A novel and efficient reaction has been developed to synthesize a set of substituted 2-aminothiazoles from α-nitroepoxides and ammonium thiocyanate. This reaction could proceed smoothly at mild condition, to afford products for a wide range of substrates with good to excellent yields. A possibl...

Aerobic intramolecular aminothiocyanation of unactivated alkenes has been developed by in situ generated iodine thiocyanate under open-flask conditions. This protocol provides a concise and efficient method for synthesizing SCN-containing pyrrolidine, piperidine and indoline derivatives with iso...

Diphenylacetylenes having a dimethyloctylsilyl group and an alkyl group at para positions [Me2n-C8H17SiC6H4CCC6H4R; R = H (1a), i-Pr (1b), t-Bu (1c), n-Bu (1d)] and having only an alkyl group [PhCCC6H4R; R = i-Pr (1B), t-Bu (1C)] were synthesized and then polymerized with TaCl5/n-Bu4Sn catalyst ...

Poly(diphenylacetylene) [PDPA] derivatives were nitrated using a mixture of nitric acid and sulfuric acid. Nitration of poly[1-(p-trimethylsilyl)phenyl-2-phenylacetylene] (1a) proceeded, and the nitro groups were substituted to trimethylsilyl groups on benzene rings. The degree of nitration (DN)...

A series of diphenylacetylene derivatives [(CH3)3SiC6H4CCC6H4R; R=H (1a), CH3 (1b), n-C4H9 (1c), n-C8H17 (1d), PhC≡CC6H4R; R = CH3 (2b), n-C4H9 (2c), n-C8H17 (2d), t-C4H9 (2e)] were synthesized and then polymerized with TaCl5/n-Bu4Sn to afford the corresponding poly(diphenylacetylene)s (3a–d a...

Two novel phenanthro[9′,10′:4,5]imidazo[2,1-a]isoquinoline derivatives containing phenoxazine moiety were synthesized and characterized by elemental analysis, NMR, MS and FT-IR spectra. Their structures were characterized by single crystal X-ray diffraction. Their photophysical and electrochem...

Related to our research on structural modifications of pentalongin, the active principle of the medicinal plant Pentas longiflora Oliv., a new synthesis of N-protected 1,2-dihydrobenz[g]isoquinoline-5,10-diones and their 4-methyl derivatives, which represent a new class of compounds, is reported...

Interleukin (IL) 22 is a type II cytokine that is produced by immune cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of the recently identified T helper 17 lineage of CD4 + effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in d...

Study DesignProspective questionnaire administration study.

Study DesignLongitudinal cohort.

Study DesignLongitudinal cohort.

BackgroundThe Scoliosis Research Society-22r (SRS-22r) has been shown to be reliable, valid and responsive to change in patients with adult spinal deformity (ASD) undergoing surgery. The minimum clinically important difference (MCID) quantifies a threshold value of improvement that is clinically...

Study DesignCross-sectional Objectives: To present a reliable and valid Danish translation of the Scoliosis Research Society–22R (SRS-22R).

BACKGROUND CONTEXTThe minimal clinically important difference (MCID) is the smallest change in an outcomes instrument deemed relevant to a patient. MCID values proposed in spine research are limited by poor discriminative abilities to accurately classify patients as “improved” or “not improve...

Study DesignLongitudinal cohort.

A combinatorial chemical library of fifty-nine novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a]pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile, designed as hybrid molecules of phenazine, pyran, indole and 1,2,3-triazole pharmacophores, were constructed in this...

Commercially delivered 2-chloro-5-methyl-1,4-phenylenediamine (1 metric ton) was not identical to the commonly used dye intermediate; it was found that the material was a pure but not yet described molecule. 1H, 13C NMR, MS, microanalysis and X-ray diffraction showed that the substance was in fa...

Solid state structures of 2,4-diamino-6-(4-methylphenyl)-1,3,5-triazine, 1, in the form of methanol and dimethylsulfoxide (DMSO) solvates, as well as supramolecular assemblies of 1 with various aliphatic dicarboxylic acids, oxalic (a), malonic (b), succinic (c), glutaric (d) and adipic (e) have ...

Methyl (S)-3-amino-3-(3-pyridyl)propanoate (2) is a key starting material in the synthesis of RWJ-53308 (1), an orally active antagonist of the platelet fibrinogen receptor (GP IIb/IIIa antagonist). Herein, we describe an efficient stereoselective synthesis of 2 by the hydrogenation of enantiome...

Developing multifunctional materials to deal with the complex problem of water pollution has drawn significant concerns in recent time. In this study we report the synthesis of a new bi-functional polymer derived from N,N-dimethylaminobenzaldehyde and glucosamine-based Schiff base grafted poly(a...