This study proposes a method for identifying 1,3-dichloro-2-propanol and 3-chloro-1,2-propandiol in aqueous matrices by using headspace on-fiber derivatization following solid-phase microextraction combined with gas chromatography–mass spectrometry. The optimized SPME experimental procedures fo...

A novel base treatment followed by liquid-liquid extraction was developed to remove the interference of excess derivatization reagent BSTFA [N,O-Bis(trimethylsilyl)trifluoroacetamide] and its byproducts for trace determination of 1-chloro-2-propanol and 2-chloro-1-propanol in a food additive. Th...

SummaryBackgroundMetopimazine is an antiemetic drug already used by oral and rectal administration. It would be interesting to develop a new formulation for a transdermal administration.

PurposeThe objective of the current study was to determine the ability of some antiemetic compounds to cross the blood–brain barrier (BBB) and thereby to determine possible side effects of compounds for the central nervous system (CNS).

Accurate, selective and sensitive stability indicating high performance thin layer chromatographic (HPTLC) method was developed and validated for determination of Metopimazine (MPZ) in presence of its degradation products; including the oxidative degradation product (Deg I) and the alkaline hydr...

The present study was designed to investigate the effect of bromopropylate on its own transport rate, glycolysis and tricarboxylic acid cycle metabolite levels, adenine nucleotides, and membrane lipid peroxidation (LPO) as well as the activities of mitochondrial electron transport chain (ETC) en...

Racemic expectorant guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol 2 undergoes spontaneous resolution upon crystallization. This fact is confirmed by thermal analysis (single eutectic V-shape binary melting phase diagram, adequate entropy and free energy characteristics). Racemic 2 could be e...

New bi- and trivalent transition metal complexes of ligand 3-(2-methoxyphenoxy)propane-1,2-diol (GFS) were synthesized. The ligand and complexes were characterized via: melting point, UV/Visible, IR, 1H NMR, mass and diffused reflectance spectroscopy. The molecular structure of the investigated ...

A versatile and simple strategy is presented to synthesize reactive polylactide derivatives and their block copolymers with polyethylene glycol. Commercially available glycidyl ethers with an allyl, benzyl or propargyl functional group were copolymerised with d,l-lactide. Tin(II)-2-ethylhexanoat...

The natural 7-amino-5,8-quinolinodione antibiotics were the substrate for the NQO1 protein. The structure-activity relationship showed that the 5,8-quinolinedione moiety was responsible for the interaction with the enzyme. In our research, we presented the synthesis, cytotoxic activity and theor...

This research aimed to monitor the concentrations of sulfamethoxydiazine (SMD), sulfamethazine (SMT), sulfamethoxazole (SMX) and sulfadiazine (SDZ) in imported Pangasius catfish products in Thailand. The residues of the four sulfonamides (SAs) were analyzed by extraction process and liquid chrom...

Sulfamethoxydiazine (SMD), which is often used for animal disease treatment, is harmful to human health. No SMD residue should be detected in food in some countries, such as USA and Japan. Therefore, it is significant to develop a high-throughput, high-sensitivity and accurate method for the det...

Three different S, N and Se-modified methyl salicylate derivatives, methyl 2-hydroxy-4-(pyridin-2-yl)benzoate (MHPB), methyl 2-hydroxy-4-(thiophen-2-yl)benzoate (MHTB) and methyl 2-hydroxy-4-(selenophen-2-yl)benzoate (MHSB) have been synthesized and their photophysical properties are examined in...

The preparation of 5′-O-dimethoxytrityl (DMT) and p-nitrophenylethyl (NPEOC, NPE) protected nucleosides linked to 4-(2-hydroxyethyl)-3-nitrobenzoic acid derivatives is described. These products attached to controlled-pore glass supports and together with DMT and NPE-protected nucleoside cyanoet...

A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe–Ziegler cyclization of the dinitrile to form an intermediate β-...

Net retention volumes per gram of N-2-cyanoethyl-N-methylaminosilica have been measured for a large number of mono- and disubstituted benzenes, some mono-substituted (cyclo)hexanes and a number of unsubstituted polycyclic aromatic hydrocarbons, using n-hexane, methylene chloride and a mixture of...

The miscibility behaviour of poly(cyanomethyl methacrylate) (PCYMMA) and poly(2-cyanoethyl methacrylate) (PCYEMA) with poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(2-hydroxypropyl methacrylate) (PHPMA) has been studied by differential scanning calorimetry and Fourier-transform infrared (FT...

Vibrational spectral analysis and quantum chemical computations based on density functional theory have been performed on the N-(2-cyanoethyl)-N-butylaniline. The geometry, structural properties, intermolecular hydrogen bond, and harmonic vibrational frequencies of the title molecule have been i...

In situ SERS measurements were performed during the potentiostatic electrodeposition of Cu from an acidic cupric sulphate solution containing 4-{2-[1-(2-cyanoethyl)-1,2,3,4-tetrahydroquinolin-6-yl]diazenyl} benzonitrile (CTDB). CTDB is a model leveller for Cu electroplating in ULSI semiconductor...

Two synthetic approaches have been explored to prepare 6-deoxyanthracyclinones in general and α-citromycinone in particular. The first approach employed as starting materials 1,4,5-trimethoxynaphthalene and the Diels-Alder product from butadie regioselective carbon acylation of 4-hydroxy-l,5-di...