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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Phenylbutazone manufacturer with low price

Cas:50-33-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:20°C Freezer Package:1kg/foil bag; 1kg/

Reliable manufacturer supply Phenylbutazone CAS 50-33-9 with attractive price

Cas:50-33-9

Min.Order:25 Kilogram

FOB Price: $50.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Hot sell 99% Phenylbutazone powder price CAS :50-33-9

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $29.0 / 38.7

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Phenylbutazone

Cas:50-33-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Phenylbutazone 50-33-9 GMP Manufacturer

Cas:50-33-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Phenylbutazone Manufacturer/High quality/Best price/In stock

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Phenylbutazone

Cas:50-33-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Phenylbutazon CAS: 50-33-9; 4297-92-1 English name: Phenylbutazon Chinese alias: cloth he ketone; Cloth he erected azole ding; Cloth tiger the Ann; Butyl benzene thiazole moiety; ; phenylbutazone Chemical name: 4 - bu

Phenylbutazon Manufacturer/supplier in China/High quality

Cas:50-33-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Phenylbutazone Basic information Product Name: Phenylbutazone Synonyms:

Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 50-33-9 with competitive price

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Phenyl Butazone CAS:50-33-9 MF: C19H20N2O2 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:API Transportation:By sea or by air Port:Qingdao Port

Phenyl Butazone

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

CAS NO. 50-33-9 Medicine Grade API Phenylbutazone Powder in Bulk Stock

Cas:50-33-9

Min.Order:100 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Phenylbutazone Structure: Formula: C19H20N2O2 Molecular Weight : 308.37 Synonyms: PHENYLBUTAZONE;1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline;1,2-Diphenyl-3

Factory Supply Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine 50-33-9

Cas:50-33-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply Phenylbutazone CAS 50-33-9

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $86.0 / 99.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Phenylbutazone CAS:50-33-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Phenylbutazone CAS:50-33-9

Cas:50-33-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3,5-Dioxo-1,2-diphenyl-4-N-butyl-pyrazolidin

Cas:50-33-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

bizolin bizolin 200 bunetzone butacompren 50-33-9

Cas:50-33-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Phenylbutazone CAS 50-33-9

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Phenylbutazone

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine

Cas:50-33-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Phenylbutazone

Cas:50-33-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Phenylbutazone CAS 50-33-9 with Best Price

Cas:50-33-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Phenylbutazone

Cas:50-33-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Phenylbutazone

Cas:50-33-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Phenylbutazone

Cas:50-33-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-bromo-butane
109-65-9

1-bromo-butane

1,2-diphenylpyrazolidine-3,5-dione
2652-77-9

1,2-diphenylpyrazolidine-3,5-dione

A

Phenylbutazone
50-33-9

Phenylbutazone

B

4,4-dibutyl-1,2-diphenylpyrazolidine-3,5-dione
102886-57-7

4,4-dibutyl-1,2-diphenylpyrazolidine-3,5-dione

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In hexane; acetonitrile at 55℃; for 18h; Inert atmosphere; Cooling with ice;A 85%
B 15%
1-bromo-butane
109-65-9

1-bromo-butane

1,2-diphenylpyrazolidine-3,5-dione
2652-77-9

1,2-diphenylpyrazolidine-3,5-dione

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In hexane; acetonitrile at 55℃; for 22h; Inert atmosphere; Cooling with ice;78%
With sodium hydroxide
diethyl butylmalonate
133-08-4

diethyl butylmalonate

diphenyl hydrazine
122-66-7

diphenyl hydrazine

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Stage #1: diethyl butylmalonate With sodium ethanolate In ethanol at 20℃; Inert atmosphere; Schlenk technique;
Stage #2: diphenyl hydrazine In ethanol for 24h; Reflux; Inert atmosphere; Schlenk technique;
75%
With sodium ethanolate
With sodium ethanolate
1,2-diphenylpyrazolidine-3,5-dione
2652-77-9

