Heme oxygenase 1 (HO-1) is the first and rate-controlling enzyme in heme degradation. Bach1 is a mammalian transcriptional repressor of HO-1. To understand how zinc mesoporphyrin (ZnMP) induces the expression of HO-1, we investigated the effects of ZnMP on Bach1 mRNA and protein levels in human ...

Attraction of the German cockroach, Blattella germanica, to esters was tested in a heavily infested room. Sticky traps of cardboard baited with hexyl hexanoate and pentanoate captured higher numbers than an empty control. Recluction or extension of the alcohol moiety even by a C1 unit resulted i...

Effects of modifications including ring unsaturation on the activity of propyl cyclohexaneacetate to attract the German cockroach were comparatively tested in field conditions. The test compounds were arranged in the decreasing order of activity as follows: propylcyclohexaneacetate > propyl 3-cy...

Propyl cyclohexaneacetate, a synthetic attractant to the German cockroach, Blattella germanica, appears to consist of a head (cyclohexane ring) and a tail (ester linkage). The tail was modified as regards a number of structural parameters, and the change in activity was interpreted in terms of t...

Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate fun...

The syntheses and stereochemistry of two new amino acids obtained from the monoterpene ketones (−)-cis-caran-trans-4-one and (−)-menthone via appropriate lactams are presented. The configuration of all stereogenic centers is confirmed by X-ray crystallography.

Fluorine-18 labeled analogs of 8-fluorooctanoic acid and its structurally modified derivatives with methyl or gem-dimethyl branching or with oxygen substitution at the C3 position were prepared using nucleophilic substitution of the tosylate precursors by [18F]fluoride ion, for evaluation as tra...

The dynamic coagulation of colloidal pitch was quantified under orthokinetic conditions. The effects of single salt, multiple salt and cation valency on the stability of the colloidal pitch were investigated as a function of salt concentration. Critical coagulation concentrations (CCCs) were det...

Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those o...

A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less a...

The thermal decomposition of abietic acid in air was investigated under non-isothermal condition using thermogravimetric analysis-differential thermal analysis (TGA-DTA) technique with heating rates of 5, 10, 15 and 25 K·min−1. The non-isothermal kinetic parameters were obtained via the analysi...

The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical field or the food industry. Solid dispersio...

The liquid-liquid phase separation diagrams for dilute aqueous NaCl solutions of dimethyloleylamine oxide have been obtained at temperatures between 5 and 85°C for pH less than 8 at different NaCl concentrations. The liquid-liquid phase separation is induced between pH 3.85 and 4.9 at temperatu...

To elucidate the exact function of CabAS in Centella asiatica, which was previously reported as a putative β-amyrin synthase [Plant Cell Rep, 24:304–311, 2005], this gene was functionally expressed in the lanosterol synthase-deficient yeast mutant (erg7). After inducing the CabAS gene with gal...

Plants produce various types of terpenoids that play an important role in the interaction of the plant with its environments. The last two decades have seen considerable progress in elucidating plant terpenoid biosynthetic pathways at the gene and enzyme levels. However, the biosynthetic evoluti...

Dammarenediol-II is the nucleus of dammarane-type ginsenosides, which are a group of active triterpenoids exhibiting various pharmacological activities. Based on the native triterpene synthetic pathway, a dammarenediol-II synthetic pathway was established in Pichia pastoris by introducing a damm...

BackgroundThe Body Image Concern Inventory (BICI), the Whitely Index (WI), and the Checklist Individual Strength (CIS-20R) are three questionnaires often incorporated in routine outcome monitoring (ROM). Respectively, they assess symptom severity in patients with body dysmorphic disorder, hypoch...

In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin® PMX-F sheets was quantitatively evaluated [1]. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum.Therefore, we investigated whether two types of antimicrobial a...

The aim of this study is to explore facile and large-scale method for the preparation of magnetic adsorbent materials with high-efficient heavy metal removal performance. Here, based on the process intensification of high-gravity technology, the carboxymethyl cellulose-immobilized Fe3O4 nanopart...

Biopolymers can be used to produce nano-objects in solution and they are generally of low cost and biocompatible. However, they commonly have low kinetic stability and form aggregates with a broad particle size distribution, characteristics that hinder their use in drug delivery systems. Herein,...