AimsIn the present study we investigated the intervention of nitric oxide and prostacyclin in the responses to vasopressin of isolated thyroid arteries obtained from multi-organ donors.

The present work demonstrates the utility of the extended DFT-derived scaled quantum mechanical (SQM) force fields for predicting the product of a chemical synthesis, namely the reaction of 1,3-dihydrobenzimidazol-2-one with BSTFA [N,O-bis(trimethylsilyl)trifluoro-acetamid]. Since the reactant h...

A potent, orally available dual CysLT1 and CysLT2 receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC50: CysLT1 = 13 nM, CysLT2 = 25 nM) showed excellent pharmacokinetic profil...

In the present study, a series of 1-ethyl/benzyl-6-fluoro-7-(substituted piperazin-1-yl)1,4-dihydro-4-oxo-quinoline-3-carboxylic acid were synthesized and characterized by IR, 1H-NMR, mass spectral and elemental analysis. The in vitro antibacterial and antifungal activities of the compounds were...

2-Oxo-2H-chromenylpyrazolecarboxylates (8a–h and 12a–zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a–h and 11a–w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H)-ones (13i–n) were prepared from corresponding phenylhydrazones (7...

In the present communication, a new series of 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids (2a–p) have been synthesized. Benzaldehyde 4-phenyl-3-thiosemicarbazones substituted (1a–p) were also obtained and used as intermediate to give the title compounds. All synthe...

In the present study, a novel pre-miniproinsulin analogue was designed to have a short 9 residue sequence replacing the 35 residue C-chain, one lysine and one arginine added to the C-terminus of the B-chain in combination with glycine and arginine substitution at A21 and B29, respectively, and a...

Several HNO3-based leaching approaches were tested and optimized to selectively recover Pb and other minor metals (Cu, Ni, Zn) from secondary lead smelter residues (i.e., slag and matte). Firstly, the leaching behaviors of Pb and the matrix element Fe were studied at atmospheric pressure in the ...

Using 4 inferior residual oils as raw materials, the effect of feedstock properties on the characteristics of coke formation during initial thermal conversion process was studied. The results show that the influence for coke induction period of different oils affected by temperature can be measu...

The investigation of organic residues associated with archaeological pottery using modern analytical chemical methods began in the 1970s. It was recognised early on that the analysis of lipids (i.e. fats, waxes and resins) preserved in surface residues or the fabric of single potsherds, represen...

We investigated the effect of prohexadione-calcium (Pro-Ca) on growth characteristics and endogenous gibberellins content of Chinese cabbage grown in the alpine region of South Korea. Pro-Ca was applied at the rates of 200 ppm and 400 ppm, after 10, 15 and 20 days of transplanting seedlings in t...

Different studies describing Prohexadione calcium (P-Ca) as an efficient tool to reduce shoot growth have been extensively reported, but these studies are usually performed in typical temperate climate regions. However, a complete analysis of the effects of P-Ca in pear trees in regions of warm-...

‘Northern Spy’ apple trees have a relatively long non-fruiting period following planting, which reduces their economic feasibility of production. Previous work supporting the benefits of ethephon (ETH) for enhancing flowering precocity on bearing apple trees was the impetus behind the present ...

Hops (Humulus lupulus), a main ingredient in beer, are valued as a source of bitter flavour and biologically active polyphenols. We treated immature hop cones with prohexadione-calcium (Pro-Ca), a flavanone-3-hydroxylase (F3H) inhibitor, to perturb the flavonoid pathway, and conducted a targeted...

Sweet orange (Citrus sinensis L. Osbeck) cv. ‘M7’ Navel exhibits poor flavedo colour at harvest in Western Australia. Gibberellins are known to retard fruit colour development in citrus fruit, therefore the efficacy of different concentrations and timings of spray applications of two inhibitor...

A wide range of agrochemicals can be applied in a peanut production system to control various stresses and manage crop growth and development. Field and laboratory experiments were conducted in North Carolina to define biological and physicochemical interactions when insecticides (fenpropathrin ...

Antimicrobial resistance among Gram-negative bacteria is a growing problem, fueled by the paucity of new antibiotics that target these microorganisms. One novel family of macrocyclic β-hairpin-shaped peptidomimetics was recently shown to act specifically against Pseudomonas spp. by a novel mech...

A practical synthetic route for the asymmetric synthesis of β2-amino acids is described. In the first step, the procedure involves the N-acylation of readily available, enantiopure hexahydrobenzoxazolidinone (4R,5R)-1 with 3-methylbutanoyl chloride 2, 4-methylpentanoic acid 3, and 3-(1-tert-but...

A Rh2(OAc)4 and InCl3 co-catalyzed three component reaction of diazo compounds, carbamates and aldehydes has been developed to synthesize β-hydroxyl-α-amino acid derivatives in good yields with excellent diastereoselectivity. The reaction is proceeded via trapping of active carbamate ammonium ...

Targeting tumor vasculature represents an intriguing therapeutic strategy in the treatment of cancer. In an effort to discover new vascular disrupting agents with improved water solubility and potentially greater bioavailability, various amino acid prodrug conjugates (AAPCs) of potent amino comb...