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Hebei Nengqian Chemical Import and Export Co., LTD

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents, Our company h

2-IODOBENZOIC ACID METHYL ESTER CAS 610-97-9

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Jinon Pharma (Wuhan) Co., Ltd.

Product name: Methyl 2-iodobenzoate Alias: 2-iodobenzoic acid methyl ester CAS: 610-97-9 Molecular formula: C8H7IO2 Chemical structure: Methyl 2-iodobenzoate Appearance: colorless to light red liquid Content: 98% above Uses: me

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl 2-Iodobenzoate supplier in China

Cas:610-97-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

1 high purity 2 able to provide COA/HNMR/HPLC 3 High quality 4 low price 5 Best service Appearance:white crystalline powder Storage:-20°C Package:bag/bottle/drum Application:pharmaceutical intermediate Transportation:common transportation Por

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Methyl 2-iodobenzoate CAS number 610-97-9 Assay ≥99% Appearance Colorless to yellowish liquid Capacity 200mt/year Application Pharmaceutical

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply Methyl 2-iodobenzoate Cas 610-97-9 with low price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed addi

Factory supply Methyl 2-iodobenzoate Cas 610-97-9 with low price

Cas:610-97-9

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 610-97-9 Methyl 2-iodobenzoate Manufacturer

Cas:610-97-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Iodobenzoic acid methyl ester

Cas:610-97-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

610-97-9 Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 610-97-9 with best quality

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name: Methyl 2-iodobenzoate CAS No.: 610-97-9 Molecular formula C8H7IO2 Appearance: Colorless to slight red liquid Assay: 98.0% S

Methyl 2-iodobenzoate CAS:610-97-9

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoicacid, 2-iodo-, methyl ester 610-97-9

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediates, Methyl 2-iodobenzoate CAS:610-97-9

Cas:610-97-9

Min.Order:1 Kilogram

FOB Price: $50.0 / 56.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Methyl 2-iodobenzoate CAS:610-97-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

Methyl 2-iodobenzoate CAS:610-97-9

Cas:610-97-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Kemi-Works Chemical Co., Ltd

ISO9001 1.Appearance: Colorless to redish 2.CAS No.610-97-9 3.MF: C8H7IO2 4.Assay: 98% min Appearance:colorless to redish liquid Storage:Store in dry and cool place with good seal Package:25kg/ Plastic drum Application:Pharmaceutical Intermedi

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:10 Gram

Negotiable

Type:Other

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Methyl 2-iodobenzoate CAS 610-97-9

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:610-97-9

Cas:610-97-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Methyl 2-Iodobenzoate

Cas:610-97-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

METHYL 2-IODOBENZOATE

Cas:610-97-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:100 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colourless or light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharm

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Methyl 2-iodobenzoate

Cas:610-97-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methanol
67-56-1

methanol

2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With sulfuric acid Reflux;100%
With sulfuric acid for 3h; Reflux;99%
With sulfuric acid at 80℃; for 2.5h; Inert atmosphere;99%
methanol
67-56-1

methanol

2-Iodobenzoyl chloride
609-67-6

2-Iodobenzoyl chloride

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With sulfuric acid Reflux;98%
With sodium hydroxide
With oxalyl dichloride In dichloromethane for 0.5h; Inert atmosphere;
With triethylamine at 0 - 20℃; for 2h;
With triethylamine at 0 - 20℃; for 0.5h;0.42 g
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

methyl iodide
74-88-4

methyl iodide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With potassium carbonate In acetone98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;96%
Stage #1: 2-Iodobenzoic acid With caesium carbonate In N,N-dimethyl-formamide
Stage #2: methyl iodide In N,N-dimethyl-formamide at 50℃; for 1h;
95%
2-(methoxycarbonyl)phenylzinc iodide
693232-15-4

