Testosterone cypionate and Stanozolol are Anabolic-Androgenic Steroids (AAS) which are synthetic substances that possess functions similar to testosterone. The use of these substances has increased considerably among youngsters and sports practitioners aiming better performance of with aesthetic...

Stanozolol is a widely used 17α-alkylated anabolic androgenic steroid (AAS) derivative. Despite stanozolol’s adverse effects, its effect on oxidative stress parameters and mitochondrial apoptosis pathway is not clearly defined. In our study, thirty four male Sprague-Dawley rats were divided in...

SummaryBackground & aimsNeoadjuvant chemoradiotherapy (NACRT) for pancreatic cancer (PC) is potentially associated with various toxicities, which can lead to impaired nutritional status. Eicosapentaenoic acid (EPA) can reduce proinflammatory cytokines and positively influence cancer cachexia syn...

To extend the application of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in liquid food, and to improve the physicochemical stability, we prepared stable DHA and EPA nanoemulsions, which can be used for large scale production. The Emulsion Phase Inversion (EPI) method was used to ...

Eicosapentaenoic acid (EPA) enriched phospholipids (EPA-PL) are widely distributed in marine products. It has been reported that the protective effects of the mixture of EPA and docosahexaenoic acid (DHA) on Parkinson’s disease (PD), however, it is hard to confirm the improvement of EPA alone o...

A study has been made of the stoichiometry of the reaction between an acid solution of mercurous nitrate and ferric iron in the presence of excess of thiocyanate ions. Amounts of iron between 3.0–300 mg were determined using solutions of mercurous nitrate of different concentrations. Under the ...

A rapid, precise and low cost method for saccharin determination in dietary products is proposed. Saccharin in several samples is potentiometrically titrated with mercurous nitrate solution using a silver wire coated with a metallic mercury film as the working electrode, and the end point was fo...

The following twelve mercurous and mercuric organophosphomates, bis/diphosphonates and phenylarsonates have been isolated and structurally characterized by single crystal X-ray diffraction, 13C-and 31P NMR, infrared and Raman spectroscopic methods: Hg2(HO3PC6H5)2(1), Hg2(HO3P(C6H4)PO3H)(2), Hg2(...

A simple method for immobilization of malonaldehyde-acetaldehyde conjugate adduct with DNA base onto an amino-terminated surface of silicon from water solution is proposed. The Si(001) surface which contains OH groups was modified with 3-aminopropyltrimethoxysilane (APTMS) to serve as a linker b...

A novel, general, and efficient one-pot sequential reaction toward a variety of 4-aminated-6-arylpyrrolo[2,3-d]pyrimidines from 5-alkynylpyrimidines has been developed. Microwave-assisted metal-free intramolecular cyclization and amination provided moderate to excellent yields of 4-aminated pyrr...

Series of ring-halogenated histidines and histamines have been synthesized from the suitably protected parent bioimidazoles. The 5-X and 2,5-X2-derivatives are obtained by direct electrophilic halogenation while 2-X derivatives (X= Br and I) are prepared by regiospecific electrophilic dehalogena...

Present work explored the potential of the use of hydrophobic ionic liquids (ILs) for the extraction of high-value products nicotinic acid (NA) and niacinamide from aqueous phase. The extraction efficiency highly depended on the chemical structures of ILs. The increase in the side chain length o...

Mechanistic studies with N-benzyl-1-aminobenzotriazole (BBT)-inactivated cytochrome P450 2B1 were conducted to determine which step(s) in the reaction cycle had been compromised. Stopped-flow studies, formation of the oxy–ferro intermediate, and analysis of products suggested that the reductive...

2-Phenyl-1H-benzimidazoles 7a–e were synthesized and tested for gene activation on ERα-positive MCF-7 breast cancer cells, stably transfected with the reporter plasmid EREwtcluc (MCF-7-2a cells). None of the compounds showed agonistic properties, but they antagonized dependent on hydroxyl grou...

The oxo-centered, trinuclear, mixed valence [Ru3(II,III,III)O(CH3CO2)6(H2O)3]·2H2O (2) acetate complex has been prepared with high yield through reduction of [Ru3(III,III,III)O(CH3CO2)6(CH3OH)3]·CH3CO2 precursor compound in presence of muccic acid under hydrothermal conditions. The crystalline...

A new method based on near-infrared (near-IR) fluorescence recovery was presented for the determination of nucleic acids. This method employed a two-regent system composed of anionic tetracarboxy aluminum phthalocyanine (AlC4Pc) and polycationic poly-lysine. The fluorescence of AlC4Pc, with the ...

Two monoglucuronides (CA1G1 and CA1G2) of the catecholic cis-stilbene Combretastatin A1 (CA1, OXi4500), have been identified in a clinical trial of the bisphosphate prodrug of OXi4500, OXi4503. A validated assay for the two glucuronides in human plasma using HPLC with fluorescence detection afte...

SummaryThe synthesis and the evaluation of the monoamine oxidase A and B inhibitory activities of 21 new substituted acylhydrazones of various aromatic aldehydes and 4-(benzyloxy)acetophenone, and four substituted semicarbazones of benzaldehyde and 4-(benzyloxy)benzaldehyde, are described. The 4...

A targeted series of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives were synthesized and evaluated in vitro against the malarial cysteine protease falcipain-2 and a chloroquine resistant strain (W2) of Plasmodium falciparum. A novel series of 4-aminoquinoline semicarb...

Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2–3 steps from readily available starting materials. Some...