Two new imidazole salts, namely, [HIMT]+ X (X = NO3–) (1), ClO4– (2) [IMT = 4-((1H-imidazol-1-yl)methyl)benzonitrile], were grown through reacting IMT and two different inorganic acids by slow evaporation method, respectively. Salts 1 and 2 have been characterized by single–crystal X–ray dif...

Neutral sphingomyelinase 2 (nSMase2), a key enzyme in ceramide biosynthesis, is a new therapeutic target for the treatment of neurological disorders and cancer. Using 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol (DPTIP), our initial hit compound (IC50 = 30 nM) from nSMase2 scr...

Fluoride coordination derivatives of niobium(V) were tested for their activation capabilities with respect to acetone and to olefins. Activation of acetone (formation of mesityloxide) was observed with NbF4(OMe). Several fluoride coordination derivatives of niobium(V) of different nature (neutra...

The [ReCl3(MeCN)(PPh3)] complex reacts with 1-isoquinolinyl phenyl ketone (N–O) to give [ReCl3(N–O)(PPh3)]. The compound has been studied by IR, UV–Vis spectroscopy, magnetic measurements and X-ray crystallography. The magnetic behavior is characteristic of mononuclear octahedral Re(III) comp...

Catalytic Meerwein–Ponndorf–Verley (MPV) reduction using AlIII–calix[4]arene complexes is investigated as a model system that requires the bringing together of two different chemical species, ketone and alkoxide, within a six-membered transition state. Two-point versus one-point ketone bindin...

This paper describes the improved synthesis of n.c.a. 4- 18F]fluorophenol for the preparation of 18F-labeled alkylarylethers. Nucleophilic fluorination of substituted benzophenone derivatives yielded n.c.a. 4- 18F]fluoro-4′-substituted benzophenones with 80– 90 % RCY, which were converted to b...

The FT-IR and FT-Raman spectra of 3,3′-bis (trifluoromethyl) benzophenone (TFMBP) were recorded and analyzed. Natural bond orbital analysis on TFMBP, 3,3′-bis (trichloromethyl) benzophenone (TCMBP) and 3,3′-bis (tribromomethyl) benzophenone (TBMBP) has been carried out for various intramolecu...

The acute toxicity of a candidate antimalarial drug, 4-fluoro-4′-trifluoromethyl benzophenone guanylhydrazone hydrochloride (FTBG; WR 09792), was measured by intraperitoneal and oral administration to mice, rats, and guinea pigs. The LD50 values were between 11.5 and 27.9 mg/kg by the intraperi...

Combretastatin A-1 (CA-1) and combretastatin A-4 (CA-4) isolated from the African bush willow Combretum caffrum are highly potent tubulin polymerization inhibitors, possessing strong antitumor activities because of their vascular disrupting properties. Extensive SAR studies have been done for CA...

Optimum conditions were found for the reaction of Au(III) with bromopyrogallol red and a new spectrophotometric determination of Au(III) ions was developed. At a wavelength of 400 nm the Lambert-Beer law is followed in a range of 0.1 to 3.0 μg Au ml−1 and the absorption coefficient ϵ = 3 × 104...

The solubilization site of bromopyrogallol red (BPR) in cetyltrimethylammonium bromide (CTAB)/Triton X-100(TNX) mixed micellar solutions was studied by the pulsed FT NMR technique. The changes in the chemical shifts of the individual groups of protons in the two surfactant molecules indicated th...

Complexation of bromopyrogallol ligand with di(aqua)bis(oxalato)iron(II) moiety, [Fe(II)(H2O)2(C2O4)1]2−, shows enhanced photovoltaic properties when compared with the photovoltaic cells coated by bromopyrogallol ligand only. Electrochemical and absorption spectroscopic data suggest the nature o...

Bromopyrogallol red, BPR, (2-(2,7-dibromo-4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl) benzenesulphonic acid, Scheme 1) as a new chromogenic anion receptor, can selectively and efficiently be applied for detection of AcO− over wide range of anions such as BzO−, F−, Cl−, Br−, OH−, I−, NO3−, HSO4−, CN−...

A spectrophotometric investigation of the Ti(IV)-bromopyrogallol red chelate shows that marked changes occur in the presence of aqueous dispersions of cetylpyridinium bromide. The increase in the absorption and the bathochromic shifts are interpreted in terms of the interaction of the binary com...

Bromopyrogallol red is used as a hydrogen donor substrate for peroxidase. The steady-state catalytic rate depends upon enzyme and substrate concentrations, and the Michaelis–Menten parameters Km and Vmax are measured at pH 6.2 to be 2.07×10−5 mol l−1 and 1.62×10−7 mol l−1 s−1, respectively. T...

The mechanism of binding of bromopyrogallol red (BPR) with bovine serum albumin (BSA) was investigated by fluorescence, absorption, circular dichroism (CD) and lifetime measurements. The analysis of fluorescence data indicated the presence of both dynamic and static quenching mechanism in the bi...

In this work, the speciation analysis of inorganic antimony (Sb(III) and Sb(V)) is proposed using polyurethane foam loaded with bromopyrogallol red (PUF-BPR) as a selective sorbent for Sb(III). The quantification of Sb in the solutions was performed by graphite furnace atomic absorption spectrom...

This paper summarizes the results of a degradation test of bromopyrogallol red (BPR) and textile dye wastewater (TDW) with a conventional three-electrode potentiostatic system in the presence of cobalt ions (electro Co2+–H2O2 system). H2O2, produced by the two-electron reduction of O2 at the ca...

We report bromopyrogallol red (BPR) as an easily available dye for detection of copper and chloride with distinct visual color changes in DMSO/H2O (9:1 v/v). The chemosensor has a high chromogenic selectivity for Cu2+ over other cations with detection limit of 0.07 μg mL−1. The obtained complex...

A series of 4-anilino-2-(2-pyridyl)pyrimidines has been discovered as a new class of potent inducers of apoptosis using a cell-based HTS assay. Compound 5a was found to arrest T47D cells in G2/M and induced apoptosis. SAR studies showed that a small and electron-donating group at the meta-positi...