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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Riluzole Powder CAS 1744-22-5 Best Price

Cas:1744-22-5

Min.Order:1 Kilogram

FOB Price: $6.5 / 7.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Riluzole

Cas:1744-22-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

1. Usage of Riluzole (1) It is dangerous goods. UN 2811 6.1/PG 3 (2) For amyotrophic lateral sclerosis therapy, prolong survival and / or time delayed tracheotomy. 2. Sinoway's advantage: (1) ISO 9001:2008 certificated company

Riluzole powder with GMP

Cas:1744-22-5

Min.Order:100 Gram

FOB Price: $100.0

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Riluzole Riluzole (Rilutek) is a drug used to treat amyotrophic lateral sclerosis. It delays the onset of ventilator-dependence or tracheostomy in selected patients and may increase survival by approximately two to thre

Riluzole Cas 1744-22-5 Research chemicals

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Riluzole manufacturer with low price

Cas:1744-22-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Riluzole 1744-22-5 GMP Manufacturer

Cas:1744-22-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Riluzole

Cas:1744-22-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Riluzole

Cas:1744-22-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Riluzole Basic information Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsun

Riluzole CAS:1744-22-5

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1744-22-5 with competitive price

Cas:1744-22-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Riluzole

Cas:1744-22-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Riluzole/ LIDE PHARMA- Factory supply / Best price

Cas:1744-22-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Riluzole Synonyms: 2-amino-6-trifluoromethoxy-benzothiazol;6-(trifluoromethoxy)-2-benzothiazolamin;amino-2trifluoromethoxy-6benzothiazole;2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole;RILUZOL

Riluzole CAS:1744-22-5

Cas:1744-22-5

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white crystalline solid Storage:ln stock Package:25kg/Barrel Application:a glutamate antagonist Transportation:Express/Sea/Air Port:Any port of china

High quality 98% Riluzole

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Benzothiazolamine,6-(trifluoromethoxy)- 1744-22-5

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

Riluzole CAS:1744-22-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, st

Riluzole CAS:1744-22-5

Cas:1744-22-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Benzothiazolamine,6-(trifluoromethoxy)-

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Lonwin Industry Group Limited. Lonwin Industry group limited as a professional manufactor & exporter of chemical materials ,we totally have more than 270 stuffs, we have been on this line for more than 9 years. Our chemical materials are expo

manufactory supply Intermediate API 99% Riluzole CAS 1744-22-5

Cas:1744-22-5

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

riluzole

Cas:1744-22-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Riluzole

Cas:1744-22-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Riluzole Synonyms: 2-amino-6-trifluoromethoxy-benzothiazol;6-(trifluoromethoxy)-2-benzothiazolamin;amino-2trifluoromethoxy-6benzothiazole;2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole;RILUZOLE GLUTAMATE RELEASE INH;2-AMINO-6-(TRIFL

Riluzole 99%

Cas:1744-22-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Riluzole CAS 1744-22-5 with Fast Shipment

Cas:1744-22-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

CP2010 standard have GMP Appearance:white to yellowish crystal or crystalline powder Storage:Room temperature preservation Package:25Kg/ paper drum Application:used for medicine Transportation:by sea by air express Port:china port

Riluzole China manufacture 98.5%min with GMP

Cas:1744-22-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Riluzole

Cas:1744-22-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Riluzole

Cas:1744-22-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Riluzole

Cas:1744-22-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Factory price sell 99.8% high purity Riluzole CAS:1744-22-5 ,manufacturer of China

Cas:1744-22-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery Appearance:White Crystalline Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:A neuroprotective agent. M

Riluzole

Cas:1744-22-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

potassium thioacyanate
333-20-0

potassium thioacyanate

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With bromine; acetic acid at 0 - 20℃; for 16h; Inert atmosphere;95%
Stage #1: 4-(trifluoromethoxy)aniline; potassium thioacyanate In acetic acid at 20℃; for 0.333333h;
Stage #2: With bromine In acetic acid at 20℃;
94%
Stage #1: 4-(trifluoromethoxy)aniline; potassium thioacyanate With acetic acid for 0.166667h;
Stage #2: With bromine
86%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With benzyltrimethylazanium tribroman-2-uide In acetonitrile at 20℃; for 24h;80%
With benzyltrimethylazanium tribroman-2-uide In acetonitrile at 20℃; for 24h;80%
With benzyltrimethylazanium tribroman-2-uide In acetonitrile80%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

tetrabutylammonium thiocyanate
3674-54-2

tetrabutylammonium thiocyanate

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With benzyltrimethylazanium tribroman-2-uide In dichloromethane at 20℃; for 18h;74%
3-(2-hydroxyethyl)-6-trifluoromethoxy-2-benzothiazoline hydrobromide

