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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Manufacturer/High quality/Best price/In stock

Cas:3159-07-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Dibenzo[B,F][1,4]Thiazepin-11[10H]-One supplier in China

Cas:3159-07-7

Min.Order:0 Metric Ton

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Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1180.html Product Name 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3159-07-7--10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had estab

TIANFUCHEM--3159-07-7--10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine factory price

Cas:3159-07-7

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 3159-07-7 with best quality

Cas:3159-07-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine/ LIDE PHARMA- Factory supply / Best price

Cas:3159-07-7

Min.Order:0

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Henan Sinotech Import&Export Corporation

Name: 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Other Name:Quetiapine intermediate CAS No:3159-07-7 MF: C13H9NOS Molecular weight:227.28 Grade Standard: Medicine Grade Purity: 99%min Appearance:white powder 10,11-Dihydro-11-oxodi

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS: 3159-07-7

Cas:3159-07-7

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS NO 3159-07-7

Cas:3159-07-7

Min.Order:1 Kilogram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine 3159-07-7

Cas:3159-07-7

Min.Order:1 Kilogram

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Qingdao Beluga Import and Export Co., LTD

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS:3159-07-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine CAS:3159-07-7

Cas:3159-07-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Synonyms: 11-Oxo-10,11-dihydro-Dibenzo[b,f][1,4]thiazepine;10H-DIBENZO-(1,4)-THIAZEPINE-11-ONE;10,11-DIHYDRO-11-OXODIBENZO[B,F][1,4]THIAZEPINE;DIBENZO[B,F][1,4]THIAZEPINE-11-[10H]ONE;

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Supplier best quality

Cas:3159-07-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Dibenzo[B,F][1,4]Thiazepine-11-[10H]One

Cas:3159-07-7

Min.Order:0

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Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcin

dibenzo[b,f][1,4]thiazepine-11-[10h]one

Cas:3159-07-7

Min.Order:100 Metric Ton

Negotiable

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

quetiapine fumarate intermediate 3159-07-7

Cas:3159-07-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS3159-07-7 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:0 Metric Ton

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:0

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine/High quality/Best price

Cas:3159-07-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dibenzo [b,f][1,4] Thiazepine-11-[10H] One

Cas:3159-07-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Dibenzo[b,f][1,4]Thiazepine-11-[10H]one CAS No.:3159-07-7 Molecule Formula:C13H9NOS Molecule Weight:227.28 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

Best Quality Dibenzo[b,f][1,4]Thiazepine-11-[10H]one

Cas:3159-07-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine

Cas:3159-07-7

Min.Order:1 Kilogram

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Synthetic route

2-phenylthiophenyl isocyanate
13739-55-4

2-phenylthiophenyl isocyanate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
aluminum (III) chloride In 1,2-dichloro-benzene at 100 - 150℃; for 4h;100%
phenyl [2-(phenylsulphanyl)phenyl]carbamate
111974-73-3

phenyl [2-(phenylsulphanyl)phenyl]carbamate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With methanesulfonic acid; phosphorus pentoxide at 80 - 110℃; for 2.5h;96%
With polyphosphoric acid Heating;94%
With PPA In water87%
2-((2-aminophenyl)thio)benzoic acid
54920-98-8

2-((2-aminophenyl)thio)benzoic acid

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With PPA at 140℃; for 2h;95%
toluene-4-sulfonic acid In ethyl acetate; xylene at 125℃; for 10h;86%
With phosphorus pentoxide; xylene
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-aminodiphenyl sulfide hydrochloride
6764-13-2

2-aminodiphenyl sulfide hydrochloride

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 2-aminodiphenyl sulfide hydrochloride In chloroform for 10h; Reflux; Large scale;
Stage #2: With toluene-4-sulfonic acid In chloroform at 120℃; for 3h; Large scale;
93.7%
methyl 2-(2-nitrophenylthio)[14C]benzoate
4892-03-9

methyl 2-(2-nitrophenylthio)[14C]benzoate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With acetic acid; zinc Reagent/catalyst; Reflux;93.4%
Stage #1: methyl 2-(2-nitrophenylthio)[14C]benzoate With tin(II) chloride dihdyrate In ethanol
Stage #2: With trimethylaluminum In dichloromethane at 45 - 100℃;
40%
Multi-step reaction with 2 steps
1: ethyl acetate; Raney nickel / Hydrogenation
2: 220 °C
View Scheme
Multi-step reaction with 2 steps
1: Raney nickel; ethanol / Hydrogenation
2: 220 °C
View Scheme
Multi-step reaction with 2 steps
1.1: iron(III) chloride; pyrographite / 0.5 h / 65 °C
1.2: 12 h / 65 °C
2.1: sodium methylate / toluene / 24 h / 110 °C
View Scheme
benzyl 2-(2-nitrophenylthio)benzoate

benzyl 2-(2-nitrophenylthio)benzoate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 1500.15 Torr; Reagent/catalyst;85.4%
9H-thioxanthen-9-one oxime
20169-45-3