1,2-diphenylpyrazolidine-3,5-dione

butan-1-ol
71-36-3

butan-1-ol

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With nickel; benzene
diethyl butylmalonate
133-08-4

diethyl butylmalonate

1-acetyl-1,2-diphenylhydrazine
22293-38-5

1-acetyl-1,2-diphenylhydrazine

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With sodium ethanolate
bromo-butyl-malonyl chloride

bromo-butyl-malonyl chloride

diphenyl hydrazine
122-66-7

diphenyl hydrazine

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With diethyl ether; diethylamine
diphenyl hydrazine
122-66-7

diphenyl hydrazine

2-n-butylmalonyl dichloride
17999-54-1

2-n-butylmalonyl dichloride

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With pyridine; ethanol
hexanoic acid <N'-ethoxycarbonyl-N,N'-diphenyl-hydrazide

hexanoic acid <N'-ethoxycarbonyl-N,N'-diphenyl-hydrazide

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With sodium hydride; benzene
n-butylmalonic acid
534-59-8

n-butylmalonic acid

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether; bromine / Behandeln einer Loesung des Reaktionsprodukts in Aether mit Phosphor(V)-chlorid
2: diethyl ether; diethylamine
View Scheme
C20H23N2O6P
1229645-19-5

C20H23N2O6P

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water
2: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
disodium (4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methyl phosphate

disodium (4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methyl phosphate

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride at 37℃; pH=7.4; Kinetics; pH-value; Temperature; Reagent/catalyst; aq. buffer; Enzymatic reaction;
4-butyl-4-((methylthiomethoxy)methyl)-1,2-diphenylpyrazolidine-3,5-dione
1229521-07-6

4-butyl-4-((methylthiomethoxy)methyl)-1,2-diphenylpyrazolidine-3,5-dione

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C
3: sodium hydroxide / ethanol; water
4: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
dibenzyl ((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)methyl phosphate
1229521-08-7

dibenzyl ((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)methyl phosphate

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C
2: sodium hydroxide / ethanol; water
3: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
C21H25N2O7P
1229645-20-8

C21H25N2O7P

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water
2: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
disodium ((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)methyl phosphate

disodium ((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)methyl phosphate

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
With human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride at 37℃; pH=7.4; Kinetics; pH-value; Reagent/catalyst; Temperature; aq. buffer; Enzymatic reaction;
4-n-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-dioxopyrazolidin
23111-33-3

4-n-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-dioxopyrazolidin

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic anhydride; acetic acid / 24 h / 20 °C / Inert atmosphere
2: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C
4: sodium hydroxide / ethanol; water
5: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 0.5 h / Cooling with ice; Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / ethanol; water
3.1: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
View Scheme
diphenyl hydrazine
122-66-7

diphenyl hydrazine

Phenylbutazone
50-33-9

Phenylbutazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / chlorobenzene; mineral oil / 5 h / 0 °C / Reflux
2: potassium carbonate; sodium iodide / acetonitrile; hexane / 22 h / 55 °C / Inert atmosphere; Cooling with ice
View Scheme
Phenylbutazone
50-33-9

Phenylbutazone

4-Butyl-4-hydroxy-1,2-diphenyl-1H-pyrazol-3,5(2H,4H)-dion
16860-43-8

4-Butyl-4-hydroxy-1,2-diphenyl-1H-pyrazol-3,5(2H,4H)-dion

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydrogencarbonate In water; acetonitrile100%
With 1H-imidazole; Mn(TDCPP)Cl; dihydrogen peroxide In dichloromethane; acetonitrile at 20℃; for 4h;90%
With 3-chloro-benzenecarboperoxoic acid In ethanol for 12h; Heating;74%
Phenylbutazone
50-33-9