2-(methoxycarbonyl)phenylzinc iodide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With N-chloro-succinimide In various solvent(s) at 20℃; for 0.166667h; Substitution;96%
With N-chloro-succinimide In various solvent(s) at 20℃; for 0.166667h;48%
trifluoroacetic acid-methyl ester
431-47-0

trifluoroacetic acid-methyl ester

1-(2-iodophenyl)pentan-1-one
32730-83-9

1-(2-iodophenyl)pentan-1-one

A

1,1,1-trifluoro-2-hexanone
360-34-9

1,1,1-trifluoro-2-hexanone

B

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Stage #1: trifluoroacetic acid-methyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: 1-(2-iodophenyl)pentan-1-one In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere; Schlenk technique;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0℃; for 0.25h; Inert atmosphere; Schlenk technique;
A n/a
B 96%
2-carbomethoxyaniline
134-20-3

2-carbomethoxyaniline

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Stage #1: 2-carbomethoxyaniline With sulfuric acid; sodium nitrite In water at 0 - 7℃; Inert atmosphere;
Stage #2: With sulfuric acid; sodium hydrogensulfite; potassium iodide In water at -5 - 80℃; for 1.58333h; Inert atmosphere;
93%
Stage #1: 2-carbomethoxyaniline With sulfuric acid; sodium nitrite
Stage #2: With potassium iodide
Stage #1: 2-carbomethoxyaniline With toluene-4-sulfonic acid In acetonitrile at 20℃; for 0.166667h;
Stage #2: With potassium iodide; sodium nitrite In water; acetonitrile at 0 - 20℃;
2-iodo-N-(quinolin-8-yl)benzamide
723259-89-0

2-iodo-N-(quinolin-8-yl)benzamide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 110℃; for 36h; Sealed tube;93%
benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Stage #1: benzoic acid methyl ester With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; cadmium(II) chloride-N,N,N',N'-tetramethylethylenediamine In tetrahydrofuran; hexane at 0 - 20℃; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; hexane Inert atmosphere; chemoselective reaction;
89%
Stage #1: benzoic acid methyl ester With (2,2,6,6-tetramethylpiperidido)2Ag(CN)Li2 In tetrahydrofuran at -40℃; for 2h;
Stage #2: With iodine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; chemoselective reaction;
86%
With N-iodo-succinimide; silver hexafluoroantimonate; trifluorormethanesulfonic acid; nickel diacetate In 1,2-dichloro-ethane at 80℃; for 12h; regioselective reaction;77%
Stage #1: benzoic acid methyl ester With cadmium(II) chloride-N,N,N',N'-tetramethylethylenediamine; 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; hexane Inert atmosphere; regioselective reaction;
62%
With 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; di-tert-butylzinc 1.) THF, RT, 2.) THF, RT; Yield given; Multistep reaction;
boron trifluoride dimethyl etherate
353-42-4

boron trifluoride dimethyl etherate

2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
at 120℃; for 4h; Reflux;89%
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 16h; Inert atmosphere; Green chemistry;88%
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate at 90℃; Schlenk technique;85%
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

methyl 1-imidazolecarboxylate
61985-23-7

methyl 1-imidazolecarboxylate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere;84%
Monomethyl phthalate
4376-18-5

Monomethyl phthalate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione In 1,2-dichloro-ethane for 24h; Irradiation; Inert atmosphere; Reflux;80%
With N-iodo-succinimide; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; iodine; caesium carbonate In 1,2-dichloro-ethane at 50℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;65%
2-iodo-N-methoxybenzamide
1225463-02-4

2-iodo-N-methoxybenzamide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With N-Bromosuccinimide In toluene at 60℃; for 1h;76%
methyl 2-(tosyldiazenyl)benzoate
105230-44-2

methyl 2-(tosyldiazenyl)benzoate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With 18-crown-6 ether; potassium iodide In diethyl ether; acetonitrile for 4h; Ambient temperature;74%
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

