Reaction of Boc-Glu-Thr-Ile-His-OMe (Boc: butoxy carbonyl) (H21), and Zn(ClO4)2·6H2O in N,N-dimethylformamide (DMF) was studied using NMR and mass spectrometry with respect to the active sites of proteases. The study of H21/Zn2+ = 1:1 mixture in DMF-d7 revealed that Zn2+ is bound to the His-imi...

A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 7a–i were synthesized and evaluated as novel acetylcholinesterase (AChE) inhibitors. All target compounds were evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Compound 7c showed an excell...

The solubility of 2,4-dihydro-5-methyl-2-(4-methylphenyl)-3H-pyrazol-3-one in twelve organic solvents including methanol, ethanol, n-propanol, isopropanol, ethylbenzene, toluene, n-butanol, acetonitrile, ethyl acetate, 1,4-dioxane, cyclohexane and isopentanol were determined experimentally by us...

Oxidations of hydrazine (H2NNH2) and substituted hydrazines (t-C4H9HNNH2 and c-C6H11HNNH2) by [IrCl6]2− are found to obey overall second-order kinetics: −d[IrCl62−]/dt = k′[RHNNH2]tot[IrCl62−], where k′ pertains to the observed second-order rate constants and [RHNNH2]tot stands for the total c...

A kind of less platinum hydrogen evolution reaction (HER) catalyst, 3%Pt/WC/C10, is successfully synthesized using a simple in-situ platinum reduction method of directly mixing WC/C10 and chloroplatinic acid in deionized water and then drying. The structure and morphology are mainly characterize...

A comparison is reported between the products formed by the (n, α) reaction in hydrated and anhydrous sodium hexachloroiridate (IV), as well as in the ammonium salt. The effects of hydration and dehydration after the neutron irradiation are also described. The results show that both water of hy...

Unlike other noble metals, iridium is not precipitated from neutral or mildly acidic solution by the action of borohydride. However, quantitative precipitation as a mixture of iridium metal and iridium(IV) hydroxide can be achieved by the use of sodium tetrahydroborate at pH 8–10. The rate of t...

The present study reports findings regarding the contrast between H2S interaction with bovine hemoglobin (Hb) and horse heart myoglobin (Mb), in terms of binding and dissociation kinetics, affinities, and mechanism. At pH 9.5, oxidation of ferric-sulfide adducts in presence of no free sulfide, u...

Reaction of guaiazulene (1) with thiophene-2,5-dicarbaldehyde (2) in methanol in the presence of hexafluorophosphoric acid at 25 °C for 3 h gives as high as 90% isolated yield of the delocalized dicarbenium-ion compound, 2,5-thienylenebis(3-guaiazulenylmethylium) bis(hexafluorophosphate) (3). S...

Reactions of guaiazulene (1) with heteroaromatic-carbaldehydes [i.e., 2-furaldehyde (2), thiophene-2-carbaldehyde (3) and pyrrole-2-carbaldehyde (4)] in methanol in the presence of hexafluorophosphoric acid at 25 °C for 30 min under aerobic conditions give (2-furyl)(3-guaiazulenyl)methylium hex...

Reaction of guaiazulene (1) with o-formylbenzoic acid (2) in diethyl ether in the presence of hexafluorophosphoric acid at 25 °C for 90 min gives the corresponding monocarbenium-ion compound, [2-(carboxy)phenyl](3-guaiazulenyl)methylium hexafluorophosphate (3), quantitatively, which upon treatm...

In contrast to other chemical reducing agents, it has been found that sodium trimethoxyborohydride will selectively reduce 1-chloro-2-iodoperfluorocycloalkenes to give good yields of 1-hydro-2-chloroperfluorocycloalkenes. The selective displacement of iodine by hydrogen is discussed in terms of ...

The properties of the lowest excited states of EE-1-phenyl,4-(1′-pyrenyl)-1,3-butadiene were studied by absorption and emission spectrometry in solvents of different polarity and polarizability. The effect of the latter on the energy and relative position of the two lowest excited singlet state...

Reaction of aldehydes with 1-lithio-1,3-butadiene reagents possessing a methyl substituent, a phenyl substituent or a hydrogen at position 4 of the butadienyl skeletons was studied. Polysubstituted cyclopentadiene derivatives were obtained in high yields upon hydrolysis using strong acidic solut...

Reaction of ferrocenecarbaldehyde with benzyltriphenylphosphorane and (E)-Cinnamyltriphenylphosphorane, respectively, afforded (E)- and (Z)-1-ferrocenyl-2-phenylethene ([(E)-5] and ([(Z)-5]), and (1E,3E)- and (1Z,3E)-1-ferrocenyl-4-phenyl-1,3-butadiene ([(1E,3E)-6] and [(1Z,3E)-6]), respectively...

A naphthoquinone inhibitor of human arylamine N-acetyltransferase 1 (hNAT1), a potential cancer biomarker and therapeutic target, has been reported which undergoes a distinctive concomitant color change from red to blue upon binding to the enzyme. Here we describe the use of in silico modeling a...

Multifunctional 2-aminobenzimidazoles were directly synthesized through sequential addition of N-substituted o-diaminoarenes to isothiocyanates, formation of carbodiimides via I2-mediated oxidative desulfurization, and intramolecular cycloaddition. This efficient and eco-friendly synthetic proce...

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide (T0901317, 6) is a potent activator of pregnane-X-receptor (PXR), which is a nuclear receptor controlling P-gp expression. Herein, we aimed to investigate P-gp induction activity of T0901...

The standard (p∘=0.1MPa) massic energy of combustion, in oxygen, of the crystalline 3-acetyl-2-methyl-5-phenylthiophene was measured, at T = 298.15 K, by rotating-bomb combustion calorimetry, from which the standard molar enthalpy of formation, in the condensed phase, was calculated as ΔfHm∘(...

The synthesis of D-valine has been optimized starting from isobutyraldehyde, sodium cyanide and ammonium carbonate. The intermediate hydantoin was converted by a bienzymatic system to D-valine.The specific consumption of Agrobacterium radiobacter resting cells, which are high producers of hydant...