Cathepsin B [EC 3.4.22.1], cathepsin H [EC 3.4.22.16] and cathepsin L [EC 3.4.22.15] are the most versatile lysosomal cysteine proteases and are responsible for intracellular protein degradation. These are involved in a number of pathological conditions including tissue degenerative processes. I...

NMR Spectra of reaction products of 2,4,6-triphenylpyrylium salts with alkali cyanides, dialkylamines or alkoxides (IIIa, X = CN, NR2, OR), and hydroxylamine, hydrazine, phenylhydrazine, ammonia, or hydroxide (IVa, Y = NOH, NNH2, NNHPh, NH, O) are discussed. The latter products are possibly form...

The structure of vermeerin, a sesquiterpenoid dilactone from Geigeria africana Gries, was shown to be I. Vermeerin is the dilactone of the physiologically active vermeeric acid which causes “vomiting disease” among sheep in South Africa.

A convenient synthesis and structural characterization of (Z)- and (E)-trans-2,3-dihydro-2-methyl-3-(1,2,4-triazolyl)-4H-1-benzopyran-4-one oxime ethers has been achieved. By analysis of vicinal interproton coupling constants, it is believed that trans-2,3-dihydro-2-methyl-3-(1,2,4-triazolyl)-4H...

Bread aroma is one of the most important criteria of the quality of bakery product. Molecules exhibiting roasted notes largely contribute to this flavour and 2-acetyl-2-thiazoline (2-AT) was identified as one of the strongest. We report here the formation of its precursor 2-(1-hydroxyethyl)-4,5-...

Hydroxyperezone monoangelate (2c) was transformed into the mixture of α-(8) and β-perezols (9). Separation of these compounds permitted stereochemical assignments by NMR and ORD. The position of the angeloyl moiety in 2c was independently tested by its conversion to O-methylhydroxyperezone (1d...

IntroductionTrophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase ...

ObjectiveTo explore the underlying mechanisms of Hrd1/sema3a/IGF-1R on cardiomyocyte apoptosis.

To examine whether bucladesine sodium affects the plasma concentrations of purine bases (hypoxanthine, xanthine, and uric acid) and uridine, 100 mL of physiological saline containing bucladesine sodium (6 mg/kg weight) was administered intravenously to eight healthy subjects for 1 hour after ove...

We previously had shown that bilateral intrahippocampal infusion of 1 μg nicotine (but not 0.5 μg dose) led to an improvement in spatial memory retention in the Morris water maze task in male rats. We also reported that a similar type of bilateral infusion of H89, a protein kinase AII (PKA II)...

We previously showed that post-training intra-hippocampal infusion of nicotine–bucladesine combination enhanced spatial memory retention in the Morris water maze. Here we investigated the role of cholinergic markers in nicotine–bucladesine combination-induced memory improvement. We assessed th...

The present study shows interactive effects of pentoxifylline (PTX) as a phosphodiesterase (PDE) inhibitor, H-89 as a protein kinase A (PKA) inhibitor and bucladesine (db-cAMP) as a cAMP agonist on pentylenetetrazol (PTZ)-induced seizure in mice. Different doses of pentoxifylline (25, 50, 100 mg...

Three Hammett substituent constants for the p-phenylazo group were determined. The ionization of p-phenylazobenzoic acid in 50% ethanol gives a σp value of 0·26. The NBS bromination of p-phenylazotoluene vs toluene in benzene at 80° gives a σ+ value of −0·15. The NBS bromination of 4-phenyl...

Starting from 4-chloro- or 4-fluoroaniline, the four reaction steps — diazotization, coupling with imidazole, quaternization with dimethyl sulphate and substitution with dialkylamines, piperidine derivatives or hexamethyleneimine — were carried out as a one-pot preparation of 1,3-dimethyl-2-[4...

A piperidine-modified calix[4]arene derivative was synthesized and its structure was confirmed with X-ray diffraction data. UV–visible spectroscopy was used to study its molecular recognition of rare earth ions. The results revealed the calix[4]arene derivative could separate tight metal picrat...

The reliability in the description of the tautomerism of 1-phenylazo-4-naphthol by using of HF and MP2 ab initio levels of theory and DFT methods with variety of pure GGA (OLYP), hybrid (B3LYP and B3PW91), long range corrected (LC-BLYP) and double-hybrid (B2PLYP and mPW2PLYP) functionals with la...

6-Phenylazo-3-(p-tolyl)-2H-chromen-2-one 4 was prepared and characterized by IR, 1H, and 13C NMR spectral studies. The optimized structure of the chromen-2-one 4 was investigated by the Gaussian 03 B3LYP density functional method calculations at 6-31G(d,p) basis set. The gauge-independent atomic...

The present article deals with the synthesis, spectral characterization and antimicrobial activity of phenylazo dyes. All of the synthesized phenylazo dyes were characterized using ATR-FTIR, FT-Raman, 1H NMR, 13C NMR, elemental analysis and mass spectroscopic techniques. Solvent effects on the U...

The title compounds were prepared via the acetylated 2-bromoethyl β-glycoside (5) of α-d-Gal-(1→4)-β-d-Gal-(1→4)-β-d-GlcNAc by displacement of bromide ion with methyl 3-mercaptopropionate, octadecanethiol, and hydrogen, respectively. Silver triflate-promoted glycosylation of 2-bromoethyl 3...

The title compounds were prepared via the acetylated 2-bromoethyl glycoside 11 of α-d-Gal-(1→4)-β-d-Gal-(1→4)-β-d-Glc by displacement of bromide ion with methyl 3-mercaptopropionate, octadecanethiol, and hydrogen, respectively. Silver triflate-promoted glycosylation of 2-bromoethyl 2,3,6-tr...