Phenylbutazone

phenylbutazone hydroperoxide
33053-06-4

phenylbutazone hydroperoxide

Conditions
ConditionsYield
With air; manganese triacetate In acetic acid at 23℃; for 2h;99%
With oxygen; manganese triacetate; acetic acid at 23℃; for 2h;88%
With air; di-tert-butyl peroxide In benzene for 336h; Ambient temperature;50%
sodium tetrafluoroborate
13755-29-8

sodium tetrafluoroborate

Phenylbutazone
50-33-9

Phenylbutazone

4-butyl-3,5-dichloro-1,2-diphenylpyrazolium tetrafluoroborate

4-butyl-3,5-dichloro-1,2-diphenylpyrazolium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: Phenylbutazone With trichlorophosphate In toluene for 4h; Reflux;
Stage #2: sodium tetrafluoroborate In water
99%
Phenylbutazone
50-33-9

Phenylbutazone

C18H14N2O

C18H14N2O

C37H34N4O3

C37H34N4O3

Conditions
ConditionsYield
Stage #1: C18H14N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 6h; Michael Addition; Inert atmosphere; enantioselective reaction;
98%
3-(4-bromophenyl)-1-(1-methyl-1H-imidazol-2-yl)prop-2-en-1-one

3-(4-bromophenyl)-1-(1-methyl-1H-imidazol-2-yl)prop-2-en-1-one

Phenylbutazone
50-33-9

Phenylbutazone

C32H31BrN4O3

C32H31BrN4O3

Conditions
ConditionsYield
Stage #1: 3-(4-bromophenyl)-1-(1-methyl-1H-imidazol-2-yl)prop-2-en-1-one With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 8h; Michael Addition; Inert atmosphere; enantioselective reaction;
98%
Phenylbutazone
50-33-9

Phenylbutazone

2-cinnamoyl-1-methyl-1H-imidazole
99802-91-2

2-cinnamoyl-1-methyl-1H-imidazole

C32H32N4O3

C32H32N4O3

Conditions
ConditionsYield
Stage #1: 2-cinnamoyl-1-methyl-1H-imidazole With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 6h; Reagent/catalyst; Michael Addition; Inert atmosphere; enantioselective reaction;
97%
C15H16N2O

C15H16N2O

Phenylbutazone
50-33-9

Phenylbutazone

C34H36N4O3

C34H36N4O3

Conditions
ConditionsYield
Stage #1: C15H16N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 5.5h; Michael Addition; Inert atmosphere; enantioselective reaction;
96%
C14H14N2O2

C14H14N2O2

Phenylbutazone
50-33-9

Phenylbutazone

C33H34N4O4

C33H34N4O4

Conditions
ConditionsYield
Stage #1: C14H14N2O2 With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 5h; Michael Addition; Inert atmosphere; enantioselective reaction;
96%
Phenylbutazone
50-33-9

Phenylbutazone

C11H10N2OS

C11H10N2OS

C30H30N4O3S

C30H30N4O3S

Conditions
ConditionsYield
Stage #1: C11H10N2OS With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 12h; Michael Addition; Inert atmosphere; enantioselective reaction;
96%
Phenylbutazone
50-33-9

Phenylbutazone

4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid (4-methoxy-phenyl)-amide
76383-80-7

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid (4-methoxy-phenyl)-amide

Conditions
ConditionsYield
at 150℃; for 5h;95%
Phenylbutazone
50-33-9

Phenylbutazone

1,2-diphenyl-4-n-butyl-4-fluoropyrazolidine-3,5-dione
141293-06-3

1,2-diphenyl-4-n-butyl-4-fluoropyrazolidine-3,5-dione

Conditions
ConditionsYield
With N-fluorobis<(trifluoromethyl)sulfonyl>imide In acetic acid for 0.5h; Ambient temperature;95%
Phenylbutazone
50-33-9

Phenylbutazone

C14H14N2O

C14H14N2O

C33H34N4O3

C33H34N4O3

Conditions
ConditionsYield
Stage #1: C14H14N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 7h; Michael Addition; Inert atmosphere; enantioselective reaction;
95%
Phenylbutazone
50-33-9

