BackgroundMushrooms have been used in Asia as traditional foods and medicines for a long time. Ergosta-4,6,8(14),22-tetraen-3-one (ergone) is one of the well-known bioactive steroids, which exists widely in various medicinal fungi such as Polyporus umbellatus, Russula cyanoxantha, and Cordyceps ...

To improve the therapeutic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone), a folate–decorated ergone–bovine serum albumin nanoparticles (abbreviated FA–ergone–BSANPs) was prepared. The properties were extensively studied by Zetasizer Nano Particle Size Analyzer and TEM, which indicate...

λ-Carrageenan extracted from Gigartina skottsbergii tetrasporophyte was completely digested by a purified Pseudoalteromonas carrageenovora λ-carrageenase. The main digestion products were fractionated and analysed by 1H and 13C NMR spectroscopy. All the oligosaccharides observed belong to the ...

The biotransformation of naringin and naringenin was investigated using cultured cells of Eucalyptus perriniana. Naringin (1) was converted into naringenin 7-O-β-d-glucopyranoside (2, 15%), naringenin (3, 1%), naringenin 5,7-O-β-d-diglucopyranoside (4, 15%), naringenin 4′,7-O-β-d-diglucopyra...

This paper reports phase equilibrium (temperature–composition) relations of semiclathrate hydrates formed from tetra-n-butylphosphonium propionate (TBP-Pro) and butyrate (TBP-But) + water systems. Their maximum solid–liquid phase equilibrium temperatures at atmospheric pressure were located at...

Dietary supplementation of vitamin E (VitE) in a synthetic or natural form was examined. Forty-eight lambs were assigned (n = 16) to either a grain-based diet at moderate (MOD, 42 mg∙kg−1 VitE as all-rac α-tocopheryl acetate) or supranutritional (SUP, 285 mg∙kg−1 of vitE) levels of synthetic Vi...

We previously demonstrated the ethanol extract of the roots of Brassica rapa protects against cisplatin-induced nephrotoxicity by attenuating oxidative stress. Here, we investigated the nephroprotective effects of 6-hydroxy-1-methylindole-3-acetonitrile (6-HMA), which was isolated from the roots...

Michael addition of dibenzylamine to (−)- and (+)-tert-butyl myrtenate, (−)-2 and (+)-2, derived from (−)- and (+)-myrtenal, furnished monoterpene-based β-amino acid derivatives in highly stereospecific reactions. The resultant amino esters (−)-3 and (+)-3 were transformed to unsubstituted, mon...

Diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] is a herbicide that induced urothelial tumors in the urinary bladder of Wistar rats fed 2500 ppm during a long-term study. The currently suggested non-genotoxic mode of action (MOA) of diuron encompasses in succession urothelial necrosis induced b...

In the search for potent and selective human β3-adrenergic receptor (AR) agonists as potential drugs for the treatment of obesity and noninsulin-dependent (type II) diabetes, we prepared a novel series of phenoxypropanolamine derivatives containing the thiourea moiety and evaluated their biolog...

A series of new thiourea derivatives of 1,2,4-triazole have been synthesized. The difference in structures of obtained compounds are directly connected with the kind of isothiocyanate (aryl/alkyl). The 1H NMR, 13C NMR, MS methods were used to confirm structures of obtained thiourea derivatives. ...

As a novel fusogenic liposome, we designed liposomes modified with poly(glycidol) having β-alanine residues, which is a poly(ethylene glycol) derivative with positively charged groups. The polymer-modified liposomes of egg yolk phosphatidylcholine (EYPC) and dioleoylphosphatidylethanolamine (DO...

Imidazolium based dicationic room temperature ionic liquids (RTILs) were synthesized, characterized, and investigated their physicochemical properties along with catalytic activity in azidation reaction. In this method two N-methylimidazolium cations were bridged with different short oligo (ethy...

Thermophysical properties viz. density ρ, speed of sound u, refractive index nD, and specific conductivity κ for aqueous solution of ionic liquid; 2-hydroxyethyl-trimethylammonium Acetate; [(C2H4OH)-(CH3)3N] [Acetate] (Choline Acetate) have been studied over the whole concentration range at di...

Electrospinning technique has been explored to produce nanofibers incorporated with drugs as alternative drug delivery systems for therapeutic purposes in various organs and tissues. Before such systems could potentially be used, their biocompatibility must be evaluated. In this study, dexametha...

Surface tailoring is an attractive approach to enhancing selective endothelialization, which is a prerequisite for current vascular prosthesis applications. Here, we modified polycarbonate urethane (PCU) surface with both poly(ethylene glycol) and Cys–Ala–Gly-peptide (CAG) for the purpose of c...

SummaryThe peptidases in rat basophilic leukemia cells, guinea pig lung, peritoneal eosinophils and limpet arylsulfatase preparation were shown to inactivate SRS-Cys-Gly but not SRS-GSH and SRS-Cys. The SRS-Cys-Gly inactivating peptidases were resolved from arylsulfatases in these cell systems. ...

The metal ion binding properties of a phytochelatin (PC) analogue, (Glu–Cys)4–Gly (named as EC4), have been studied by a divalent metal ion binding assay monitored by UV–visible spectroscopy, circular dichroism and NMR spectroscopy. Spectro- photometric titration with different divalent metal...

Hydrogenase is the key point of H2-based biotechnology. However, the O2-sensitivity largely hinders its applications in biofuel cells and biological H2 production. Therefore, substantial breakthrough on understanding the molecular basis of O2-sensitivity and developing more O2-tolerant hydrogena...

The dipeptide, Arg–Cys, and the related molecule, Arg–cysteamine, are adsorbed to gold surfaces and the monolayers are characterized. Chemical binding and electronic structure of the monolayers are obtained by X-ray photoelectron spectroscopy (XPS). Strong molecular binding of the adsorbates t...