[bis(acetoxy)iodo]benzene
3240-34-4

[bis(acetoxy)iodo]benzene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With copper diacetate; acetic anhydride In N,N-dimethyl-formamide; acetonitrile at 130℃; for 1h; Sealed tube;57%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

1-(2-iodophenyl)diazonium tetrafluoroborate
7169-58-6

1-(2-iodophenyl)diazonium tetrafluoroborate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With fluorescein free acid In acetonitrile at 20℃; under 60804.1 Torr; for 21h; Autoclave; Irradiation;50%
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; methanol
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere
2: oxalyl dichloride / dichloromethane / 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / benzene / 2 h / 80 °C
2: triethylamine / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h
2: triethylamine / 0.5 h / 0 - 20 °C
View Scheme
2-dichloroiodanyl-benzoic acid methyl ester
828-76-2

2-dichloroiodanyl-benzoic acid methyl ester

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With (dissociation) In acetic acid at 15℃; Rate constant;
anthranilic acid
118-92-3

anthranilic acid

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C / Inert atmosphere
1.2: 1 h / 10 - 90 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere
3.1: oxalyl dichloride / dichloromethane / 0.5 h / Inert atmosphere
View Scheme
N-quinolin-8-yl-benzamide
33757-48-1

N-quinolin-8-yl-benzamide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: nickel dichloride; ammonium thiocyanate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 120 °C
1.2: -10 °C
2.1: toluene-4-sulfonic acid / methanol / 36 h / 110 °C / Sealed tube
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; triethylamine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 - 20 °C / Inert atmosphere
2.1: nickel dichloride; ammonium thiocyanate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 120 °C
2.2: -10 °C
3.1: toluene-4-sulfonic acid / methanol / 36 h / 110 °C / Sealed tube
View Scheme
2-bromobenzoic acid methyl ester
610-94-6

2-bromobenzoic acid methyl ester

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With copper(l) iodide; sodium iodide; zinc(II) iodide; N,N`-dimethylethylenediamine In 1,4-dioxane at 120℃; under 1500.15 Torr; for 24h; Reagent/catalyst; Finkelstein Reaction; Autoclave; Inert atmosphere; Schlenk technique;
methyl 2-{[(4-methylphenyl)sulfonyl]oxy}benzoate
51207-44-4

methyl 2-{[(4-methylphenyl)sulfonyl]oxy}benzoate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (1,2-dimethoxyethane)dichloronickel(II); 1,4-bis(2,6-diisopropylphenyl)-2,3-dimethyl-1,4-diazabuta-1,3-diene / N,N-dimethyl-formamide; ethylene dibromide / 20 h / 20 °C / Schlenk technique
2: iodine / 0.17 h / 0 °C
View Scheme
C15H14O5SZn

C15H14O5SZn

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Conditions
ConditionsYield
With iodine at 0℃; for 0.166667h;501 mg
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

ethyl 4-(iodozincio)butanoate
104089-17-0

ethyl 4-(iodozincio)butanoate

ethyl 4-[(2-methoxycarbonyl)phenyl]butanoate
105986-53-6

ethyl 4-[(2-methoxycarbonyl)phenyl]butanoate

Conditions
ConditionsYield
dichlorobis(tri-O-tolylphosphine)palladium In N,N-dimethyl acetamide; benzene at 60℃; for 0.5h;100%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

propargyl alcohol
107-19-7

propargyl alcohol

methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate
103606-72-0

methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 40℃; for 0.5h; Sonogashira Cross-Coupling; Microwave irradiation;100%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In acetonitrile for 3h; Inert atmosphere; Reflux;92%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammomium bromide; triethylamine In benzene at 60℃; for 0.5h;90%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

phenylacetylene
536-74-3

phenylacetylene

methyl 2-(phenylethynyl)benzoate
33578-05-1

methyl 2-(phenylethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Sonogashira Cross-Coupling; Inert atmosphere;100%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 55℃; Sonogashira coupling;99%
With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine In tetrahydrofuran at 55℃; Inert atmosphere;99%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate
107793-07-7

methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate

Conditions
ConditionsYield
With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; Sonogashira coupling reaction;100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 15h; Sonogashira coupling; Inert atmosphere;100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 24h; Inert atmosphere;100%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

methyl 4'-methoxybiphenyl-2-carboxylate
17103-25-2

methyl 4'-methoxybiphenyl-2-carboxylate

Conditions
ConditionsYield
With palladium diacetate; sodium carbonate In water; acetonitrile at 60℃; Suzuki-Miyaura Coupling; Inert atmosphere;100%
With bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate In tetrahydrofuran; water at 80℃; for 14h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; Sealed tube;95%
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In toluene for 18h; Heating;80%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

2-(1-Hydroxypropyl)-1-ethynylbenzene
166757-15-9

2-(1-Hydroxypropyl)-1-ethynylbenzene

Methyl 2-<2-<2-(1-hydroxy-1-propyl)phenyl>ethynyl>benzoate
166757-17-1

Methyl 2-<2-<2-(1-hydroxy-1-propyl)phenyl>ethynyl>benzoate

Conditions
ConditionsYield
With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine for 16h; Heating;100%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

2'-methoxy-biphenyl-2-carboxylic acid methyl ester
63506-58-1

2'-methoxy-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With palladium diacetate; sodium carbonate; triphenylphosphine In water; N,N-dimethyl-formamide for 18h; Suzuki coupling; Ionic liquid; Reflux; Inert atmosphere;100%
With potassium phosphate; SBA-Si-PEG-Pd(PPh3)n In water at 50℃; for 10h; Suzuki coupling;89%
With di-tert-butylphosphine; (2,6-iPr2-C6H3OCO-N)-imidazolium-(N-CH2C6H4-2-Br) bromide; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 150℃; for 48h; Suzuki-Miyaura coupling;86%
With potassium carbonate In water at 80℃; for 10h; Suzuki-Miyaura Coupling; Green chemistry;26%
carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

cyclohexylamine
108-91-8

cyclohexylamine

N-cyclohexylphthalimide
2133-65-5

N-cyclohexylphthalimide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium 10% on activated carbon In toluene at 120℃; under 4654.46 Torr; for 2h; Autoclave;93%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; caesium carbonate In toluene at 95℃; for 24h;92%
carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

benzylamine
100-46-9

benzylamine

N-benzylphthalimide
2142-01-0

N-benzylphthalimide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; caesium carbonate In toluene at 95℃; for 24h; Reactivity; Reagent/catalyst; Concentration; Solvent; Temperature; Time;91%
With triethylamine In toluene at 100℃;80%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

dimethyl (1,1'-biphenyl)-2,3'-dicarboxylate
32947-58-3

dimethyl (1,1'-biphenyl)-2,3'-dicarboxylate

Conditions
ConditionsYield
With norborn-2-ene; palladium diacetate; caesium carbonate; triphenylphosphine In 1,2-dimethoxyethane at 90℃; for 1.5h; Sealed vial;100%
With norbornene; palladium/alumina; potassium carbonate; benzyl alcohol at 105℃; for 72h;80%
Cyclopropylacetylene
6746-94-7

Cyclopropylacetylene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-(cyclopropylethynyl)benzoate

methyl 2-(cyclopropylethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine at 20℃; Sonogashira coupling;100%
Stage #1: Cyclopropylacetylene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 20h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine99%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

4-n-methylphenylacetylene
766-97-2

4-n-methylphenylacetylene

methyl 2-[(4-methylphenyl)ethynyl]benzoate
118520-72-2

methyl 2-[(4-methylphenyl)ethynyl]benzoate

Conditions
ConditionsYield
Stage #1: o-iodo-methyl-benzoic acid; 4-n-methylphenylacetylene With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
Stage #1: o-iodo-methyl-benzoic acid With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran for 0.0833333h;
Stage #2: 4-n-methylphenylacetylene In tetrahydrofuran for 16h; Reflux;
99%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Sonogashira coupling; Inert atmosphere;95%
carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

