A novel tetradentate Cu(II) complex of the type, [CuL](NO3)2 was synthesized by the interaction of Schiff base ligand, N,N-bis[(E)-2-thienylmethylidene]-1,8-naphthalenediamine, L obtained by the condensation of thiophene-2-carboxaldehyde and 1,8-diaminonaphthalene. The formation of Schiff base l...

The molecular geometry, vibrational frequencies and gauge including atomic orbital (GIAO) 1H NMR chemical shift values of the title molecule, N,N′-bis-(4-hydroxy-α-methylsalicylidene)ethylenediamine nickel(II) complex, (C18H18N2NiO4) in the ground state have been calculated using density funct...

2-Mercapto-3-methyl-1-butanol (2M3MB) imparts an onion-like off-flavor to beer and is believed to result from the hot aeration of brewer’s wort. However, little has been reported regarding the mechanism of formation of 2M3MB. This paper investigates the precursors of 2M3MB formed during the bre...

We have studied the effect of cavitating ultrasound on the heterogeneous aqueous hydrogenation of cis-2-buten-1-ol (C4 olefin) and cis-2-penten-1-ol (C5 olefin) on Pd-black to form the trans-olefins (trans-2-buten-1-ol and trans-2-penten-1-ol) and saturated alcohols (1-butanol and 1-pentanol, re...

The reaction of Zn-protected (Z)-3-iodo-2-buten-1-ol with organozincs in the presence of 1–5 mol% of a Pd complex, e.g., Pd(PPh3)4 or Cl2Pd(PPh3)2 and n-BuLi (2 equiv), in DMF provides a highly stereoselective (> -96%), general, and high-yielding procedure for preparing (Z)-3-methyl-2-alken-1-o...

a synthetic method for the preparation of the acetate of (Z)-4-chloro-2-methyl-2-buten-1-ol, a precursor of the (Z)-hydroxy prenyl synthon is described. The use of such synthon in the preparation of a metabolite of a prenyl-containing substance is also illustrated.

Acid-catalyzed heterogeneous oxidation with hydrogen peroxide (H2O2) has been suggested to be a potential pathway for secondary organic aerosol (SOA) formation from isoprene and its oxidation products. However, knowledge of the chemical mechanism and kinetics for this process is still incomplete...

Publisher SummaryThis chapter discusses the action of lead tetraacetate on the sugars. Lead tetraacetate appears to have been first used as an organic oxidant in place of established reagents as the dioxides of manganese and lead. With the discovery of the cleavage of glycols by lead tetra-aceta...

Farnesal and 3-hydroxy-2,3-dihydrofarnesal (3-hydroxy-3,7,11-trimcthyl-6,10-dodecadiene-1-al) were formed from farnesol when the alcohol was incubated with the protoplast of Botryococcus braunii B race strain. This fact suggests the existence of farnesal hydratase in the alga. Feeding experiment...

The juvenile hormones (JHs) play a central role in insect reproduction, development and behavior. Interrupting JH biosynthesis has long been considered a promising strategy for the development of target-specific insecticides. Using a combination of RNAi, in vivo and in vitro studies we character...

Parallel-stranded oligonucleotides containing 5-methylisocytosine-guanine and/or isoguanine-cytosine base pairs were prepared. The coupling efficiency was higher than 99% when the phosphoramidites of 2′-deoxy-5-methylisocytidine (2a) and of 2′-deoxyisoguanosine (3) were employed in solid-phase...

2′-Deoxy-5-methylisocytidine is widely used in assays to personalize the care of patients infected with HIV, hepatitis C, and other infectious agents. However, oligonucleotides that incorporate 2′-deoxy-5-methylisocytidine are expensive, because of its intrinsic chemical instability. We report...

The steroids 7α,17β-dihydroxy-5α-androstan-3-one (7α-hydroxy-Dht), 5α-androstan-3α,7α,17β-triol (7α-hydroxy-3α-A'DIOL) and 5α-androstane-3β,7α,17β-triol (7α-hydroxy-3β-A'DIOL) have been synthetized from 7α,17β-dihydroxy-4-androsten-3-one (7α-hydroxy-testosterone). Th...

From incubations of testosterone with rat testicular homogenates in the presence of a NADPH-generating system, the following 7α-hydroxylated metabolites could be isolated and identified: 7α,17β-dihydroxy-4-androsten-3-one (7α-hydroxy-testosterone), 7α-17β-dihydroxy-5α-androstan-3-one (7α...

SummaryN-hydroxyphenacetin, a phenacetin metabolite, was fed to rats as a 0.05–0.5% dietary supplement. After 9 months, tumours of the liver were found in 36 of 64 animals. One animal also developed a renal tumour. No tumours were found in control animals. The findings implicate phenacetin as a...

N-Hydroxyphenacetin on acid treatment or after N-ester formation will react with methionine viaN-acetyl-p-benzoquinoneimine (VI) to give 4-hydroxy-3-methyl-thioacetanilide, a new urinary metabolite of phenacetin.

High pressure liquid chromatography and gas chromatography-mass spectrometry revealed that hamster liver microsomes form N-hydroxyacetaminophen from N-hydroxyphenacetin but apparently not from acetaminophen. Nevertheless more covalent binding of radiolabel occured with 3H-acetaminophen as a subs...

BackgroundHuman cytomegalovirus (HCMV) is a common pathogen that causes many diseases in young children. HCMV glycoprotein H (gH) genotypes may be associated with the type and severity of some diseases. In this study, systematic surveillance was conducted on the prevalence of HCMV infections and...

The activity of 6-hydroxymellein (6HM) synthase, a multifunctional polyketide biosynthetic enzyme in carrot, was appreciably inhibited in the presence of ATP: citrate lyase, a CoA-scavenging enzyme. Catalytic rate of the synthase markedly decreased when deuterium-labeled NADPH was employed in th...

6-Hydroxymellein (6HM) synthase is a multifunctional polyketide enzyme induced in carrot cells, whose fully active homodimer catalyzes condensation of acyl-CoAs and the NADPH-dependent ketoreduction of the enzyme-bound intermediate. 6HM-forming activity of the synthase was markedly decreased whe...