9H-thioxanthen-9-one oxime

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Reagent/catalyst; Solvent; Reflux;81.5%
With phosphorus pentachloride In diethyl ether Ambient temperature;
2-(2-nitrophenylthio)benzoic acid methyl ester
100866-62-4

2-(2-nitrophenylthio)benzoic acid methyl ester

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With sodium methylate In toluene at 110℃; for 24h; Temperature; Reagent/catalyst;80.1%
With acetic acid at 135℃;72%
at 220℃;
2-(2-aminophenylthio)benzoic acid ethyl ester

2-(2-aminophenylthio)benzoic acid ethyl ester

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With sodium methylate In toluene at 110℃; for 24h;79.6%
carbon monoxide
201230-82-2

carbon monoxide

(2-aminophenyl)-2’-bromophenyl sulfide
63107-77-7

(2-aminophenyl)-2’-bromophenyl sulfide

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With dmap; bis(dibenzylideneacetone)-palladium(0); catacxium A In toluene at 100℃; for 18h; Sealed tube;76%
2-iodophenylamine
615-43-0

2-iodophenylamine

Methyl thiosalicylate
4892-02-8

Methyl thiosalicylate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With rongalite; sodium hydroxide In dimethyl sulfoxide at 90℃; for 48h; Inert atmosphere; Schlenk technique; Sealed tube;70%
2-phenylsulfanyl-aniline
1134-94-7

2-phenylsulfanyl-aniline

phenyl chloroformate
1885-14-9

phenyl chloroformate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With sodium carbonate In toluene62%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With copper(II) ferrite; potassium tert-butylate In N,N-dimethyl-formamide for 24h; Reflux; Inert atmosphere;60%
2-(2-trifluoroacetylaminophenylthio)benzoic acid
155882-74-9

2-(2-trifluoroacetylaminophenylthio)benzoic acid

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With trifluoroacetic anhydride In N,N-dimethyl-formamide 1.) reflux, 1 h, 2.) RT, overnight;55%
2‑(2‑nitrophenylsulfanyl)benzoic acid
19806-43-0

2‑(2‑nitrophenylsulfanyl)benzoic acid

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With tributylphosphine at 140℃; for 48h; Schlenk technique; regioselective reaction;51%
Multi-step reaction with 2 steps
1: ethyl acetate
2: triethylamine; benzotriazol-1-ol / dichloromethane
View Scheme
Multi-step reaction with 2 steps
1: hydrogen; palladium on activated charcoal / ethyl acetate / 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 12 h / 20 °C
View Scheme
2-phenyl-1,2-benzisothiazolin-3-one
2527-03-9

2-phenyl-1,2-benzisothiazolin-3-one

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
In tert-butyl alcohol for 2h; Irradiation;31%
In tert-butyl alcohol for 1.5h; Irradiation;31%
2-chloro-3-aminopyridine
6298-19-7

2-chloro-3-aminopyridine

Thiosalicylic acid
147-93-3

Thiosalicylic acid

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
In 1,2-dichloro-benzene for 0.8h; Reflux;26%
2-phenyl-1,2-benzisothiazolin-3-one
2527-03-9

2-phenyl-1,2-benzisothiazolin-3-one

A

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

B

2-phenyl-1,2-benzisothiazol-3(2H)-one 1-oxide

2-phenyl-1,2-benzisothiazol-3(2H)-one 1-oxide

Conditions
ConditionsYield
With oxygen In benzene for 2h; Product distribution; Irradiation; other solvents; without oxygen.;A 15%
B 8%
With N-chloro-succinimide; potassium hydrogencarbonate 1) CH2Cl2, 0 deg C, 20 min; 2) water, 1 h.; Yield given. Multistep reaction;
carbon dioxide
124-38-9

carbon dioxide

2-phenylsulfanyl-aniline
1134-94-7

2-phenylsulfanyl-aniline

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With n-butyllithium 1) ether, room temperature, 30 h, 2) ether; Yield given. Multistep reaction;
2-(2-aminophenylthio)benzoic acid hydrochloride

2-(2-aminophenylthio)benzoic acid hydrochloride

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dioxane / 18 h / Ambient temperature
2: 55 percent / trifluoroacetic anhydride / dimethylformamide / 1.) reflux, 1 h, 2.) RT, overnight
View Scheme
2,2'-dithiodibenzoic acid dichloride
19602-82-5