3-(2-hydroxyethyl)-6-trifluoromethoxy-2-benzothiazoline hydrobromide

Riluzole
1744-22-5

Riluzole

2-amino-4-nitro-6-trifluoromethoxy-benzothiazole
131395-13-6

2-amino-4-nitro-6-trifluoromethoxy-benzothiazole

2-amino-5-nitro-6-trifluoromethoxy-benzothiazole
131395-12-5

2-amino-5-nitro-6-trifluoromethoxy-benzothiazole

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
In water
2-hydrazinyl-6-(trifluoromethoxy)benzo[d]thiazole
133840-98-9

2-hydrazinyl-6-(trifluoromethoxy)benzo[d]thiazole

Riluzole
1744-22-5

Riluzole

ammonium thiocyanate

ammonium thiocyanate

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With bromine; acetic acid at 10 - 27℃; for 6.83333h;
C10H8F3N3O2S*ClH
1606922-37-5

C10H8F3N3O2S*ClH

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With blood peptidase
C11H10F3N3O2S*ClH

C11H10F3N3O2S*ClH

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With blood peptidase
2-(methylamino)-N-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]acetamide hydrochloride

2-(methylamino)-N-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]acetamide hydrochloride

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With blood peptidase
C15H16F3N3O4S*ClH

C15H16F3N3O4S*ClH

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane / 2 h
2: blood peptidase
View Scheme
C16H18F3N3O4S*ClH

C16H18F3N3O4S*ClH

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane / 2 h
2: blood peptidase
View Scheme
C16H18F3N3O4S*ClH

C16H18F3N3O4S*ClH

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane / 2 h
2: blood peptidase
View Scheme
N-<4-(trifluoromethoxy)phenyl>thiourea
142229-74-1

N-<4-(trifluoromethoxy)phenyl>thiourea

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
With bromine; acetic acid; lithium bromide at 40℃;
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Riluzole
1744-22-5

Riluzole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / Isopropyl acetate / 16 h / Reflux
2: acetic acid; lithium bromide; bromine / 40 °C
View Scheme
trifluoromethyl trifluoromethanesulfonate
3582-05-6

trifluoromethyl trifluoromethanesulfonate

Riluzole
1744-22-5

Riluzole

1,3-bis(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)urea

1,3-bis(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)urea

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h; Sealed tube;96%
Riluzole
1744-22-5

Riluzole

N-allyl isothiocyanate
57-06-7

N-allyl isothiocyanate

1-allyl-3-(6-trifluoromethoxy-1,3-benzothiazol-2-yl)thiourea

1-allyl-3-(6-trifluoromethoxy-1,3-benzothiazol-2-yl)thiourea

Conditions
ConditionsYield
In ethanol for 16h; Reflux;95%
(5R,8R)-9-oxo-5,6,7,9-tetrahydro-8H-5,8-methanobenzo[7]annulene-8-carboxylic acid

(5R,8R)-9-oxo-5,6,7,9-tetrahydro-8H-5,8-methanobenzo[7]annulene-8-carboxylic acid

Riluzole
1744-22-5

Riluzole

(5R,8R)-9-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)-5,6,7,9-tetrahydro-8H-5,8-methanobenzo[7]annulene-8-carboxamide

(5R,8R)-9-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)-5,6,7,9-tetrahydro-8H-5,8-methanobenzo[7]annulene-8-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 15h;94%
2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetic acid
763903-09-9

2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetic acid

Riluzole
1744-22-5

Riluzole

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide
1392441-96-1

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 24h;80%
Stage #1: Riluzole With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
Stage #2: 2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetic acid In dichloromethane at 25℃; for 24h;
80%
p-cyanophenyl isocyanate
40465-45-0

p-cyanophenyl isocyanate

Riluzole
1744-22-5

Riluzole

1-(4-cyanophenyl)-3-(6-trifluoromethoxybenzothiazol 2-yl)urea
1343448-00-9

1-(4-cyanophenyl)-3-(6-trifluoromethoxybenzothiazol 2-yl)urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 5h;93%
methanol
67-56-1

methanol

Riluzole
1744-22-5

Riluzole

N-methyl-6-(trifluoromethoxy)benzo[d]thiazol-2-amine
133840-97-8

N-methyl-6-(trifluoromethoxy)benzo[d]thiazol-2-amine

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide at 150℃; for 12h; Inert atmosphere; Schlenk technique; Green chemistry;92%
para-fluorophenyl isocyanate
1195-45-5

para-fluorophenyl isocyanate

Riluzole
1744-22-5

Riluzole

1-(4-fluorophenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)urea
1343447-98-2