Phenylbutazone

C13H9F3N2O

C13H9F3N2O

C32H29F3N4O3

C32H29F3N4O3

Conditions
ConditionsYield
Stage #1: C13H9F3N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 5h; Michael Addition; Inert atmosphere; enantioselective reaction;
95%
Phenylbutazone
50-33-9

Phenylbutazone

C15H14N2O

C15H14N2O

C34H34N4O3

C34H34N4O3

Conditions
ConditionsYield
Stage #1: C15H14N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 16h; Michael Addition; Inert atmosphere; enantioselective reaction;
95%
9-hydroxyxanthene
90-46-0

9-hydroxyxanthene

Phenylbutazone
50-33-9

Phenylbutazone

1,2-Diphenyl-4-n-butyl-4-xanthen-9-yl-pyrazolidin-3,5-dion
103325-80-0

1,2-Diphenyl-4-n-butyl-4-xanthen-9-yl-pyrazolidin-3,5-dion

Conditions
ConditionsYield
With hydrogenchloride In methanol for 0.333333h; Ambient temperature;93%
Phenylbutazone
50-33-9

Phenylbutazone

p-toluidine
106-49-0

p-toluidine

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid p-tolylamide
76383-78-3

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid p-tolylamide

Conditions
ConditionsYield
at 150℃; for 5h;93%
C13H11ClN2O
128204-32-0

C13H11ClN2O

Phenylbutazone
50-33-9

Phenylbutazone

C32H31ClN4O3

C32H31ClN4O3

Conditions
ConditionsYield
Stage #1: C13H11ClN2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 8h; Michael Addition; Inert atmosphere; enantioselective reaction;
93%
Phenylbutazone
50-33-9

Phenylbutazone

2-methyl-N-(quinolin-8-yl)but‐3‐enamide

2-methyl-N-(quinolin-8-yl)but‐3‐enamide

4-(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)-2-methyl-N-(quinolin-8-yl)butanamide

4-(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)-2-methyl-N-(quinolin-8-yl)butanamide

Conditions
ConditionsYield
With palladium diacetate; acetic acid In acetonitrile at 120℃; for 4h;92%
Phenylbutazone
50-33-9

Phenylbutazone

C14H14N2O

C14H14N2O

C33H34N4O3

C33H34N4O3

Conditions
ConditionsYield
Stage #1: C14H14N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 6h; Michael Addition; Inert atmosphere; enantioselective reaction;
92%
Phenylbutazone
50-33-9

Phenylbutazone

benzylamine
100-46-9

benzylamine

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid benzylamide
76383-73-8

2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid benzylamide

Conditions
ConditionsYield
for 5h; Heating;90%
Phenylbutazone
50-33-9

Phenylbutazone

2-<3-(4-methylphenyl)acryloyl>-1-methyl-1H-imidazole
118416-05-0

2-<3-(4-methylphenyl)acryloyl>-1-methyl-1H-imidazole

C33H34N4O3

C33H34N4O3

Conditions
ConditionsYield
Stage #1: 2-<3-(4-methylphenyl)acryloyl>-1-methyl-1H-imidazole With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 5h; Michael Addition; Inert atmosphere; enantioselective reaction;
90%
Phenylbutazone
50-33-9

Phenylbutazone

3,3'-dithio-bis(4-butyl-1,2-diphenyl-5-thioxo-3-pyrazoline)
79202-01-0

3,3'-dithio-bis(4-butyl-1,2-diphenyl-5-thioxo-3-pyrazoline)

Conditions
ConditionsYield
With Lawessons reagent In toluene for 1.5h; Heating;89%
With 2,4-bis(4-methoxyphenyl)-1,3,4,2-dithiadiphosphetane In benzene at 80℃; for 3h;85%
Phenylbutazone
50-33-9

