NSC-281612 (4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde, 1), is a chemically unstable, poorly water soluble, experimental antineoplastic agent. The saturated solubility in water at 25°C was determined as ∼30 μg/mL. In the pH range 2–11, 1 displayed pH-independent stabili...

2-[(Trimethylsilyl)methyl]-3-chloro-3,3-difluoropropene, readily prepared in two steps from methyl chlorodifluoroacetate and (trimethylsilyl)methylmagnesium chloride, is reduced to couple regioselectivity with a variety of carbonyl compounds in the presence of zinc-copper(I) chloride or -silver ...

Microbial reduction with baker's yeast or Aspergillus niger of methyl 4-chloro-4,4-difluoro-3-oxobutanoate 1 afforded the optically active methyl (−)-4-chloro-4,4-difluoro-3-hydroxybutanoate 2. When yeast reduction was carried out in the presence of allyl bromide the optically active methyl...

Dimer model compounds of polyvinylanthracenes (1,n-di(9-anthryl)alkanes, when n = 1–5) were synthesized to model the effects of distance and orientation between anthracene groups in polymeric systems. Charge transfer (CT) complexes of anthracene, 9-methylanthracene and 1,n-di(9-anthryl)alkanes ...

The fluorescence properties and photoisomerization behavior for trans and cis isomers of 1-(9-anthryl)-2-(2-pyrazinyl)ethene (APzE). a diaza analogue of 1-(9-anthryl)-2-phenylethene (9-APE), were studied. The fluorescence maximum (λ1). quantum yield (Φt) and lifetime (τt) of t-APZE were solve...

Eight 2-(9-phenanthrenyl)-, 2-(9-anthryl)- and 2-(1-pyrenyl)-1-alkyl-benzimidazole compounds, three 2-(9-anthryl)-1-alkylphenanthroimidazole compounds and five 4,5-diphenyl-1-alkyl-2-(9-anthryl)imidazole compounds were synthesized by alkylation reactions of the corresponding benzimidazole, phena...

Tridentate terpyridine is a functional building unit, and 9-anthylterpyridine has been used as ratiometric fluorescent sensor for Cd(II) and secondary sensor for pyrophosphate detection. Here we have inserted a phenyl unit between 9-anthryl and terpyridine to synthesize a new terpyridine derivat...

The spectroscopic and photophysical properties of 1,3-di(9-anthryl)benzene (DAB), 1,3,5-tri(9-anthryl)benzene (TAB), and tri(9-anthryl)borane (TABO) in tetrahydrofuran were reported, together with those of 9-phenylanthracene (MAB). Although MAB, DAB, and TAB showed structured absorption spectra ...

Poly[N-9′-heptadecanyl-2,7-carbazole-alt-5,5-(4′,7′-di-2-thienyl-2′,1′,3′-benzothiadiazole)] (PCDTBT) is a low bandgap carbazole-based copolymer, successfully employed in bulk heterojunction solar cells and field-effect transistors. In this work, we report on the possibility to dramaticall...

The inclusion complexes of a series of m- and p-nitrophenyl alkanoates have been studied using molecular mechanics and molecular dynamics computations. Inclusion complexes are likely to exist for the m-series while external complexation seems to be important in the p-series. Solvation effects de...

The nipecotic acid ester, (±)-m-nitrophenyl-3-piperidinecarboxylate hydrochloride (MNPC) is a potent inhibitor of uptake of GABA in vitro and should be able to penetrate into the brain much more readily than the parent compound nipecotic acid. A study of the effects of MNPC on convulsions induc...

− (±)-5-Me-8-OH-DPAT 4 was synthesized by a new synthetic pathway recently described by us. The (+)- and (−)-enantiomers 4 were prepared from the primary amine 8 by crystallisation of the (+)- and (−)-mandelic acid salts. The enantiomers reacted with propyl iodide and were demethylated by 48% H...

31P-NMR measurements of saturation transfer have been used to measure exchange between the γ-phosphate of ATP and phosphocreatine and between the β-phosphate of ATP and the β-phosphate of ADP in the reaction catalysed by creatine kinase in vitro. The calculated exchange fluxes have been compa...

Dogs were given a tracer dose of 14C-creatine. A substantial fraction of the administered radioactivity is excreted in urine (27.5% in 5 days, 67% in 17 days); residual activity is concentrated in skeletal and smooth muscle (3–6% in other major viscera). However, tissue radioactivity of muscle ...

Because of the localization of creatine in muscle, the feasibility of using isotopic dilution of 14C-creatine to estimate muscle mass in vivo was investigated. Rats were sacrificed at daily intervals following the administration of 1–2 μc. of 1-14C-creatine I.V. Urine and stool were the major ...

4-(1H-imidazol-1-yl) aniline (AN) was immobilized on Sepharose CL-6B (AN-Sepharose) for use as a new ligand of mixed-mode chromatography. Adsorption equilibria of immunoglobulin G (IgG) and bovine serum albumin (BSA) to AN-Sepharose were studied at extensive pH values (4.0–8.8) and salt concent...

We have synthesized a series of novel 4-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)pyridine derivatives. The structures of these compounds were confirmed by IR, HR-MS, 1H and 13C NMR spectra. The compound 5g was also confirmed by single crystal XRD. The geometry of the synthesized compounds 5a–5...

This article presents optical, electrochemical, and thermal properties of novel class of green fluorescent 1-(4,5-diphenyl-1-p-tolyl-1H-imidazol-2-yl)naphthalen-2-ol. Detailed photo physical and quantum chemical studies have been performed to elucidate the excited state intramolecular proton tra...

Fungal infections are a growing health threat to mankind. The development of novel potent antifungal agents is a challenge to overcome the resistance to the available antifungal medications. The current report focuses on the synthesis and spectroscopic characterization of a new imidazole-bearing...

To expand our knowledge on the evolution of prepro-thyrotropin-releasing hormone (ppTRH) from fish to tetrapods, sequences of ppTRH cDNAs from two cyprinid teleosts, the common carp Cyprinus carpio and goldfish Carassius auratus, were determined. Degenerate primers were designed based on the con...