether Ambient temperature; |
2-(2-nitrophenylthio)benzoic acid methyl ester
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With sodium methylate In toluene at 110℃; for 24h; Temperature; Reagent/catalyst; | 80.1% |
With acetic acid at 135℃; | 72% |
at 220℃; |
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With sodium methylate In toluene at 110℃; for 24h; | 79.6% |
carbon monoxide
(2-aminophenyl)-2’-bromophenyl sulfide
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With dmap; bis(dibenzylideneacetone)-palladium(0); catacxium A In toluene at 100℃; for 18h; Sealed tube; | 76% |
2-iodophenylamine
Methyl thiosalicylate
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With rongalite; sodium hydroxide In dimethyl sulfoxide at 90℃; for 48h; Inert atmosphere; Schlenk technique; Sealed tube; | 70% |
2-phenylsulfanyl-aniline
phenyl chloroformate
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With sodium carbonate In toluene | 62% |
o-iodo-methyl-benzoic acid
2-amino-benzenethiol
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With copper(II) ferrite; potassium tert-butylate In N,N-dimethyl-formamide for 24h; Reflux; Inert atmosphere; | 60% |
2-(2-trifluoroacetylaminophenylthio)benzoic acid
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With trifluoroacetic anhydride In N,N-dimethyl-formamide 1.) reflux, 1 h, 2.) RT, overnight; | 55% |
2‑(2‑nitrophenylsulfanyl)benzoic acid
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With tributylphosphine at 140℃; for 48h; Schlenk technique; regioselective reaction; | 51% |
Multi-step reaction with 2 steps 1: ethyl acetate 2: triethylamine; benzotriazol-1-ol / dichloromethane View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 12 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
In tert-butyl alcohol for 2h; Irradiation; | 31% |
In tert-butyl alcohol for 1.5h; Irradiation; | 31% |
2-chloro-3-aminopyridine
Thiosalicylic acid
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
In 1,2-dichloro-benzene for 0.8h; Reflux; | 26% |
Conditions | Yield |
---|---|
With oxygen In benzene for 2h; Product distribution; Irradiation; other solvents; without oxygen.; | A 15% B 8% |
With N-chloro-succinimide; potassium hydrogencarbonate 1) CH2Cl2, 0 deg C, 20 min; 2) water, 1 h.; Yield given. Multistep reaction; |
carbon dioxide
2-phenylsulfanyl-aniline
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With n-butyllithium 1) ether, room temperature, 30 h, 2) ether; Yield given. Multistep reaction; |
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dioxane / 18 h / Ambient temperature 2: 55 percent / trifluoroacetic anhydride / dimethylformamide / 1.) reflux, 1 h, 2.) RT, overnight View Scheme |
2,2'-dithiodibenzoic acid dichloride
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2) bromine; 3) basic alumina 2: 31 percent / 2-methyl-propan-2-ol / 2 h / Irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2) bromine; 3) basic alumina 2: 31 percent / 2-methyl-propan-2-ol / 2 h / Irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol. sodium methylate 2: ethyl acetate; Raney nickel / Hydrogenation 3: 220 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanol. sodium methylate 2: Raney nickel; ethanol / Hydrogenation 3: 220 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol. sodium methylate 2: ethyl acetate; Raney nickel / Hydrogenation 3: 220 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanol. sodium methylate 2: Raney nickel; ethanol / Hydrogenation 3: 220 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydroxylamine 2: PCl5 / diethyl ether / Ambient temperature View Scheme |
2-Iodobenzoic acid
2-amino-benzenethiol
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With potassium hydroxide; copper In water |
sulfuric acid
2-(2-aminophenylthio)-benzonitrile
dibenzo[b,f][1,4]thiazepin-11-one
Conditions | Yield |
---|---|
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene; water | |
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene; water |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen / methanol / 4137.29 Torr 2: sodium carbonate 3: polyphosphoric acid / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / methanol / 4137.29 Torr 2: sodium carbonate / tetrahydrofuran; water 3: PPA / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: iron / ethanol / 1.5 h / Reflux; Large scale 1.2: 15 °C / pH 1 / Large scale 2.1: chloroform / 10 h / Reflux; Large scale 2.2: Polyphosphoric acid / 3 h / 120 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: iron; ammonium chloride / water 2: sodium carbonate / toluene 3: polyphosphoric acid / 8 h / 100 - 105 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate 2: polyphosphoric acid / Heating View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / tetrahydrofuran; water 2: PPA / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate 2: polyphosphoric acid / 80 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / toluene 2: polyphosphoric acid / 8 h / 100 - 105 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene / 0.08 h / 4 °C 1.2: 1.5 h / 4 °C 2.1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C View Scheme |