Phenylbutazone

C17H14N2O

C17H14N2O

C36H34N4O3

C36H34N4O3

Conditions
ConditionsYield
Stage #1: C17H14N2O With C38H38N4O2Rh(1+)*F6P(1-) In 1,2-dichloro-ethane at 23℃; for 0.0833333h; Michael Addition; Schlenk technique;
Stage #2: Phenylbutazone In 1,2-dichloro-ethane at 23℃; for 10h; Michael Addition; Inert atmosphere; enantioselective reaction;
89%
formaldehyd
50-00-0

formaldehyd

Phenylbutazone
50-33-9

Phenylbutazone

4-n-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-dioxopyrazolidin
23111-33-3

4-n-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-dioxopyrazolidin

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 20℃; for 24h;86%
Phenylbutazone
50-33-9

Phenylbutazone

3-nitrophenyldiazonium chloride
2028-76-4

3-nitrophenyldiazonium chloride

4-Butyl-4-(3-nitro-phenylazo)-1,2-diphenyl-pyrazolidine-3,5-dione
76383-48-7

4-Butyl-4-(3-nitro-phenylazo)-1,2-diphenyl-pyrazolidine-3,5-dione

Conditions
ConditionsYield
With sodium hydroxide In water for 2h;86%
2,4,6-tri-tert-butylphenoxyl
3315-32-0, 2525-39-5

2,4,6-tri-tert-butylphenoxyl

Phenylbutazone
50-33-9

Phenylbutazone

4-n-Butyl-4-(1,3,5-tri-tert-butyl-4-oxo-cyclohexa-2,5-dien-1-yl)-1,2-diphenyl-pyrazolidin-3,5-dion
156304-69-7

4-n-Butyl-4-(1,3,5-tri-tert-butyl-4-oxo-cyclohexa-2,5-dien-1-yl)-1,2-diphenyl-pyrazolidin-3,5-dion

Conditions
ConditionsYield
In benzene at 25℃; for 6h;85%
Phenylbutazone
50-33-9

Phenylbutazone

thiophenol
108-98-5

thiophenol

4-butyl-1,2-diphenyl-4-(phenylthio)pyrazolidine-3,5-dione

4-butyl-1,2-diphenyl-4-(phenylthio)pyrazolidine-3,5-dione

Conditions
ConditionsYield
With oxygen; potassium iodide; sodium hydroxide In acetonitrile at 80℃; under 760.051 Torr; for 24h; Green chemistry;83%
Phenylbutazone
50-33-9

Phenylbutazone

2-Methylpiperidin
109-05-7, 3000-79-1

2-Methylpiperidin

2-(2-Methyl-piperidine-1-carbonyl)-hexanoic acid N,N'-diphenyl-hydrazide
76383-74-9

2-(2-Methyl-piperidine-1-carbonyl)-hexanoic acid N,N'-diphenyl-hydrazide

Conditions
ConditionsYield
at 150℃; for 5h;81%
Phenylbutazone
50-33-9

Phenylbutazone

[bromo(difluoro)methyl](trimethyl)silane
115262-01-6

[bromo(difluoro)methyl](trimethyl)silane

A

C20H20F2N2O2

C20H20F2N2O2

B

4-butyl-4-(difluoromethyl)-1,2-diphenylpyrazolidine-3,5-dione

4-butyl-4-(difluoromethyl)-1,2-diphenylpyrazolidine-3,5-dione

Conditions
ConditionsYield
Stage #1: Phenylbutazone With lithium iodide; sodium t-butanolate In dichloromethane at 20℃; for 0.166667h; Schlenk technique; Glovebox; Inert atmosphere;
Stage #2: [bromo(difluoro)methyl]-trimethyl-silane In dichloromethane at 20℃; for 0.5h; Temperature; Schlenk technique; Glovebox; Inert atmosphere; regioselective reaction;
A n/a
B 81%
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