The interaction of tropomyosin-related kinase B (TrkB) with the cognate ligand brain-derived neurotrophic factor (BDNF) mediates fundamental pathways in the development of the nervous system. TrkB signaling alterations are linked to numerous neurodegenerative diseases and conditions. Herein we r...

Lipids are susceptible to damage by reactive oxygen species, and from lipid oxidation reactions many short chain lipid peroxidation products can be formed. 4-Hydroxy-2-nonenal (HNE) is one of the most abundant and cytotoxic lipid oxidation products and is known to form covalent adducts with nucl...

Axl is a tyrosine kinases receptor playing crucial role in several cellular responses. The deregulation of Axl signaling has been associated to many high impact diseases ranging from cancer to multiple sclerosis. We report the successful procedure for the chemical synthesis of the Ig2 domain of ...

A series of fluorobenzoylated di- and tripeptides as potential leads for the development of molecular probes for imaging of COX-2 expression was prepared according to standard Fmoc-based solid-phase peptide synthesis. All peptides were assessed for their COX-2 inhibitory potency and selectivity ...

A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a–f and 3a–q exhibited higher activities than fluconazole against nearly all fung...

ObjectiveThis study aimed to determine whether the R-enantiomer of 8-hydroxy-2-(di-n-propylamino) tetralin (R-8-OH-DPAT) alleviates respiratory depression in antelope species immobilised with etorphine. The experiment also aimed to establish the most clinically effective dose of this serotonin 5...

2-(N-Phenylamino)propanoic acid 1a and 3-(N-phenylamino)-propanoic acid 2a together with four of their aryl analogues were pyrolysed in the gas-phase. The reactions were homogeneous and free from catalytic and radical pathways. Analysis of the pyrolysate of 1 showed the elimination products to b...

Propylene polymerization mechanism was investigated with density functional theory (DFT) using TiCln(OR)(4–n) catalysts, with active centers such as [TiCl2Et]+, [TiCl(OEt)Et]+, [TiCl(OPh)Et]+, or [Ti(OEt)2Et]+. Improving the stereoselectivity of Ziegler–Natta catalyst through introducing alkox...

High-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC–ESI–MS) was utilized for the rapid, on-line detection of all six forms of inositol phosphate (InsP) in seven major tree nuts (i.e., cashews, Brazil nuts, macadamias, walnuts, pecans, pistachios,...

The extraction and measurement of all six forms of inositol phosphates (InsPs) in almond meal and brown skins were improved from existing methods by pH adjustment, supplementation of EDTA, and rapid analysis via anion-exchange high-performance liquid chromatography coupled with electrospray ioni...

d-myo-Inositol hexakisphosphate (InsP6, phytate), a normal cellular constituent, was found to be toxic to neuronal perikarya when injected into the rat hippocampus. However, the extrinsic cholinergic innervation of the hippocampus (as estimated by staining for acetylcholinesterase) was unaffecte...

The syntheses of the following chiral compounds are described: 1d-2,3,6-tri-, 1d-2,4,5-tri-, 1d-2,5,6-tri-, 1d-1,2,3,4-tetra-, 1d-1,2,3,6-tetra-, 1d-1,2,4,5-tetra-, and 1d-2,3,5,6-tetra-O-benzyl-myo-inositol; and 1d-2,5,6-tri-O-benzyl-1-O-p-methoxybenzyl- and 1d-2,3,5,6-tetra-O-benzyl-1-O-p-meth...

The 1,4,5-tris-, 1,3,4-tris-, and 1,3,4,5-tetrakis-phosphates of 1d-myo-inositol have been prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. A facile enzymic preparation is also described of these chiral intermediates through ena...

Alfa-trinositol (or d-myo-inositol 1,2,6-trisphosphate) was recently found to, e.g., inhibit agonist-induced vasoconstriction and display antiinflammatory properties. However, its mechanism of action is unknown, although effects on Ca2+ fluxes, perhaps by interfering with endogenous inositol pho...

Two new multivalent ligands 1 and 2, based on calix[4]arene and thiacalix[4]arene backbones in 1,3-Alternate conformation, bearing four iminocatechol coordinating units have been prepared and structurally characterized both in solution and in the crystalline phase. Combinations of compounds 1 an...

Redox behaviors of electrochemically active self-assembled monolayers (SAMs) prepared on gold surfaces from ferrocene (Fc)-terminated alkanethiols were investigated in more depth in response to the authors' previous study where ionic liquids (ILs) with bis[(trifluoromethyl)sulfonyl]amide (T...

Sulfonyl(trifluoromethylsulfonyl) imide anion (STFSI, SO2N(−)SO2CF3) is one of the most important sulfonimide groups for organic and material synthesis. However, the synthesis of STFSI-functionalized monomers and related polymers is still a problematic issue, comprising multi-step and complex sy...

Porphyrins that bear one-carbon oxygenic substituents (hydroxymethyl, formyl, ester) directly attached to the macrocycle afford a compact architecture of utility for diverse applications. Routes to 9 porphyrins bearing such groups in distinct architectures (A4-, trans-A2-, trans-A2B2-, trans-AB-...

This study aimed to obtain ethyl esters (EEs) from macauba pulp crude oil, using heterogeneous-acid catalyst, varying the temperature of (trans)esterification, ethanol-to-oil molar ratio (MR) and catalyst content. Catalyst Amberlyst 15 characterization showed high concentrations of active sites ...

Fatty acid ethyl esters (FAEEs) can potentially be used as biodiesel, which provides a renewable alternative to petroleum-derived diesel. FAEEs are primarily produced via transesterification of vegetable oil with an alcohol catalyzed by a strong base, which raises safety concerns. Microbial prod...