The aim of this study was to evaluate gold nanoparticles (AuNPs) for their anticancer activity against MCF-7 cancer cells, antioxidant activities and catalysis of the reduction of p-nitrophenol (p-NP). AuNPs were synthesized using kaempferol 3-O-β-D-apiofuranosyl-7-O-α-L-rhamnopyranoside (KG) ...

A broad palette of natural dyes is often mentioned with reference to dyed textiles from ancient China. However, few scientific works address the problem of correctly identifying these dyes, often referring simply to unidentified sources.The aim of this work was the creation of a database of mass...

A high throughput assay was applied to guide the isolation of a new pancreatic α-amylase inhibitor, dracoflavan B, from the dragon’s blood resin from Daemonorops draco. Applying C18 column, we successfully isolated both diastereomers and their structures verified by 1H NMR spectra in compariso...

A new sesquiterpene evoninoate alkaloid, hippocrateine III, was isolated together with the known compound mayteine from the root and stem barks of Hippocratea excelsa. The structures of both compounds were elucidated by interpretation of spectral data. The substitution pattern of the nicotinic a...

A new class of nucleotides, with one of the two non-bridging oxygens at α-phosphorus replaced by a borane (BH3) group, has shown potential applications in DNA sequencing. We have developed a convenient method for the synthesis of the 2′-deoxy-5′-(α-P-borano)triphosphates of adenosine, guanos...

This study evaluates culture filtrate, rich in cellobiose dehydrogenase and laccases, of Termitomyces sp. OE 147, in decolouration and degradation of Reactive blue (RB) 21. About 35% decolouration was achieved at low volumes of the culture supernatant without addition of external redox mediators...

Continuous reactive crystallization of β-lactam antibiotics can ease shortage and contamination concerns for an important class of medicines. With a model of continuous reactive crystallization catalyzed by penicillin G acylase (PGA), a process is developed to ensure purity of the antibiotic pr...

This study researched the use of the easily obtainable and economic agricultural waste of corn silk (CS) for removal of Reactive Blue 19 (RB19) and Reactive Red 218 (RR218) dyes with the adsorption process. Lignin, holocellulose, α-cellulose, thermogravimetric analysis (TGA), fourier transform ...

Due to the severe water pollution from effluent dyes, the need of the hour is to find a suitable dye degradation technology, and appropriate catalyst materials. Semiconducting ZnO was produced by pyrolysis of ZIF-8 template. The materials were well characterized with in situ and ex situ XRD and ...

A specific and sensitive radioimmunoassay was developed for SR 31747A, a new sigma ligand, using a monoclonal antibody. This antibody was produced from spleen lymphocytes of a mouse immunized with SR 31747A coupled to bovine serum albumin via a peptide bond using SR 120684A, a succinamic acid de...

SR 31747 is a sigma ligand which prevents the development of acute graft-versus-host reaction (GvHR) in hybrid B6D2F1 mice injected with C57BL/6 parental spleen cells. In the present study, we showed that this drug dramatically impaired the GvHR-associated increase in the numbers of both B-lymph...

The interactions of a new compound SR 31747 with sigma sites were examined in rat spleen membranes and in human peripheral blood leukocytes (PBL). Nanomolar concentrations of SR 31747 selectively inhibited in a non-competitive manner the binding of the prototypic sigma ligands [3H](+)-pentazocin...

In our preceding paper, we demonstrated that both human and rat lymphocytes possess saturable high-affinity binding sites for the new sigma ligand SR 31747. Here we investigate the potential activity of this ligand on immune responses. In vitro, our study shows that SR 31747 exerts a concentrati...

Publisher SummaryThis chapter discusses the reaction of 2, 4-Dialkoxypyrimidines with Halogenoses. The reaction of a 2, 4-dialkoxypyrimidine with a halogenose or an alkyl halide has been assumed to proceed via a quaternary salt as intermediate. Thus, the stable l-methyl-2-methoxy-4-aminopyrimidi...

In frog skin, tachykinins stimulate ion transport by interaction with NK1-like receptors. The structural requirements of the peptide are the presence of the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and at least one Pro residue in the N-terminal sequence. In this paper, we demonstrate that the C...

The title acid, a component of microsclerodermins of marine sponge origin having five consecutive stereogenic centers, was efficiently synthesized as its proctected form 1 from the alcohol 5 utilizing the stereoselective addition of anisole to the acetylenic triple bond and the anti-aldol reacti...

Bio-based sorbitol azelaic acid ester (SAAE) is an alternative to the fossil fuel derived polyester polyol for polyurethane production. The quality of SAAE is affected by the composition of sorbitol (SL) and its anhydrides azelate. Unavailability of the standard of these esters renders the compo...

Valerenic acid (VA) is a β2/3 subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis. Here we analyze if VA-esters can serve as prodrugs and if different ester structures have different in vitro/in vivo effects. Modulation of GABAA receptors expre...

A spectrophotometric analysis of the UV-spectrum of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (I) in 0.01 M HCl was performed by determining the values of specific absorption coefficients at the following analytical wavelengt...

Five novel methyl (±)-2-(2-acetoxyethyl)-4-arylmethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylates have been synthesized and their lipase-catalyzed resolution via stereoselective deacetylation of acetoxyethyl moiety present in the molecule studied. It has been observed that Novozyme®-435...