SummarySome 2-(2-thiazolylazo)-5-(sulfomethylamino)benzoic acid derivatives are synthesized. Among them, 2-(2-thiazolylazo)-4-methyl-5-(sulfomethylamino)benzoic acid (TAMSMB) is very sensitive (ε = 1.13 × 105 l mol-1 cm-1 at λmax 655 nm) and selective for the spectrophotometric determination ...

2-(4′-methyl-2′-thiazolylazo)-4,6-dimethylphenol has been synthesized and its acid—base behaviour (pKa1=0.03 ± 0.01, pKa2=9.70±0.09) and complexation equilibria with zinc (logβ101=6.70±0.04, logβ102 = 13.70±0.02) studied in a 40% (v / v) ethanol—water medium at I=0.25 M NaClO4. A spect...

4-(4′-Methyl-2′-thiazolylazo)-2-methyl-resorcinol reacts with vanadium (V) to produce a bluish-violet 1:1 complex (λmax = 560 nm, ϵ = 2.50 × 104 M−1 · cm−1, 50% methanol-water medium), which allows the spectrophotometric determination of 0.1 to 1.4 ppm of vanadium. The method has been appli...

The complexation equilibria between CdII and 4-(4′-methyl-2′-thiazolylazo)-2-methyl-resorcinol have been spectrophotometrically studied in an ethanol-water medium (50 : 50, v/v) at I = 0.25 M (NaClO4) and species CdHR2 (logβ112 = 20.38 ± 0.09) and CdH2R2 (logβ122 = 27.00 ± 0.09) are establ...

The pollution of phthalate esters (PAEs) remains an important issue in the world. Current studies mainly focused on atmospheric PAEs in urban area with strong anthropogenic activities, but there were no studies on PAEs in the ambient air around large natural lake. This paper focused on two sites...

This study describes the development of a novel and sensitive UPLC-MS/MS method for simultaneous determination of diethyl phthalate (DEP) and its major metabolite, monoethyl phthalate (MEP), in rat plasma, urine, and 11 different tissues collected from a toxicokinetic study. Analytes were separa...

The ubiquity and potential toxicity of phthalates make their exposure on humans a matter of great concern. Measuring the targeted phthalate metabolites using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a commonly used approach for human biomonitoring of phthalates. However, the ...

Endocrine disrupting chemicals (EDCs) such as phthalates and bisphenol A (BPA) are substances that may interfere with the actions of endogenous hormones and may be associated with estrogen-related diseases such as endometriosis. This paper describes a case-control study to evaluate the relations...

Dimeric complexes, bis[dihalo(2-dimethylaminomethyl-3-hydroxypyridine)-copper(II)], [Cu(dmamhp)X2]2, were prepared from the reaction of copper(II) halide (Cl, Br) with 2-dimethylaminomethyl-3-hydroxypyridine (dmamhp) in methanol, and their single crystal structures were determined. The chloro co...

In this work, the spectroscopic characterization of 2,4,6-tris(dimethylaminomethyl) phenol; a novel promoter factor for DNA has been studied primarily. The FT-IR (4000–400 cm−1) and FT-Raman (3500–100 cm−1) spectra have been recorded on the solid phase of the title molecule. The spectroscopic ...

Two 3-diethylaminomethyl-5-R-salicylic aldehydes were obtained and studied in chloroform solutions by FTIR and NMR spectroscopy. The existence of an equilibrium between the structures with OH⋯OC and N⋯HO intramolecular hydrogen bonds was suggested. In the case of compound 1 (R=OCH3) the OH⋯O...

Deprotonation of 4-nitrophenyl-phenylcyanomethane and 4-bromophenyl-4-nitrophenylcyanomethane by cis 1,2-bis(diethylaminomethyl)cyclohexane (DEAMCH) base with proton sponge-like character in acetonitrile is studied by kinetic as well as FT-IR spectroscopic methods. The mechanism of the proton tr...

The inhibition of the human serum cholinesterase phenotypes, usual (U), atypical (A) and heterozygous (UA), by the dimethylcarbamate of (2-hydroxy-5-phenylbenzyl)-trimethylammonium bromide (Ro 02-0683), was followed with benzoylcholine, acetyl-, butyryl- and propionyl-thiocholine as substrates. ...

Human Islet Amyloid Polypeptide or amylin is a neuroendocrine peptide with important endocrine and paracrine functions. Excessive production and accumulation of human amylin in the pancreas can lead to its aggregation and apoptosis of islet β-cells. Amylin has been shown to function within the ...

Apart from its relevance to pathology, protein misfolding disease like Type-II Diabetes Mellitus, caused by amyloids of amylin protein has attracted more attention due to structural changes occurring during the aggregation process. We report extensive spectroscopy data of amylin during fibril fo...

The selectivities of the diadenosine polyphosphates (ApnAs, n=2–6) at the human P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11 receptors stably expressed in 1321N1 human astrocytoma cells was determined using a Fluorescence Imaging Plate Reader (FLIPR) to measure intracellular Ca2+ mobilisation. The rank ord...

Two novel series of 4-thiazolidinone derivatives, namely 2′,4′-difluoro-4-hydroxybiphenyl-3-carboxylic acid [2-(5-nitro-2-furyl/substituted phenyl)-4-thiazolidinone-3-yl]amides (5a–g) and 2-(2′,4′-difluoro-4-hydroxybiphenyl-3-carbonylhydrazono)-3-alkyl/aryl-4-thiazolidinones (6a–e) togethe...

Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (1R,2R)- and (1S,2R)-2,3-O-cyclohexylidene-1,2,3-trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightl...

Three series of 5-thio-1,3,4-thiadiazole carbamates containing alkynyl, aminoalkynyl, alkenyl or alkyl thio substituents have been synthesized as potential antimicrobial agents. The influence of both the alkynyl linkage and the various terminal nitrogen heterocyclic moieties on antimicrobial act...

A one-pot two-step synthetic strategy for the preparation of aryl carboxamido sulfonic acid derivatives was developed. The synthesis started from m-(chlorosulfonyl)benzoyl chloride, which was reacted with amines, alcohols, thiols, or sodium azide and catalytic activator at rt to give the corresp...