The anticoagulant and estrogenic effects of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17β-yl)-6-hydroxyhexylamine, are described. A single subcutaneous injection of hexolame in adult and infant male mice produced dose-dependent increases in blood clotting time which could be observed even aft...

BackgroundUsing anti_mullerian hormone (AMH) for Polycystic Ovary Syndrome diagnosis is not always constant. Thyroid dysfunction may effect on AMH levels.

Orange carotenoid protein (OCP) is a cyanobacterial photoactive protein which binds echinenone as a chromophore; it is involved in photoprotection of these photosynthetic organisms against intense illumination. In its resting state, OCP appears orange (OCPo), and turns into a red form (OCPr) whe...

Orange peel waste (OPW) can be an effective feedstock for extraction of natural bioactive components such as limonene, a high value-added chemical broadly exploited for food, pharmaceutical, and cosmetic industrial applications. Extraction of limonene from OPW has been conventionally performed v...

In A. rhizogenes, various Ri plasmids are found that show some differences in terms of genetic organization as compared to the reference plasmid pRiA4. On this plasmid as well on the pRi2659 and pRi8196, the T-DNA genes rolA, rolB, and rolC (ORFs10, 11, and 12) appear to sufice to induce root fo...

A new opine, cucumopine, has been identified by high voltage paper electrophoresis in hairy roots induced by Agrobacterium rhizogenes. Cucumopine gives a positive reaction with the Pauly imidazole reagent, the phenanthrene quinone reagent and alkaline silver nitrate. This substance was also foun...

A concise synthesis of the β-lactone esterase inhibitor valilactone (1) is reported. This synthesis employs the stereoselctive preparation of a π-allyltricarbonyliron lactone complex (7) that on oxidation with ceric ammonium nitrate, affords an appropriately substituted β-lactone (9) which wa...

Synthesis of the esterase inhibitor valilactone (1) is reported employing the oxidation of π-allyltricarbonyliron lactone complexes with ceric ammonium nitrate to afford the inherent β-lactone ring.

The highly diastereoselective aldol reaction between acyl complexes of the iron chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] and β-hydroxy aldehydes (obtained via a Noyori asymmetric hydrogenation), followed by a tandem oxidative decomplexation–cyclisation process gives access to β-substituted a...

Bromobenzene (300 mg./k.) was administered to three human subjects over a period of two days. No untoward toxic effects were observed. Mercapturic acid could not be isolated from the urine by chloroform extraction. Isotope dilution and iodine titration analyses indicated that very little, if any...

CTP:phosphocholine cytidylyltransferase (CT), the rate controlling enzyme in phosphatidylcholine biosynthesis, is activated by reversible membrane binding. To investigate the membrane binding mechanism of CT, we have used the photoreactive hydrophobic probe 3-(trifluoromethyl)-3-(m-[125I]iodophe...

ObjectiveAlthough the anticoagulatory properties of hirudin are well known, its direct vasoactive effects have not been investigated extensively. Hirudin stimulates nitric oxide and prostacyclin production in noncoronary vascular beds, but its actions on coronary arteries are unknown.

A new iridoid glucoside, sesamoside, isolated from Sesamum angolense (Pedaliaceae), has been assigned the structure methyl antirrinoside-4-carboxylate. It was accompanied by the known iridoid glucosides phlomiol, pulchelloside-I and 6β-hydroxyipolamiide, and by the phenylpropanoid glycoside ver...

Six nitrile glucosides and one cyanogenic glucoside (epiheterodendrin) have been isolated from the leaves of members of the Rosaceae-Prunoideae and Rosaceae-Kerrieae. Two of these, 4-β-d-glucopyranosyloxy-2R,3R-epoxy-3-hydroxymethyl-butyronitrile (sutherlandin epoxide) and 4-β-d-glucopyranosyl...

Protected forms of (2S,3S)-2,3-bis(hydroxymethyl)cyclobutanone, key intermediates for the synthesis of chiral carbocyclic oxetanocin analogues, were prepared from Feist's acid.

A short (5-step) synthesis of the oxetanocin A analogues 12a and 12b has been accomplished, with very good stereoselectivity in the key iodocyclization step.

A series of phosphonoalkyl derivatives of antiviral antibiotics oxetanocin-A 2 were synthesized and tested in vitro for anti-HSV-1, HSV-2, and anti-HIV-1 activity.

Carbocyclic oxetanocin analogues containing 3-fluoro or 3-hydroxy cyclobutyl moieties and different natural bases, have been prepared from the olefinic precursors either by direct fluoro-iodination (AgF-I2) or by DAST fluorination of the bromhydrin. The latter allowed the synthesis of the corres...

SummaryOxetanocin G(9-(2-deoxy-2-hydroxymethyl-β-D-erythro-oxetanosyl)guanine, OXTG) is a potent and selective agent against human cytomegalovirus (HCMV). In this study we synthesized the triphosphate form of OXT-G, OXT-GTP, and examined its effect on the activities of HCMV DNA polymerase, herp...

EPR and optical absorption studies have been carried out on Cu(3-methyl, 5-phenyl isoxazole) Br2 and Cu(3,5-dimethyl isoxazole)Br2 in N,N-dimethylformamide (DMF) and pyridine in order to study the solvent effects on these complexes. The EPR spectrum of the former complex in pyridine at room temp...