1-(4-fluorophenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 5h;91%
Riluzole
1744-22-5

Riluzole

2-hydrazinyl-6-(trifluoromethoxy)benzo[d]thiazole
133840-98-9

2-hydrazinyl-6-(trifluoromethoxy)benzo[d]thiazole

Conditions
ConditionsYield
With hydrazine dihydrochloride; hydrazine hydrate In ethylene glycol at 140℃; for 2h;90%
With hydrazine hydrate; hydrazinium sulfate In water at 130℃; for 4h; Inert atmosphere;75%
With hydrazinium sulfate; hydrazine In ethylene glycol at 140℃; for 2.5h;65%
With hydrazine
With hydrogenchloride; hydrazine hydrate for 5h; Reflux;
Riluzole
1744-22-5

Riluzole

butan-1-ol
71-36-3

butan-1-ol

2-(N-n-butylamine)-6-trifluoromethoxy-benzothiazole
1353280-38-2

2-(N-n-butylamine)-6-trifluoromethoxy-benzothiazole

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide at 150℃; for 12h; Inert atmosphere; regioselective reaction;90%
carbon monoxide
201230-82-2

carbon monoxide

N-(2'-iodo-[1,1'-biphenyl]-2-yl)-N-methylacrylamide

N-(2'-iodo-[1,1'-biphenyl]-2-yl)-N-methylacrylamide

Riluzole
1744-22-5

Riluzole

(aR,S)-2-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)acetamide

(aR,S)-2-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)acetamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); C25H23OP; caesium carbonate In toluene at 40℃; under 760.051 Torr; for 10h; Schlenk technique; stereoselective reaction;88%
Riluzole
1744-22-5

Riluzole

benzyl alcohol
100-51-6

benzyl alcohol

N-benzyl-6-(trifluoromethoxy)benzo[d]thiazol-2-amine
1307865-22-0

N-benzyl-6-(trifluoromethoxy)benzo[d]thiazol-2-amine

Conditions
ConditionsYield
With copper(l) chloride; sodium hydroxide In para-xylene at 160℃; for 12h; Inert atmosphere; regioselective reaction;87%
4-Methoxyphenyl isocyanate
5416-93-3

4-Methoxyphenyl isocyanate

Riluzole
1744-22-5

Riluzole

1-(4-methoxyphenyl)-3-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)urea
1343447-99-3

1-(4-methoxyphenyl)-3-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 5h;84%
mercaptoacetic acid
68-11-1

mercaptoacetic acid

2,3-dichlorobenzylaldehyde
6334-18-5

2,3-dichlorobenzylaldehyde

Riluzole
1744-22-5

Riluzole

3-(6-trifluoromethoxy-benzo[d]thiazol-2-yl)-2-(2,3-dichlorophenyl)thiazolidin-4-one

3-(6-trifluoromethoxy-benzo[d]thiazol-2-yl)-2-(2,3-dichlorophenyl)thiazolidin-4-one

Conditions
ConditionsYield
In ethanol at 100℃; for 0.5h; Sealed tube; Microwave irradiation;84%
methanol
67-56-1

methanol

6-Chloro-4-oxo-4H-chromene-3-carbaldehyde
42248-31-7

6-Chloro-4-oxo-4H-chromene-3-carbaldehyde

Riluzole
1744-22-5

Riluzole

C19H12ClF3N2O4S

C19H12ClF3N2O4S

Conditions
ConditionsYield
at 30 - 40℃; for 10h; stereoselective reaction;82%
(E)-2-(2-methoxy-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetic acid
1357099-42-3

(E)-2-(2-methoxy-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetic acid

Riluzole
1744-22-5

Riluzole

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy}acetamide
1379509-97-3

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy}acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;81%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 24h;80%
Stage #1: Riluzole With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
Stage #2: (E)-2-(2-methoxy-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetic acid In dichloromethane at 25℃; for 24h;
80%
2,6-difluorophenyl isocyanate

2,6-difluorophenyl isocyanate

Riluzole
1744-22-5

Riluzole

1-(2,6-difluorophenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)urea
1343448-03-2

1-(2,6-difluorophenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 5h;81%
2-{5-[1-acetyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid
1392443-96-7

2-{5-[1-acetyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid

Riluzole
1744-22-5

Riluzole

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{5-[1-acetyl-3-(3,4,5-trimethoxy phenyl)-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetamide
1392442-07-7