N-butylamine
109-73-9

N-butylamine

N-butylphthalimide
1515-72-6

N-butylphthalimide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
With triethylamine In toluene at 100℃;79%
4-n-chlorophenylacetylene
873-73-4

4-n-chlorophenylacetylene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester
118520-71-1

2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-n-chlorophenylacetylene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 2h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
Stage #1: 4-n-chlorophenylacetylene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.166667h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 1h; Sonogashira Cross-Coupling; Inert atmosphere;
99%
Sonogashira Cross-Coupling;
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

2-ethynyl-benzoic acid methyl ester
33577-99-0

2-ethynyl-benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: o-iodo-methyl-benzoic acid; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
Stage #2: With potassium carbonate In tetrahydrofuran; methanol at 20℃; for 12h; Inert atmosphere;
100%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

4-tert-butylphenylboronic acid
123324-71-0

4-tert-butylphenylboronic acid

methyl 4′-(tert butyl)-[1,1′-biphenyl]-2-carboxylate
1528793-37-4

methyl 4′-(tert butyl)-[1,1′-biphenyl]-2-carboxylate

Conditions
ConditionsYield
With bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate In tetrahydrofuran; water at 80℃; for 14h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; Sealed tube;100%
With palladium diacetate; sodium carbonate In water; acetonitrile at 60℃; Suzuki-Miyaura Coupling; Inert atmosphere;90%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water at 20 - 80℃; Suzuki Coupling; Schlenk technique; Inert atmosphere;
With potassium phosphate; palladium diacetate; triphenylphosphine In toluene at 80℃; Inert atmosphere; Schlenk technique;
tetraacetyl thioglucose
19879-84-6

tetraacetyl thioglucose

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-((2-(methoxycarbonyl)phenyl)thio)tetrahydro-2H-pyran-3,4,5-triyl triacetate
112023-27-5

(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-((2-(methoxycarbonyl)phenyl)thio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; Schlenk technique; Sealed tube;100%
3-ethynylthiophene
67237-53-0

3-ethynylthiophene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-[2-(thiophen-3-yl)ethynyl]benzoate

methyl 2-[2-(thiophen-3-yl)ethynyl]benzoate

Conditions
ConditionsYield
Stage #1: 3-ethynylthiophene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 3h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
Stage #1: o-iodo-methyl-benzoic acid With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 1h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: 3-ethynylthiophene In N,N-dimethyl-formamide at 80 - 85℃; for 15h; Sonogashira Cross-Coupling; Inert atmosphere;
82%
With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine In acetonitrile for 18h; Inert atmosphere; Schlenk technique;78%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 85℃; for 16h; Sonogashira Cross-Coupling; Inert atmosphere;
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Sonogashira Cross-Coupling; Inert atmosphere;
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

3-methoxyphenylboronic acid
10365-98-7

3-methoxyphenylboronic acid

3'-methoxy-[1,1'-biphenyl]-2-carboxylic acid
38087-96-6

3'-methoxy-[1,1'-biphenyl]-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: o-iodo-methyl-benzoic acid; 3-methoxyphenylboronic acid With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate In 1,2-dimethoxyethane; water at 180℃; for 0.25h; Microwave irradiation;
Stage #2: With sodium hydroxide In methanol; water at 150℃; for 0.0833333h; Microwave irradiation;
100%
1-ethynyl-3-trifluoromethylbenzene
705-28-2

