Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been...

Titanium and its alloys are commonly used as dental and bone implant materials. Biomimetic coating of titanium surfaces could improve their osteoinductive properties. In this work, we have developed a novel osteogenic composite nanocoating for titanium surfaces, which provides a natural environm...

PurposeThe purpose of this study was to comparatively investigate the posterolateral fusion rate in ovariectomized (OVX) rats using two new bone graft materials: strontium (Sr) substituted hydroxyapatite (HA) nanocrystals and alendronate (AL) functionalized HA nanocrystals. SrHA was synthesized ...

Mineralized scaffolds, which are fabricated by electrodeposition, mimic the chemistry of natural bone and have attracted a great amount of attention due to their rapid and simple production. In this study, mineralized electrospun polylactic acid (PLLA) nanofibrous membranes containing different ...

This paper presents the impact of acetoacetic esters and di-carboxylic acid esters on the lubrication properties of automotive diesel. Three alkyl acetoacetates and seven di-carboxylic esters were used as lubricating additives on two low sulfur diesel fuels, at seven different concentrations of ...

Suitable conditions were sought for the synthesis of various 2-[11,14C]methyl-fatty acids by malonic ester synthesis and acetoacetic ester synthesis, both involving radio-methylation with [11,14C]Ch3I. The malonic ester synthesis gave 2-[11C]methyl-fatty acids with over 60% decay-corrected yield...

The oxidation of heavy olefins (C12–C20) was carried out using a modified Wacker system with TBHP as oxidant and acetonitrile as solvent at 80 °C. This system allowed the oxidation of 1-octadecene giving rise to 90% conversion with 60% selectivity towards 2-octadecanone after 2 h while the add...

The effect of CS2 on the performance of Ni2P/SiO2 for the deoxygenation of methyl laurate as a model compound to hydrocarbons was investigated. To explore the catalyst deactivation, the fresh and used catalysts were characterized by N2 sorption, XRD, HRTEM, 31P MAS NMR, XPS, ICP-AES and TG-DTA. ...

Poly(1-dodecene-co-pMS) copolymers were brominated by HBr/H2O2 system with high selectivity at the methyl groups of pMS units. It was found that longer reaction time, higher pMS content, and lower molecular weight of the copolymers were helpful for higher degree of bromination. Through a modifie...

Various amine nucleophiles including glycine methyl ester were used in the palladium-catalysed aminocarbonylation of (E)- and (Z)-1-iodo-1-dodecene. The substrates were synthesised from 1-dodecanal via the corresponding hydrazone, which was treated with iodine in the presence of tetramethylguani...

A series of novel 3,5-disubstituted indolin-2-ones were designed and synthesized as selective FGFR inhibitors. In the design process of 3,5-disubstituted indolin-2-ones for FGFRs, molecular docking studies were performed to generate and optimize novel compounds which have FGFR inhibitory potency...

The temperature dependence of heat capacity and characteristics of physical transformations of partially crystalline linear aliphatic polyurethanes based on 1,4-diisocyanatobutane with 1,4-butanediol and 1,6-hexanediol have been studied over the range 6.5–490 K by precision adiabatic vacuum and...

Crystallization kinetics, thermodynamics, and powder XRD measurements were performed on polyester polyols (PESP) made from succinic acid, SA, or adipic acid, AA, with 1,4-butanediol, BDO, or 1,6-hexanediol, HDO, at 2000 Da Mn. The SA BDO PESP exhibited the greatest crystallization supercooling. ...

The objective of this study was to investigate the percutaneous absorption of metronidazole (MTZ) in the topical formulations containing a combination of 1,4-cyclohexanediol and 1,2-hexanediol. Six formulations were studied in an in vitro hairless mouse skin model using Franz Diffusion Cell. MTZ...

Complexes of Cr(III) with acetoacetanilide (AAAH), acetoacet-o-toloididide (AATH), 2,4-acetoacexylidide (AAXH), acetoacet-o-chloroanilide (CAAAH), acetoacet-o-anisidide (OAAAH), benzoylacetanilide (BAAH) and benzoyl-m̄-nitroacetanilide (NBAAH) have been prepared and thiocyanated with thiocyanoge...

Qualitative tests on the reaction between chromium in its different oxidation states and pure diphenylcarbazide (DPCI), diphenylcarbazone (DPCO), and diphenylcarbadiazone are described. It is shown that the magenta-coloured complex results from the reaction of chromium(III) with diphenylcarbazon...

Pairs of geometrical isomers of octahedral cobalt(III) and chromium(III) chelates of trifluoroacetylacetone, benzoylacetylacetone and 2,2-dimethylhexane-3,5-dione can be separated by adsorption h.p.l.c. on silica. Trends in elution and required solvent systems are noted and chelate elution is su...

The vaporization enthalpies of γ-octanolactone, γ- and δ-undecanolactone and γ and δ-dodecanolactone used commercially as flavor ingredients are reported as are their vapor pressures over the temperature range T = (298.15 to 350) K. Vaporization enthalpies at T = 298.15 K of: (66.0 ± 3.9),...

On the basis of the literature data, our previous research work and docking experiments, we designed novel 19-norvitamin D compounds having elongated 2-alkylidene substituents. These 19-norcalcitriol derivatives have attached 2-(3′-aminopropylidene) substituent in which the nitrogen atom bears ...

The results presented in this paper constitute an extension of our synthetic efforts focused on 19-norvitamin D compounds possessing elongated 2-alkylidene substituents. Based on our previous results, molecular modeling studies, and docking experiments, we selected a novel 19-norcalcitriol analo...