New quinoline compounds comprising pyrazole scaffold through different amide linkages were synthesized. The synthesized compounds were evaluated for their anti-inflammatory activity. Eight compounds (5c, 11b,c, 12c, 14a,b, 20a and 21a) were found to exhibit promising anti-inflammatory profiles i...

Chitooligosaccharides (COS) produced by nitrous acid depolymerization of chitosan are unique chitosan oligomers due to the presence of the 2,5-anhydro-d-mannofuranose (amf) unit at their reducing end. In this work, we focused on the reductive amination and the oximation of the amf aldehyde group...

This study aimed to investigate the possible alleviating effect of chitosan on salt-induced growth retardation and oxidative stress and to elucidate whether this effect is linked to activation of mitochondrial respiration on the basis of alternative respiration in maize seedlings. Salt stress si...

In this study, chitosan (CS) was degraded by ascorbate radical (Asc•−) and hydroxyl radical (•OH), respectively. The structural, physicochemical, antioxidant and film forming properties of Asc•− and •OH degraded CS were compared for the first time. Results showed the structure and physicochemica...

Chitosan, possessing excellent properties, has been drawing broad attention. For the further utilization of chitosan, chemical modification is performed in improving its water solubility and the bioactivities. In the current study, four N,N,N-trimethyl chitosan salts, including N,N,N-trimethyl c...

A magnetic chitosan-based biocomposite, [email protected]@Chitosan/Cu, was prepared and used as an efficient heterogeneous catalyst for the synthesis of triazoles. The structure, thermal stability and magnetic properties of the composite were investigated by FT-IR, XRD, SEM, TEM, TGA, and VSM me...

Chitosan nanoparticles have many applications, such as gene and drug delivery, due to their biocompatibility. Chitosan nanoparticles are currently produced by dissolution in acetic acid that affects the biocompatibility at acidic pH. Here, we synthesized and characterized chitosan (CS) and ascor...

In the present study, a bilayer film composed of chitosan and alginate was produced by layer-by-layer casting and crosslinking by oxidized ferulic acid. The effects of different film components on mechanical, permeable and optical properties of the film were systematically investigated and the o...

The most important prerequisites for wound coverage matrices are biocompatibility, adequate porosity, degradability and exudate uptake capacity. A moderate hydrophilicity and exudate uptake capacity can often favour cell adhesion and wound healing potential, however, most of the synthetic polyme...

This study focuses on synthesis and characterization of chitosan ascorbate nanoparticles (CANs) from a salified carboxylate form of chitosan with ascorbic acid. Evident changes were observed in crystallinity and structure of CANs from their parent polymer. CANs exhibited improved antioxidative p...

sds22 was originally identified in yeast as a regulator of protein phosphatase-1 that is essential for the completion of mitosis. We show here that a structurally related mammalian polypeptide (41.6 kDa) is part of a 260-kDa species of protein phosphatase-1. This holoenzyme, designated PP-1Nsds2...

Background: Cell cycle progression requires the activity of protein kinases and phosphatases at critical points in the cell cycle in all eukaryotes. We have previously reported that the dis2+ and sds2+ genes of fission yeast encode redundant catalytic subunits of a type 1-like protein phosphatas...

The protein kinase Rad53 and its orthologs play a fundamental role in regulating the DNA damage checkpoint in eukaryotes. Rad53 is activated by phosphorylation in response to DNA damage and deactivated by dephosphorylation after the damage is repaired. However, the phosphatases involved in Rad53...

Protein phosphatases play a crucial role in cell cycle progression, cell survival, cellular signaling, and genomic integrity. The protein phosphatase 1 (PP1) regulatory subunit SDS22 plays a significant role in cell cycle progression. A recent study showed that SDS22 plays a vital role in epithe...

SummarySDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich repeats adopt a banana-shaped fold that is shielded from solvent by capping domains at its extremities. Subsequent modeling and biochemical studies revealed that...

Studies to identify novel immune-regulatory functions of active vitamin D (1,25(OH)2D3) in human CD4+ T cells revealed that 1,25(OH)2D3 potently induced expression of the gene SERPINA1, encoding the anti-protease α-1-antitrypsin. We confirmed α-1-antitrypsin protein expression by 1,25(OH)2D3-t...

SummaryFusobacterium nucleatum in the tumor microenvironment plays an important role in the development of colorectal cancer. The underlying mechanism of action, however, remains to be elucidated. We evaluated the relation of F nucleatum amount to thymocyte selection-associated high-mobility gro...

Background & AimsThe thymocyte selection-associated high mobility group box protein (TOX) plays a vital role in T cell development and differentiation, however, its role in T cell exhaustion was unexplored. Here, we aim to investigate the role of TOX in regulating antitumor effect of CD8+ T cell...

We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS.Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, B...

IntroductionSpecific TSH and free thyroxine ranges are needed to adequately assess maternal thyroid function during pregnancy.