2,2'-dithiodibenzoic acid dichloride

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2) bromine; 3) basic alumina
2: 31 percent / 2-methyl-propan-2-ol / 2 h / Irradiation
View Scheme
aniline
62-53-3

aniline

ethane-α.β-bis-sulfonic acid chloride

ethane-α.β-bis-sulfonic acid chloride

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2) bromine; 3) basic alumina
2: 31 percent / 2-methyl-propan-2-ol / 2 h / Irradiation
View Scheme
2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol. sodium methylate
2: ethyl acetate; Raney nickel / Hydrogenation
3: 220 °C
View Scheme
Multi-step reaction with 3 steps
1: methanol. sodium methylate
2: Raney nickel; ethanol / Hydrogenation
3: 220 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / dimethyl sulfoxide / 80 °C
2: hydrogen / methanol / 4137.29 Torr
3: sodium carbonate / tetrahydrofuran; water
4: PPA / 100 °C
View Scheme
Methyl thiosalicylate
4892-02-8

Methyl thiosalicylate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol. sodium methylate
2: ethyl acetate; Raney nickel / Hydrogenation
3: 220 °C
View Scheme
Multi-step reaction with 3 steps
1: methanol. sodium methylate
2: Raney nickel; ethanol / Hydrogenation
3: 220 °C
View Scheme
thioxanthene-9-thione
3591-73-9

thioxanthene-9-thione

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine
2: PCl5 / diethyl ether / Ambient temperature
View Scheme
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With potassium hydroxide; copper In water
sulfuric acid
7664-93-9

sulfuric acid

2-(2-aminophenylthio)-benzonitrile
140425-65-6

2-(2-aminophenylthio)-benzonitrile

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene; water
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene; water
2-nitrophenyl phenyl sulfide
4171-83-9

2-nitrophenyl phenyl sulfide

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen / methanol / 4137.29 Torr
2: sodium carbonate
3: polyphosphoric acid / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogen / methanol / 4137.29 Torr
2: sodium carbonate / tetrahydrofuran; water
3: PPA / 100 °C
View Scheme
Multi-step reaction with 2 steps
1.1: iron / ethanol / 1.5 h / Reflux; Large scale
1.2: 15 °C / pH 1 / Large scale
2.1: chloroform / 10 h / Reflux; Large scale
2.2: Polyphosphoric acid / 3 h / 120 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: iron; ammonium chloride / water
2: sodium carbonate / toluene
3: polyphosphoric acid / 8 h / 100 - 105 °C
View Scheme
2-phenylsulfanyl-aniline
1134-94-7

2-phenylsulfanyl-aniline

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate
2: polyphosphoric acid / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate / tetrahydrofuran; water
2: PPA / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate
2: polyphosphoric acid / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate / toluene
2: polyphosphoric acid / 8 h / 100 - 105 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene / 0.08 h / 4 °C
1.2: 1.5 h / 4 °C
2.1: methanesulfonic acid; phosphorus pentoxide / 2.5 h / 80 - 110 °C
View Scheme
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

11-chloro-dibenzo[b,f][1,4]thiazepine
13745-86-3

11-chloro-dibenzo[b,f][1,4]thiazepine

Conditions
ConditionsYield
With trichlorophosphate In toluene at 100℃; for 12h; Inert atmosphere;99%
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux;97%
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux;97%
piperazine
110-85-0

piperazine

titanium(IV) isopropylate
546-68-9

titanium(IV) isopropylate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

A

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
5747-48-8

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine

B

isopropyl alcohol
67-63-0

isopropyl alcohol

Conditions
ConditionsYield
at 170℃; for 5h; Heating / reflux;A 99%
B n/a
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

C13H10N2S*ClH
1176987-11-3

C13H10N2S*ClH

Conditions
ConditionsYield
With N,N-dimethyl-aniline; trichlorophosphate at 106℃; for 6h; Heating / reflux;97%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-[2-(1-piperazinyl)ethoxy]ethanol dihydrochloride monohydrate

2-[2-(1-piperazinyl)ethoxy]ethanol dihydrochloride monohydrate

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine hemifumarate salt

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With N,N-dimethyl-aniline; trichlorophosphate In chlorobenzene at 15 - 100℃; for 3h;
Stage #2: 2-[2-(1-piperazinyl)ethoxy]ethanol dihydrochloride monohydrate With sodium carbonate In dimethyl sulfoxide; chlorobenzene at 85 - 90℃; for 6 - 8h;
Stage #3: (2E)-but-2-enedioic acid In ethyl acetate at 0 - 62℃; for 2.5h; Product distribution / selectivity;
93%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

titanium(IV) isopropylate
546-68-9

titanium(IV) isopropylate

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

A

O-Dealkyl Quetiapine
329216-67-3

O-Dealkyl Quetiapine

B

isopropyl alcohol
67-63-0

isopropyl alcohol

Conditions
ConditionsYield
at 170℃; for 5.5h; Heating / reflux;A 91%
B n/a
piperazine
110-85-0

piperazine

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride
753475-15-9

11-piperazin-1-yldibenzo[b,f][1,4]thiazepine hydrochloride

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With trichlorophosphate In toluene at 10℃; for 4h; Heating / reflux;
Stage #2: With potassium carbonate In water; toluene at 15℃;
Stage #3: piperazine With hydrogenchloride more than 3 stages;
90%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