N1-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{5-[1-acetyl-3-(3,4,5-trimethoxy phenyl)-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 24h;80%
Stage #1: Riluzole With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
Stage #2: 2-{5-[1-acetyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid In dichloromethane at 25℃; for 24h;
80%
Hexafluoroacetone
684-16-2

Hexafluoroacetone

Riluzole
1744-22-5

Riluzole

N-(2,2,2-trifluoro-1-trifluoromethylethylidene)-6-(trifluoromethoxy)benzothiazol-2-ylamine

N-(2,2,2-trifluoro-1-trifluoromethylethylidene)-6-(trifluoromethoxy)benzothiazol-2-ylamine

Conditions
ConditionsYield
Stage #1: Hexafluoroacetone; Riluzole With pyridine In benzene at 20℃; for 0.5h;
Stage #2: With thionyl chloride In benzene for 1h;
79%
methyl 3,3,3-trifluoropyruvate
13089-11-7

methyl 3,3,3-trifluoropyruvate

Riluzole
1744-22-5

Riluzole

methyl 3,3,3-trifluoro-2-(6-(trifluoromethoxy)benzothiazol-2-ylimino)propionate

methyl 3,3,3-trifluoro-2-(6-(trifluoromethoxy)benzothiazol-2-ylimino)propionate

Conditions
ConditionsYield
Stage #1: methyl 3,3,3-trifluoropyruvate; Riluzole With pyridine In benzene at 20℃; for 0.5h;
Stage #2: With thionyl chloride In benzene for 1h;
78%
methyl hydrogen succinate
3878-55-5

methyl hydrogen succinate

Riluzole
1744-22-5

Riluzole

N-(6-trifluoromethoxy-benzothiazol-2-yl)-succinamic acid methyl ester
1394929-73-7

N-(6-trifluoromethoxy-benzothiazol-2-yl)-succinamic acid methyl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 96h;77%
Riluzole
1744-22-5

Riluzole

2-amino-4-bromo-6-trifluoromethoxy-benzothiazole hydrobromide
144864-70-0

2-amino-4-bromo-6-trifluoromethoxy-benzothiazole hydrobromide

Conditions
ConditionsYield
With bromine In acetic acid at 50℃; for 12h;76%
2-hydroxy-5-t-butylisophthalaldehyde
84501-28-0

2-hydroxy-5-t-butylisophthalaldehyde

Riluzole
1744-22-5

Riluzole

C20H17F3N2O3S

C20H17F3N2O3S

Conditions
ConditionsYield
In ethanol at 20℃;75%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Riluzole
1744-22-5

Riluzole

N-[6-(trifluoromethoxy)benzo[d]thiazol-2-yl]methanesulfonamide

N-[6-(trifluoromethoxy)benzo[d]thiazol-2-yl]methanesulfonamide

Conditions
ConditionsYield
With triethylamine In benzene for 2h;75%
Riluzole
1744-22-5

Riluzole

propoxycarbonyl chloride
109-61-5

propoxycarbonyl chloride

(6-trifluoromethoxy-benzothiazol-2-yl)-carbamic acid propyl ester
1394929-66-8

(6-trifluoromethoxy-benzothiazol-2-yl)-carbamic acid propyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 24h;74%
cycloheptanecarbonyl chloride
6557-86-4

cycloheptanecarbonyl chloride

Riluzole
1744-22-5

Riluzole

N-[6-(trifluoromethoxy)benzothiazol-2-yl]cycloheptanecarboxamide

N-[6-(trifluoromethoxy)benzothiazol-2-yl]cycloheptanecarboxamide

Conditions
ConditionsYield
In dichloromethane at 20℃;73%
In dichloromethane at 20℃;
2,6-dichlorobenzaldehyde
83-38-5

2,6-dichlorobenzaldehyde

mercaptoacetic acid
68-11-1

mercaptoacetic acid

Riluzole
1744-22-5

Riluzole

3-(6-trifluoromethoxy-benzo[d]thiazol-2-yl)-2-(2,6-dichlorophenyl)thiazolidin-4-one

3-(6-trifluoromethoxy-benzo[d]thiazol-2-yl)-2-(2,6-dichlorophenyl)thiazolidin-4-one

Conditions
ConditionsYield
In ethanol at 100℃; for 0.5h; Sealed tube; Microwave irradiation;73%
n-hexyl chloroformate
6092-54-2

n-hexyl chloroformate

Riluzole
1744-22-5

Riluzole

(6-trifluoromethoxy-benzothiazol-2-yl)-carbamic acid hexyl ester

(6-trifluoromethoxy-benzothiazol-2-yl)-carbamic acid hexyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 24h;72%

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