1-ethynyl-3-trifluoromethylbenzene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-((3-(trifluoromethyl)phenyl)ethynyl)benzoate

methyl 2-((3-(trifluoromethyl)phenyl)ethynyl)benzoate

Conditions
ConditionsYield
Stage #1: 1-ethynyl-3-trifluoromethylbenzene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
Stage #1: 1-ethynyl-3-trifluoromethylbenzene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.166667h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere;
77%
hexan-1-amine
111-26-2

hexan-1-amine

carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

N-hexylphthalimide
20320-48-3

N-hexylphthalimide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

4-Aminoacetophenone
99-92-3

4-Aminoacetophenone

2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione
40101-59-5

2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
propylamine
107-10-8

propylamine

carbon monoxide
201230-82-2

carbon monoxide

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

N-propylphthalimide
5323-50-2

N-propylphthalimide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
cyclopentylacetylene
930-51-8

cyclopentylacetylene

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-(cyclopentylethynyl)benzoate

methyl 2-(cyclopentylethynyl)benzoate

Conditions
ConditionsYield
Stage #1: cyclopentylacetylene; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; triethylamine at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide at 50℃; for 20h; Sonogashira Cross-Coupling; Inert atmosphere;
100%
1-Pentyne
627-19-0

1-Pentyne

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-(pent-1-yn-1-yl)benzoate
90584-93-3

methyl 2-(pent-1-yn-1-yl)benzoate

Conditions
ConditionsYield
With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 20℃; for 24h; Arylation;99%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Condensation;99%
With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; for 24h; Sonogashira coupling reaction;98%
pent-1-yn-5-ol
5390-04-5

pent-1-yn-5-ol

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

2-(5-hydroxypent-1-ynyl)benzoic acid methyl ester
152771-70-5

2-(5-hydroxypent-1-ynyl)benzoic acid methyl ester

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 15h; Sonogashira Cross-Coupling; Inert atmosphere;99%
With copper(l) iodide; triethylamine; trans-bis(triphenylphosphine)palladium(II) chloride at 25℃; for 12h;92%
With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) Sonogashira coupling reaction;86%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 55℃; Sonogashira coupling;85%
Stage #1: o-iodo-methyl-benzoic acid With triethylamine for 0.0833333h; Inert atmosphere;
Stage #2: pent-1-yn-5-ol With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 20℃; for 7h; Sonogashira coupling; Inert atmosphere;
84%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

hex-1-yne
693-02-7

hex-1-yne

2-(1-hexynyl)benzoic acid methyl ester
462637-40-7

2-(1-hexynyl)benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: o-iodo-methyl-benzoic acid With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; triphenylphosphine at 20℃; for 1h; Inert atmosphere;
Stage #2: hex-1-yne at 0 - 20℃; Inert atmosphere;
99%
Stage #1: hex-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: o-iodo-methyl-benzoic acid In N,N-dimethyl-formamide at 25℃; for 2h; Inert atmosphere; Schlenk technique;
98%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h;96%
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

N-Boc-indole-2-boronic acid
213318-44-6

N-Boc-indole-2-boronic acid

methyl 2-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]benzoate
1095343-62-6

methyl 2-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]benzoate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water for 12h; Suzuki-Miyaura coupling; Inert atmosphere; Reflux;99%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water for 12h; Suzuki coupling; Reflux;97%
2,2-dimethyl-3-butyne
917-92-0

2,2-dimethyl-3-butyne

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

methyl 2-(3,3-dimethylbut-1-yn-1-yl)benzoate
934701-48-1

methyl 2-(3,3-dimethylbut-1-yn-1-yl)benzoate

Conditions
ConditionsYield
Stage #1: 3,3-Dimethylbut-1-yne; o-iodo-methyl-benzoic acid With trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With copper(l) iodide In N,N-dimethyl-formamide at 50℃; for 16h; Sonogashira Cross-Coupling; Inert atmosphere;
99%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-butylamine In diethyl ether Sonogashira coupling;98%
Stage #1: 3,3-Dimethylbut-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: o-iodo-methyl-benzoic acid In N,N-dimethyl-formamide at 25℃; for 2h; Inert atmosphere; Schlenk technique;
91%

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