10,11-Dihydrodibenz[b,f][1,4]thiazepine
494-20-2

10,11-Dihydrodibenz[b,f][1,4]thiazepine

Conditions
ConditionsYield
With tris(2,4-pentanedionato)ruthenium(III); ytterbium(III) trifluoromethanesulfonate nonohydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 150℃; under 3750.38 Torr; for 15h; Autoclave;87%
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With hydrazine hydrate In ethylene glycol at 80℃; for 2h;
Stage #2: With potassium hydroxide In water for 2h; Reflux;
74%
With lithium aluminium tetrahydride
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

N-(p-tolyl)-2-chloroacetamide
16634-82-5

N-(p-tolyl)-2-chloroacetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-methylphenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-methylphenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: N-(p-tolyl)-2-chloroacetamide In N,N-dimethyl-formamide at -5 - 30℃;
83%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

chloro-acetic acid-(2,6-dichloro-4-nitro-anilide)
138681-35-3

chloro-acetic acid-(2,6-dichloro-4-nitro-anilide)

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(2,6-dichloro-4-nitrophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(2,6-dichloro-4-nitrophenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: chloro-acetic acid-(2,6-dichloro-4-nitro-anilide) In N,N-dimethyl-formamide at -5 - 30℃;
82%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(3-chlorophenyl)acetamide
2564-05-8

2-chloro-N-(3-chlorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(3-chlorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(3-chlorophenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(3-chlorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃;
82%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

(11-oxo-11H-dibenzo[b,f][1,4]thiazepin-10-yl)acetic acid methyl ester
1073181-74-4

(11-oxo-11H-dibenzo[b,f][1,4]thiazepin-10-yl)acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 60℃; for 0.166667h; Inert atmosphere;
Stage #2: bromoacetic acid methyl ester In N,N-dimethyl-formamide; mineral oil at 80℃; for 5h; Inert atmosphere;
79%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(4-fluorophenyl)acetamide
351-04-2

2-chloro-N-(4-fluorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-fluorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-fluorophenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(4-fluorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃;
78%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(2,3-dichiorophenyl) acetamide
33560-47-3

2-chloro-N-(2,3-dichiorophenyl) acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(2,3-dichiorophenyl) acetamide In N,N-dimethyl-formamide at -5 - 30℃;
78%

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-methoxyphenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-methoxyphenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: N-(4-methoxyphenyl)-2-chloroacetamide In N,N-dimethyl-formamide at -5 - 30℃;
78%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(4-chlorophenyl)acetamide
3289-75-6

2-chloro-N-(4-chlorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-chlorophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-chlorophenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(4-chlorophenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃;
76%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

4-(2-chloroacetamido)acetophenone
38283-38-4

4-(2-chloroacetamido)acetophenone

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-acetylphenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-acetylphenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 4-(2-chloroacetamido)acetophenone In N,N-dimethyl-formamide at -5 - 30℃;
76%
titanium(IV) isopropylate
546-68-9

titanium(IV) isopropylate

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

A

isopropyl alcohol
67-63-0

isopropyl alcohol

B

quetiapine fumarate
111974-72-2

quetiapine fumarate

Conditions
ConditionsYield
With pentan-1-ol at 160℃; for 32h; Product distribution / selectivity; Heating / reflux;A n/a
B 75%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(3-methylphenyl)acetamide
32428-61-8

2-chloro-N-(3-methylphenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(3-methylphenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(3-methylphenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(3-methylphenyl)acetamide In N,N-dimethyl-formamide at -5 - 30℃;
74%
dibenzo[b,f][1,4]thiazepin-11-one
3159-07-7

dibenzo[b,f][1,4]thiazepin-11-one

2-chloro-N-(4-nitro-phenyl)-acetamide
17329-87-2

2-chloro-N-(4-nitro-phenyl)-acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-nitrophenyl)acetamide

2-(11-oxodibenzo[b,f][1,4]thiazepin-10(11H)-yl)-N-(4-nitrophenyl)acetamide

Conditions
ConditionsYield
Stage #1: dibenzo[b,f][1,4]thiazepin-11-one With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.916667h;
Stage #2: 2-chloro-N-(4-nitro-phenyl)-acetamide In N,N-dimethyl-formamide at -5 - 30℃;
74%

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