In the present study, the in-situ synthesized mullite has been prepared successfully by mixing kaolinite with alumina and aluminum nitrate nonahydrate (ANN) powders through high energy milling followed by spark plasma sintering (SPS). Using a high-energy ball-mill, the stoichiometric composition...

Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acety...

The fabrication of dense alumina fibers at low cost by sol-gel and electrospinning, using aluminum nitrate as precursor is reported. Polyvinyl pyrrolidone was used as spinning polymer, while Pluronic 127 was used as additive to achieve a porous structure. The material was characterized at differ...

This contribution is devoted to the new ytterbium-doped alkali metal lutetium double phosphates and their structural and spectroscopic characterisations. The absorption, emission and excitation spectra have been measured at 4, 10 and 293 K in the VUV to IR range. The results have been compared w...

There is growing interest on the role of the lateral habenula (LHb) in depression, because it closely and bilaterally connects with the serotoninergic raphe nuclei. The LHb sends glutamate efferents to the raphe nuclei, while it receives serotoninergic afferents, and expresses a high density of ...

A series of novel N4-substituted 4-(2-aminoethyl)benzenesulfonamides 5–17 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), that is the cytosolic CA I and II, and tumor-associated isozymes CA IX and XII. Against the human C...

Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline a...

2-Aminoethyl diphenylborinate (2-APB) is a known modulator of the IP3 receptor, the calcium ATPase SERCA, the calcium release-activated calcium channel Orai and TRP channels. More recently, it was shown that 2-APB is an efficient inhibitor of the epithelial calcium channel TRPV6 which is overexp...

A simple four-step synthesis of 4-(2-aminoethyl)-5-hydroxy-1H-pyrazoles 8 (or their 1H-pyrazol-3(2H)-one tautomers 8′) as the pyrazole analogues of histamine was developed. First, enamino lactam 3 was prepared as the key intermediate in two steps from 2-pyrrolidinone (1). Next, acid-catalysed ‘...

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-phenyl benzamides as a starting point for hit-to-lead medicinal chemistry. Eighty two analogues ...

Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes. Heparan sulfate penetrates the membrane and is transported to the nucleus. This process is dependent on copper and on expression and processing of the amyloid precur...

The binding of actinomycin D (C1, 1) and its analog actinomin (2) was studied on base-modified oligonucleotide duplexes with parallel chain orientation (ps) and with anti-parallel chains (aps) for comparison. Actinomycin D binds not only to aps duplexes containing guanine–cytosine base pairs bu...

Pulsed nuclear quadrupole resonance (NQR) measurements have been performed on claudetite I and arsenolite from 4.2K to 300K. As expected, from X-ray results, two inequivalent but nearly degenerate As sites are observed in claudetite I and one As site is observed in arsenolite. The temperature de...

The reactions of electron acceptors such as picric acid (HPA) and 7,7′,8,8′-tetracyano-p-quinodimethane (TCNQ) with 2-hydroxypyridine (HPyO) have been investigated in EtOH at room temperature. Based on elemental analysis and IR spectra of the solid CT-complexes along with the photometric titra...

Katritzky's oxopyridinium betaine cycloaddition is employed to generate bridged bicyclic substrates suitable for our palladium(0) catalysed cyclisation–anion capture methodology. A variety of polycyclic heterocycles have been synthesised via monocyclisation–organotin(IV) capture with or w...

The molecular complex of N-ethyl-3-hydroxypyridinium hydrogen squarate has been obtained and characterized by single-crystal X-ray diffraction, B3LYP/6-311++G(d,p) calculations, Raman, FTIR and NMR spectra. The complex is built of OH⋯O hydrogen-bonded dimer involving two anions and two cations. ...

The new complexes [Zn(pyot)2(en)2] (1), [Zn(mphot)2(en)2] (2), [Zn(bhpzdtc)2(py)] (3), [Zn(bhpzdtc)2(4-pic)] (4) and [Zn(ecpzdtc)(bpy)(Cl)] (5) {pyot = 5-(4-pyridyl)-1,3,4-oxadiazole-2-thione, mphot = 5-(4-methoxy phenyl)-1,3,4-oxadiazole-2-thione, bhpzdtc = 1-benzhydrylpiperazine dithiocarbamat...

Diabetes is a major public health problem. Development of new therapies that are able to improve glycemia management, cure diabetes, and can even protect from it, are of great interest. This study investigated the protective effect of sodium tungstate against STZ-induced beta-cell damages by mea...

A calorimetric investigation on the thermodynamic properties of cesium uranyl tungstate, Cs8UO24WO44WO52, was undertaken. In addition, model calculations on its thermodynamic behaviour in aqueous solution were made. Cs8UO24WO44WO52 was synthesized for the first time by high-temperature solid-sta...

This paper presents the results obtained when studying the removal of molybdate and tungstate anions from aqueous using organically modified montmorillonite. In batch experiments, the influence of pH, reaction time, the initial concentration of Mo and W, and the influence of the amount and type ...