dibenzo[b,f][1,4]thiazepin-11-one
11-chloro-dibenzo[b,f][1,4]thiazepine
Conditions | Yield |
---|---|
With trichlorophosphate In toluene at 100℃; for 12h; Inert atmosphere; | 99% |
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux; | 97% |
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux; | 97% |
piperazine
titanium(IV) isopropylate
dibenzo[b,f][1,4]thiazepin-11-one
A
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
B
isopropyl alcohol
Conditions | Yield |
---|---|
at 170℃; for 5h; Heating / reflux; | A 99% B n/a |
dibenzo[b,f][1,4]thiazepin-11-one
C13H10N2S*ClH
Conditions | Yield |
---|---|
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux; | 97% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With N,N-dimethyl-aniline; trichlorophosphate In chlorobenzene at 15 - 100℃; for 3h; Stage #2: 2-[2-(1-piperazinyl)ethoxy]ethanol dihydrochloride monohydrate With sodium carbonate In dimethyl sulfoxide; chlorobenzene at 85 - 90℃; for 6 - 8h; Stage #3: (2E)-but-2-enedioic acid In ethyl acetate at 0 - 62℃; for 2.5h; Product distribution / selectivity; | 93% |
1-(2-hydroxyethyl)piperazine
titanium(IV) isopropylate
dibenzo[b,f][1,4]thiazepin-11-one
A
O-Dealkyl Quetiapine
B
isopropyl alcohol
Conditions | Yield |
---|---|
at 170℃; for 5.5h; Heating / reflux; | A 91% B n/a |
piperazine
dibenzo[b,f][1,4]thiazepin-11-one
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With trichlorophosphate In toluene at 10℃; for 4h; Heating / reflux; Stage #2: With potassium carbonate In water; toluene at 15℃; Stage #3: piperazine With hydrogenchloride more than 3 stages; | 90% |
Conditions | Yield |
---|---|
With tris(2,4-pentanedionato)ruthenium(III); ytterbium(III) trifluoromethanesulfonate nonohydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 150℃; under 3750.38 Torr; for 15h; Autoclave; | 87% |
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With hydrazine hydrate In ethylene glycol at 80℃; for 2h; Stage #2: With potassium hydroxide In water for 2h; Reflux; | 74% |
With lithium aluminium tetrahydride |
dibenzo[b,f][1,4]thiazepin-11-one
N-(p-tolyl)-2-chloroacetamide
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: N-(p-tolyl)-2-chloroacetamide In N,N-dimethyl-formamide at -5 - 30℃; | 83% |
dibenzo[b,f][1,4]thiazepin-11-one
chloro-acetic acid-(2,6-dichloro-4-nitro-anilide)
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: chloro-acetic acid-(2,6-dichloro-4-nitro-anilide) In N,N-dimethyl-formamide at -5 - 30℃; | 82% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(3-chlorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 82% |
dibenzo[b,f][1,4]thiazepin-11-one
bromoacetic acid methyl ester
(11-oxo-11H-dibenzo[b,f][1,4]thiazepin-10-yl)acetic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 60℃; for 0.166667h; Inert atmosphere; Stage #2: bromoacetic acid methyl ester In N,N-dimethyl-formamide; mineral oil at 80℃; for 5h; Inert atmosphere; | 79% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(4-fluorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 78% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(2,3-dichiorophenyl) acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 78% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: N-(4-methoxyphenyl)-2-chloroacetamide In N,N-dimethyl-formamide at -5 - 30℃; | 78% |
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(4-chlorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 76% |
dibenzo[b,f][1,4]thiazepin-11-one
4-(2-chloroacetamido)acetophenone
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 4-(2-chloroacetamido)acetophenone In N,N-dimethyl-formamide at -5 - 30℃; | 76% |
titanium(IV) isopropylate
1-[2-(2-hydroxyethoxy)ethyl]piperazine
dibenzo[b,f][1,4]thiazepin-11-one
A
isopropyl alcohol
B
quetiapine fumarate
Conditions | Yield |
---|---|
With pentan-1-ol at 160℃; for 32h; Product distribution / selectivity; Heating / reflux; | A n/a B 75% |
dibenzo[b,f][1,4]thiazepin-11-one
2-chloro-N-(3-methylphenyl)acetamide
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(3-methylphenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 74% |
dibenzo[b,f][1,4]thiazepin-11-one
2-chloro-N-(4-nitro-phenyl)-acetamide
Conditions | Yield |
---|---|
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h; Stage #2: 2-chloro-N-(4-nitro-phenyl)-acetamide In N,N-dimethyl-formamide at -5 - 30℃; | 74% |
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