The ITER EC system includes both an equatorial port launcher and upper port launchers as RF power injection devices, The waveguide switch in the transmission line (TL) is used to select the operating launcher. Its operation is required even during plasma operation, primarily for the mid-pulse sw...

A Test Facility (TF) has been designed and installed at SPC to allow for the commissioning of the EU gyrotrons developed in view of their integration to the ITER EC system. The first phase of operation of this TF was dedicated to the development of the EU 2 MW coaxial cavity gyrotron [1,2].The E...

Many authors have studied exponentially-convergent tractability in the worst case setting. But almost all articles related to tractability are focused on the classes of some multivariate functions defined over the unit cubes [0,1]m or Rm. Note that simplex is also important in geometry and has m...

BackgroundThe TMPRSS2-ERG gene fusion is the most frequent genetic rearrangement in prostate cancers and results in broad transcriptional reprogramming and major phenotypic changes. Interaction and cooperation of ERG and SP1 may be instrumental in sustaining the tumorigenic and metastatic phenot...

Duloxetine HCl was subjected to forced degradation under conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH guideline Q1A(R2). The drug showed significant degradation under acidic, alkaline and aqueous hydrolytic as well as ...

The present study has examined the anticonvulsant and neuroprotective effect of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC), a selective agonist for group II metabotropic glutamate receptors (mGluRs) when given 10–15 min after the onset of seizures induced in 12-day-old rats by bila...

Sodium azide, applied as microbial inhibitor, has caused unwanted by-products in environmental samples during anaerobic, long-term (2–3 year) experiments. When ignored, this can lead to the misinterpretation of observed phenomena. Sodium azide was indeed found to react with several components o...

A toxicological evaluation of 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid(S9632; CAS 1359963-68-0), a flavour with modifying properties,was completed for the purpose of assessing its safety for use in food and beverage applications. No Phase I bio...

A yellow pigment (C24H26N4PO15Na3) was isolated from Mycobacterium avium. On the acid hydrolysis the pigment (1 mol) gave L-glutamic acid (1 mol), lactic acid (1 mol) and 7,8-didemethyl-8-hydroxy-5-deazariboflavin-5′-phosphoric acid. The structure of N-[O-[[5-(8-hydroxypyrimidol[4,5-b]quinoline...

Laser-flash photolysis was employed to determine absolute rate constants for quenching of 5-deazariboflavin triplet excited state by amines and phenols in methanol solution. The observed reactivity order for triplet quenching by aliphatic amines parallels very well the corresponding trend in oxi...

We evaluated the ability of evolved paraoxonase-1 (PON1) to afford broad spectrum protection against G-type nerve agents when produced in mammalian cells via an adenovirus expression system. The PON1 variants G3C9, VII-D11, I-F11, VII-D2 and II-G1 were screened in vitro for their ability to hydr...

JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancers, and is cryptic on normal cells. JAA-F11 has...

Alzheimer’s disease (AD) is a common neurodegenerative disease which is characterized by aggregation of amyloid beta (Aβ) and hyperphosphorylated tau. We previously reported that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, improved cognitive function and reduced Aβ aggregation in...

Fluoroquinolones are a class of antibiotics widely prescribed in both human and veterinary medicine of high environmental concern and characterized as environmental micropollutants due to their ecotoxicity and persistence and antibacterial resistance potential. Ofloxacin and levofloxacin are chi...

The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and im...

Calcium overload has been reported to trigger neuronal death following stroke. Pseudoginsenoside-F11 (PF11), an ocotillol-type ginsenoside with various neuroprotective activities, has displayed therapeutic efficacy against permanent ischemic stroke. The present study examined the protective pote...

Pseudoginsenoside F11 (PF11) was described considering its complexation capabilities with β- and γ-cyclodextrin. A merged computational/experimental approach was used, and it was found that the PF11 molecule form a stable inclusion complex with the γ-cyclodextrin, with an association constant...

Diclofenac (DCF) is a widely used non-steroidal anti-inflammatory pharmaceutical which is detected in the environment at concentrations which can pose a threat to living organisms. In this study, biodegradation of DCF was assessed using the bacterial strain Labrys portucalensis F11. Biotransform...

The occurrence of pharmaceuticals in the environment is a topic of concern. Carbamazepine (CBZ) is a widespread antiepileptic drug and due to its physical-chemical characteristics minimal removal is achieved in conventional water treatments, and thus has been suggested as a molecular marker of w...

A series of novel amino-carboxylic based pyrazole as protein tyrosine phosphatase 1B (PTP1B) inhibitors were designed on the basis of structure-based pharmacophore model and molecular docking. Compounds containing different hydrophobic tail (1,2-diphenyl ethanone, oxdiadizole and dibenzyl amines...