An environment benign process has been developed for the regioselective synthesis of 5-iodo-1,4-disubstituted-1,2,3-triazoles catalyzed by CuI/β-CD in water. Moreover, the process was manifested for the efficient synthesis of 2-iodo-imidazo[1,2-a]pyridines and 2-iodo-benzoimidazo[2,1-b]thiazole...

The free fatty acid receptor 1 (FFA1) plays an important role in amplifying insulin secretion in a glucose dependent manner. We have previously reported a series of FFA1 agonists with thiazole scaffold exemplified by compound 1, and identified a small hydrophobic subpocket partially occupied by ...

New series of furan–thiazole hybrids (3a-f), thiazolo[2,3-c]-1,2,4-triazines (4a-f), their bioisosteres 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazines (8a-d) and 1,2,4-triazino[4,3-b]-1,2,4-triazines (13a-e) were designed, synthesized and evaluated for their in vitro antitumor activities at the Natio...

IQS has been proven to be a new quorum sensing (QS) system against bacterial biofilm formation, which is activated in the common phosphate-limiting environment of infected tissues taking over the central las system. Up to now, numerous biofilm inhibitors which function by affecting traditional Q...

Organic compounds containing five-membered aromatic heterocyclic rings play an important role in life science. Among them thiazole and isothiazole heterocycles are present in many pharmaceutical drugs and crop protection compounds and have sparked over past years an enormous interest on these sc...

New fluorescent dyes derivatized on a classical thiazole orange framework are able to show unexpectedly strong interaction signal and unusual binding selectivity with different structures of nucleic acid, particularly when bound with double-stranded DNA or G-quadruplex DNA. The present study rev...

Inhibition of 5α-reductase and anti-androgenicity were studied in rats treated with various 4-azasteroids. The known inhibitor, N,N-diethyl-4-methyl-3-oxo-4-aza-5 α-androstane-17 β-carboxamide (4-MA) served as a reference compound, and analogs of this basic molecule were assayed. Enhancement ...

BackgroundThis study investigated the safety and efficacy of famciclovir compared to acyclovir in patients with herpes zoster, to determine whether the two regimens are equally effective for the treatment of patients with uncomplicated herpes zoster over a period of 7 days.

Xanthoceras sorbifolia Bunge seed oils are suitable for broad nutritional and bio-functional purposes. In this study, the oil yield, physicochemical properties, fatty acid profile, Fourier transform infrared spectra, tocopherol content, antioxidant activity, oxidative and thermal stability, and ...

Potyvirus is the largest genus of plant viruses that causes significant losses in a wide range of crops. Potyviruses are transmitted through aphids, and the helper component proteinase (HC-Pro) of the virus is required for transmission. However, HC-Pro is a multifunctional protein that has self-...

Being lack of core data and measured data, although the marine oil & gas exploration in the South Yellow Sea Basin has been going on for 57 years, no commercial hydrocarbon reservoirs have been found so far. The quantitative source rocks evaluation based on geochemical data and fluid inclusions ...

The interactions of microbiota in the intestines play an important role in promoting or maintaining the health of hosts. The present study aim to investigate the effects of the surface proteins of Lactobacillus pentosus HC-2 on the immune response and the bacterial composition of Litopenaeus van...

A novel fluorescence chemical sensor for the highly sensitive and selective determination of Pb2+ ions in aqueous solutions is described. The preliminary potentiometric and spectrofluorimetric complexation studies in solution revealed that the lipophilic ligand 5,8-bis((5′-chloro-8′-hydroxy-7′...

The enzyme tyrosinase plays a vital role in melanin biosynthesis and enzymatic browning of vegetables and fruits. A series of novel quinolinyl thiourea analogues (11a-j) were synthesized by reaction of 3-aminoquinoline and corresponding isothiocyanates, in moderate to excellent yields with diffe...

Streptococcus agalactiae is a Gram-positive pathogen that can survive inside professional phagocytes and nonphagocytic cells to cause septicemia and meningoencephalitis in freshwater and marine fish. However, vaccines based on extracellular products (ECP) and formalin-killed whole S. agalactiae ...

Microbial oxidation of antimonite [Sb(III)] to antimonate [Sb(V)] is a detoxification process which contributes to Sb(III) resistance. Antimonite oxidase AnoA is essential for Sb(III) oxidation, however, the regulation mechanism is still unknown. Recently, we found that the expressions of phosph...

Burn wounds which require skin grafts are often heavily contaminated. Conventional methods of skin grafting demand bulky dressings and immobilization for 3–5 days. During this period, we cannot treat the wound topically, but can only hope that the skin graft will win the battle against infectio...

As a temporary dressing on scald wounds in children Omiderm was tried in 10 consecutive patients. Omiderm is a thin, transparent, hydrophilic polyurethane membrane, permeable to water and oxygen. It was applied on the wound when exudation was declining, about 4–10 hours postburn. The dressing f...

In the search for a good temporary donor site dressing two synthetic products were compared in a randomized controlled clinical trial: Duoderm, a double layer dressing with an inner hydrocolloid polymer complex layer and an outer layer of polyurethane foam, impermeable to water and oxygen, and O...

This article reports a method that is used for the preconcentration and determination of Cd2+ and Co2+ in vegetables, using Pleurotus eryngii immobilized Amberlite XAD-16 as a solid-phase biosorbent. The concentrations of metals were determined by inductively coupled plasma-optical spectrometry ...