Cytosolic prenyl transferases from two human lymphoid tissue-derived cell lines, IM-9 and Molt-4 cells, are shown to isoprenylate recombinant p21H-ras. Isoprenylation was inhibited by an N-acetylated pentapeptide (N-Ac-Lys-Cys-Val-Leu-Ser), c, t-farnesyl diphosphate, c, t, t-geranylgeranyl dipho...

Asymmetric Friction Connections (AFCs) are used to dissipate seismic energy via friction. AFC strength is affected by moment–axial force–shear force (MPV) interaction. Current MPV models do not consider the increase in bolt tension due to bolt rotation as bolts are assumed to yield axially dur...

Homoleptic tris(triazenido) derivatives of ruthenium, osmium, rhodium and iridium, M(ArNNNAr)3 (Ar = p-C6H4X; X = H, Me or Cl), have been prepared by treatment of the chlorides or chloro complexes—RuCl3(aq.), (NH4)2OsCl6(aq.), RhCl3(aq.) and (NH4)2IrCl6(aq.), respectively—with excess 1,3-diary...

Ruthenium(III) ion-exchanged zeolite Y, prepared by ion exchange of Ru+3 ions with the extra framework Na+ cations in zeolite Y with a Si/Al ratio of 2.5, is employed to catalyze the decomposition of nitrous oxide to nitrogen and oxygen. Catalytic activity of ruthenium(III) ion-exchanged zeolite...

Polynuclear sulfur bridged complexes where the neutral complex tris(2-aminoethanethiolato)cobalt(III) acts as a tridentate ligand to rhodium(III), iridium(III) and osmium(III) have been prepared. These complexes have been characterized by electronic spectroscopy, vibrational spectroscopy and nuc...

A facile, efficient and eco-friendly method for the one-pot synthesis of 1,2/3-triols from the allylic hydroperoxides were developed by using zeolite-confined osmium(0) nanoclusters as reusable catalyst and without using any co-oxidant (H2O2, tBuOOH, NMO, etc.) in water/acetone (v/v = 1/4) mixtu...

SummaryChemotactic factors, arachidonic acid and leukocyte-derived lipoxygenase products of arachidonate (5-hydroperoxy-, 5-hydroxy- and 5,12-dihydroxy-eicosatetraenoic acids) stimulated stereospecific uptake of 3H-2-deoxyglucose by human neutrophils. However, of all stimuli tested, only the eff...

Summary3-Hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE) is a biologically active compound which has a signal transducing role in human neutrophils. When 12.5 mg/l arachidonic acid (AA) was fed to sexual reproductive cells of Dipodascopsis uninucleata and D. tóthii the former transformed appro...

When arachidonic acid (AA) is added to the yeast Dipodascopsis uninucleata UOFS Y128, one of the major metabolites isolated and purified with the help of thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) is 3-hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE). The s...

2′-modified ribonucleosides (2′-methoxyethoxy- O, 2′-fluoro-2′-deoxypyrimidines O and 2′-amino-2′-deoxyuridines □) were introduced into hammerhead ribozymes. Kinetics and stability assays were performed. The lipophilicity characteristics of these 2′-modifications were investigated measur...

The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, ...

A new 2-(2-methoxyethoxy)ethyl ester of Monensin A (MON7) has been synthesized and its capability of complex formation with Li+, Na+, and K+ cations has been studied by ESI MS, 1H and 13C NMR, FT-IR, and PM5 semiempirical methods. ESI mass spectrometry indicates that MON7 forms complexes with Li...

Dissolution enthalpies of NaCl and NaI in aqueous solution of 2-(2-methoxyethoxy)ethanol (C1E2) and 2-isopropoxyethanol (iC3E1) have been measured and appropriate enthalpic pair interaction coefficients, hxy (electrolyte–non-electrolyte), in water have been determined at 298.15 K. Our investiga...

A novel stable self-assembled chemisorbed layers, providing protection of metal surface against electrooxidation capable of blocking propylene carbonate (PC) electroreduction and Li electrodeposition, were produced from 3-[tris-(2-methoxyethoxy)silyl]-propanethiol (SIS2) on silver. Reflection-ab...

The advent of microarray technology, coupled with the availability of mouse cDNA collections derived specifically from preimplantation embryos, helps to provide global gene expression profiles for the earliest stages of development. However, to determine the functions of the large numbers of gen...

The innovative use of silver(I)-2-[2-(2-methoxyethoxy)ethoxy]acetate ([AgO2C(CH2OCH2)3H], 3) as precursor for the deposition of silver on float glass by applying the atmospheric pressure combustion chemical vapor deposition process is described. As nucleation layer tungsten oxide was utilized, c...

Platelet-derived growth factor receptor β (PDGFRβ) is a transmembrane tyrosine kinase receptor and it is upregulated in various malignant tumors. Radiolabeled PDGFRβ inhibitors can be a convenient tool for the imaging of tumors overexpressing PDGFRβ. In this study, [125I]-1-{5-iodo-2-[5-(2-m...

This study examines the transformation and removal of the atypical antipsychotics amisulpride and sulpiride and the anticonvulsant lamotrigine in municipal wastewater treatment plants (WWTPs). Amisulpride, sulpiride and lamotrigine were selected using a tailored non-target screening approach. In...

The novel triple reuptake inhibitor (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine monohydrochloride 1 possesses a unique 2-phenyl-2-(piperidin-4-yl)ethanol moiety with a stereogenic center at the benzyl position. To synthesize 1 as the (S)-isomer, three possible routes were investigate...

Phosphodiesterase-5 (PDE5) inhibitors have been approved for the treatment of erectile dysfunction and pulmonary hypertension, but enthusiasm on discovery of PDE5 inhibitors continues for their potential new applications. Reported here is discovery of a series of new PDE5 inhibitors by structure...