Surface functionalization of Ag nanocubes and nanoparticles with catalytically active ruthenium carbonyl oligomers has been carried out successfully. These functionalized nanostructures catalyze hydrocarboxylation onto terminal alkynes at significantly enhanced rates (33 times) compare to those ...

Two aryl-thiolato-bridged ruthenium carbonyl chloro clusters were synthesized from reactions of [Ru(CO)2(μ-Cl)2]n and sodium arylthiols. The tetra- and hexa-nuclear clusters display unique eight and twelve metallomacrocycle rings with Ru4S4 and Ru6S6 cores, respectively.

The acetylene [Ru3(μ-CO)(CO)9{µ3-η2-(//)HCCR}] (1a: R = C(Me)CH2); 1b: and the acetylide [Ru3(µ-H)(CO)9{µ3-η2-(⊥)CCR}] (2a: R = C(Me)CH2; 2b: clusters have been synthesized from the reaction of [Ru3(CO)10(NCMe)2] with 2-methyl-1-buten-3-yne and 1-ethynylcyclohexene respectively. The rea...

The methyl CH bonds in the dimethylfulvene complex [η5,η1-C5H4C(CH3)2][Ru(CO)2][Ru(CO)4] are known experimentally to be activated by the central Ru2 unit to give the dehydrogenation product [η5,η3-C5H4C(CH2)2][Ru(CO)2][Ru(CO)3]. The mechanistic aspects of this process are explored by a theor...

Four new triruthenium carbonyl containing 4-pyrones: Ru3(CO)8(2 L-2H) 1 (L = ethylmaltol), Ru3(CO)7(PTA) (2 L-2H) 2 (L = ethylmaltol, PTA = 1,3,5 triaza-7-phosphaadamantane), Ru3(CO)8(2 L-2H) 3 (L = allomaltol), Ru3(CO)7(PTA) (2 L-2H) 4 (L = allomaltol, PTA = 1,3,5 triaza-7-phosphaadamantane) ha...

The interest in therapeutical applications of carbon monoxide to physiological targets has led us to explore CO releasing molecules (CORM’s), particularly those that decomposes upon a specific stimuli, i.e. light irradiation. Here, we prepared a photoactivated, air stable and water soluble ruth...

The aerobic oxidation of the binuclear ruthenium(0) carbonyl complexes [Ru2(CO)5(μ-dppm)2], dppm = Ph2PCH2PPh2, 1, and [Ru2(μ-H) (CO)5(μ-dppm)2]+X−, 2, has been studied. In acidic solution a 4-electron oxidation of 2 occurs to give [Ru2(μ-OH)2CO)4(μ-dppm)2]X2, X = ReO4 or BF4. However, in n...

The reactions of pyridine alcohols PyCH2CH(Ar)OH [Ar = Ph (1), 4-CH3C6H4 (2), 4-ClC6H4 (3)], and PyCH2C(CH3)2OH (4) with Ru3(CO)12 in refluxing toluene gave a series of ruthenium carbonyl complexes PyCH = C(Ph)O][PyCH = C(Ph))Ru(CO)2 (5) and [PyCH2CH(Ph)O]2Ru3(CO)8 (6), [PyCH = C(4-CH3C6H4)O]2Ru...

The treatment of 2-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)pyridine (HL1) and PhICl2 as halogenation reagent generated monochloro-pyrrole HL2, dichloro-pyrrole HL3 and penta-chloro L4. The reaction of HL3 with [Ru(CO)2Cl2]n gave diruthenium(I) complex [Ru2(μ-κ2N,N′:κ1N″-L3)2(CO)4] (1) and monoruth...

Fluorinated iodoacetate (CF3)2CFCH2CHICH2OAc (1) (prepared by radical addition of perfluoroisopropyl iodide to allyl acetate) and fluorinated iodohydrin (CF3)2CFCH2CHICH2OH (2) (prepared from 1) were converted to the corresponding perfluoroalkylated oxirane (CF3)2CFCH2CH(O)CH2 (3) in the yie...

A copper (II) compound with 1,10-phenanthroline (C12H10N2, phen) and salicylate (C7H5O3, Hsal), formulated as [Cu(phen) (Hsal)2(H2O)] or compound (1), has been simply synthesized and characterized. Single crystal X-ray diffraction revealed a neutral pentacoordination compound with one of salicyl...

Salicylate release from a microstructured polypyrrole coating with a large surface area was investigated. The drug was incorporated as a dopant in the polymer matrix via electropolymerization of pyrrole in a simple one-step process. The influence of several parameters such as applied potential a...

The effectiveness of analogs of lithocholic acid and other bile acids in inhibiting glucuronosyltransferase activity in a colon cancer cell line was measured in order to identify structural features critical for inhibition of the enzyme. Analogs of lithocholic acid with modifications of the side...

Cobalt-catalyzed iodosulfonylation of alkynes can be achieved using sodium sulfinates in the presence of KI. This procedure produces numerous stereoselective (E)-β-iodoalkenyl sulfones with good yields and suppresses the formation of diiodoalkenes. Furthermore, when this reaction is performed i...

Inspired by the active site structure of Co-HPCD (HPCD = homoprotocatechuate 2,3-dioxygenase), in which the catechol binds to the cobalt(II) center in its monoanionic form in a bidentate fashion, we report the synthesis and characterization of [PhTttBu]Co(3,5-DBCatH) [PhTttBu = phenyltris(tertbu...

A divalent cobalt iodine complex bearing 1,3-bis(mesityl)imidazol-2-ylidene and pyridine ligands was synthesized and its structure was determined. The cobalt center has a typical d7-tetrahedral geometry, as expected. Catalytic application of this cobalt complex with bromoalkanes and Grignard rea...

Methodology for the preparation of rat and human pancreatic lipase (EC 3.1.1.3) is described, which resulted in good yield of partially purified, stable enzyme useful for kinetic studies. Apparent Km values for the rat (6.5 mM) and human (3.5 mM) enzyme were determined with triolein as the subst...

A novel synthetic approach towards α-trifluoromethyl-phenethylamines was elaborated by reduction of the electron deficient β-aryl-α-trifluoromethyl enamines and imines with sodium cyanoborohydride in the presence of trifluoroacetic acid. The starting imines were prepared by the reaction of pr...

Catalytic ring hydrogenation of 1- and 2-phenylethanols was studied over several noble metal catalysts supported on charcoal or γ-alumina in supercritical carbon dioxide. The major products formed were corresponding cyclohexylethanols via aromatic ring hydrogenation of 1- and 2-phenylethanols w...

Magnetic Fe3O4 nanoparticles as a support were modified with an amino-terminated organosilicon and cyanoric choloride ligands. The novel manganese complex was grafted on modified magnetic support (Mn(II)[email protected]). The nanocatalyst structure, particle size, morphology and surface propert...