BackgroundMultidrug resistance (MDR) in cancer is one of the main obstacles in treatment with chemotherapy. Drug efflux through P-glycoprotein is the major mechanism involved in MDR. A potential strategy to provide the best possible clinical outcomes is to develop P-glycoprotein (P-gp) inhibitor...

The 13C NMR spectra of a range of amentoflavone and hinokiflavone biflavonoids are reported, most for the first time. Substituent shifts relating to the interflavonoid linkages and to specific methylation patterns are defined and appear to be of diagnostic value.

Liver diseases are one of the fatal syndromes due to the vital role of the liver. Most of the effective treatment of liver conditions are of natural origin. Silymarin (SI) is the standard drug used for treatment of impaired liver functions. Two natural compounds possessing promising liver protec...

Melanoma, the highest degree of malignancy, is one of the most common skin tumors. However, there is no effective strategy to treat melanoma in current clinical practice. Therefore, it is urgent to find an efficient drug to overcome melanoma. Here, the in vitro anticancer effects of a natural pr...

Hinokiflavone (HF), belonging to biflavonoids, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Nevertheless, its metabolism in vivo (rats) and in vitro (rat liver microsomes and intestinal flora) is presently not characterized. In ...

The vibrational frequencies and infrared intensities of 5-chloro-6-(4-chlorobenzoyl)-2-benzothiazolinone (abbreviated as CCB) molecule in the ground state were calculated by HF and DFT (B3LYP and BLYP) methods using different basis sets to elucidate the molecular structure. The solid-state FT-IR...

HIV-1 integrase (IN) has emerged as an important therapeutic target for anti-HIV drug development. Its uniqueness to the virus and its critical role in the viral life cycle makes IN suitable for selective inhibition. The recent approval of Raltegravir (MK-0518) has created a surge in interest an...

An efficient and green approach for the preparation of novel isatin-based conjugates with 2-amino thiazol-4-ones is described by the one-pot reaction of isatin derivatives, rhodanine, and secondary amines in the presence of magnesium oxide nanoparticles as a heterogeneous catalyst in water as a ...

The action on graphite of the nitronium salts NO2BF4, NO2PF6, and NO2SbF6 dissolved in dry nitromethane has led to the formation of novel intercalation compounds. These compounds have been synthesized in a wide variety of states and characterized with respect to X-ray identity period along the c...

The pyrolysis of the hex-5-en-1-yl radical was studied with the use of 6-bromo-1-hexene as the precursor. Shock tube experiments were completed at high pressures (40, 100, and 200 bar) and temperatures (900 to 1450 K) with dilute mixtures of 6-bromo-1-hexene (approximately 160 ppm) to determine ...

An electrochemical sensor based on molecularly imprinted polymer (MIP) film for dodecyl gallate detection at the surface of a glassy carbon electrode (GCE) was proposed in this paper. The GCE was modified with f-MWCNT and the MIP synthesis was performed in situ by means of electropolymerization ...

Nanocomposites based on poly(methyl methacrylate) (PMMA) and TiO2 nanoparticles were synthesized by in situ radical polymerization of MMA in solution. The surface of TiO2 nanoparticles was modified with four gallic acid esters (octyl, decyl, lauryl and cetyl gallate). The content of gallates pre...

An efficient method for the synthesis of novel antioxidants in the form of ionic liquids (ILs) was described in the framework of this study. The ILs were obtained by the reaction of quaternary ammonium hydroxides with gallic acid as well as the protonation of amphoteric betaine. The following ph...

Rough lemon rootstock seedlings were held in 14-l. plastic tanks containing solutions of the pigments dihydrofusarubin (DHF), isomarticin and a mixture (T-79; 80% DHF and 20% isomarticin) of the two extracted from cultures of Fusarium solani. Both pigments, together or alone, caused initial leaf...

A variety of fused 3-amino-1,2,4-triazole derivatives were synthesized via addition of aryl hydrazines to isothiocyanates followed by I2-mediated oxidative cyclodesulfurization. This transition-metal-free synthetic process provides facile access to 1,2,4-triazolo[4,3-a]pyridines and related hete...

Cobalt ferrite nanoparticles are of interest because of their room temperature coercivity and high magnetic anisotropy constant, which make them attractive in applications such as sensors based on the Brownian relaxation mechanism and probes to determine the mechanical properties of complex flui...

Aniline-denaturated rape-seed food oils that contained anilides of linoleic and oleic acids caused a poisoning epidemic, known as Toxic Oil Syndrome, in Spain in 1981. Toxic Oil Syndrome affected mainly the lungs and the immune system of exposed individuals. Linoleic and oleic acids, and linolei...

The non-ionic detergent octyl glucoside solubilizes a substantial amount of Streptococcus faecalis membrane protein without loss of the monitored enzyme activities. A secondary detergent, dioctanoyl phosphatidylcholine, appears to increase the yield of solubilized material. In addition, the effe...

Diels-Alder reactions of the annelated pentalene 2 lead to [4.3.3]propellanes. Various substituted anthracenes 3 and cyclopentadienes 5 are tested as diene components. 2 may be classified as a rather electron-rich dienophile.

The regioselectivities were determined for alkylations of 4-methyl-, 2,4-dimethyl-, 2-amino-4-methyl-, 2-chloro-4-methyl-, 2-ethoxy-4-methyl-benzimidazole, and 4-methylbenzimidazolone (as anions in dimethylformamide) with a variety of primary alkylating agents. These N1/N3 regioselectivities are...