Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Their in vivo anticonvulsant screenings were performed by two most adopted ...

Military aircraft retirements are an afterthought for many lifecycle planners. More active management of end-of-life fleets can yield increased confidence in fleet capability and retirement timelines. This work provides fleet managers with a tool to manage remaining aircraft flight hours to yiel...

Glycyrrhetinic acid has been usually studied for their anti-tumor activities. However, the low bioavailability and poor aqueous solubility as well as limited intracellular accumulation have limited their utility. In this present study, a series of new glycyrrhetinic acid conjugates with a triphe...

ObjectivesPrompt identification of necrosis and apoptosis in the infarct core and penumbra region is critical in acute stroke for delineating the underlying ischemic/reperfusion molecular pathologic events and defining therapeutic alternatives. The objective of this study was to investigate the ...

Effects of the lanthionine-containing peptide antibiotics duramycin, duramycin B, duramycin C and cinnamycin on the activity of phospholipase A2 from six different sources were studied, and their mode of action was investigated. The four antibiotics inhibited potently all tested phospholipases A...

When pathologically externalized, phosphatidylethanolamine (PE) is a potential surrogate marker for detecting tissue injuries. 99mTc-labeled duramycin is a peptide-based imaging agent that binds PE with high affinity and specificity. The goal of the current study was to investigate the clearance...

Introduction99mTc-Duramycin is a unique radiopharmaceutical that binds specifically to phosphatidylethanolamine (PE). The current effort is to develop a single-step kit formulation for the 99mTc labeling of HYNIC-Duramycin.

Introduction99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between 99mTc-Duramycin and the target tissue.

ObjectivesThe purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m (99mTc)-labeled Duramycin, and compare it to an established tracer, 99mTc-labeled Annexin-V, which has a relative disadvantage of high radiation b...

Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through delivery of a photosensitising agent and light irra...

Apoptosis of macrophages and smooth muscle cells is linked to atherosclerotic plaque destabilization. The apoptotic cascade leads to exposure of phosphatidylethanolamine (PE) on the outer leaflet of the cell membrane, thereby making apoptosis detectable using probes targeting PE. The objective o...

Introduction[99mTc]duramycin is a SPECT tracer for cell death imaging. We evaluated the impact of kit formulation, purification and species difference on the pharmacokinetic profile and cell death targeting properties of [99mTc]duramycin in order to define the optimal conditions for (pre-)clinic...

ObjectiveApoptosis plays a crucial role in many biological processes, especially in cancer. However, real-time monitoring of apoptosis is challenging. [99mTc]duramycin can selectively target an apoptosis biomarker: phosphatidylethanolamine (PE), which is normally located on the intracellular cel...

Publisher SummaryThis chapter discusses those drugs where one or more photoderivatives have been positively identified and photosensitizers which, although unchanged themselves, photocatalyse the degradations of biomolecules. Precautions against the photodegradation of drugs in storage are easil...

An efficient method is reported to reduce aromatic ketones selectively into arylmethylenes or alcohols with hypophosphites and Pd/C, depending on the selected conditions. This study could represent a promising alternative to the classical uses of standard hydrides or molecular hydrogen involved ...

Polymer supported transition metal complexes of N,N′-bis (o-hydroxy acetophenone) hydrazine (HPHZ) Schiff base were prepared by anchoring its amino derivative Schiff base (AHPHZ) on cross-linked (6 wt%) polymer beads and then loading iron(III), copper(II) and zinc(II) ions in methanol. The load...

Phenol and its derivatives (alkylphenols, halogenated phenols, nitrophenols) are natural or man-made aromatic compounds that are ubiquitous in nature and in human-polluted environments. Many of these substances are toxic and/or suspected of mutagenic, carcinogenic, and teratogenic effects. Biore...

In this study, microwave assisted pyrolysis of waste printed circuit boards (PCBs) using carbonaceous susceptors like graphite and activated carbon was conducted to devise an efficient technique to treat the electronic wastes. Pyrolysis experiments were conducted in a batch microwave reactor, an...

In this study, the potential applicability of potassium permanganate (Mn(VII)) for anilines elimination was systematically investigated firstly, with a focus on the effect of manganese intermediates on the kinetics of anilines versus phenols. It was found that Mn(VII) could fairly oxidize anilin...

The reactions of a monomeric N-halamine, 1-chloro-5,5–dimethylhydantoin (MCDMH), and a mesoporous material-supported N-halamine (MMSNs) with phenol and p-cresol (two common contaminants in water) were investigated. MCDMH reacted rapidly with the phenolic compounds, and pH values had little effe...