Hypothermia is a powerful neuroprotective method when induced following cardiac arrest, stroke, and traumatic brain injury. The physiological effects of hypothermia are multifaceted and therefore a better knowledge of its therapeutic targets will be central to developing innovative combination t...

In this review we discuss the structure and functions of the aspartate/glutamate carriers (AGC1-aralar and AGC2-citrin). Those proteins supply the aspartate synthesized within mitochondrial matrix to the cytosol in exchange for glutamate and a proton. A structure of an AGC carrier is not availab...

SummaryMitochondrial function is important for aspartate biosynthesis in proliferating cells. Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis. Insufficient cytosolic aspartate delivery leads...

SummaryCalcium-dependent inactivation (CDI) is a fundamental autoregulatory mechanism in CaV1 and CaV2 voltage-gated calcium channels. Although CDI initiates with the cytoplasmic calcium sensor, how this event causes CDI has been elusive. Here, we show that a conserved selectivity filter (SF) do...

IntroductionAlzheimer's disease (AD) symptoms reflect synaptic dysfunction and neuron death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl-D-aspartate receptors (NMDARs), contributing to synaptic dysfunction. The study described here tested the hypothesi...

N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity...

Our earlier work established a convenient assay procedure for acetoxycoumarin (AC): protein transacetylase (TA) by indirectly quantifying the activity of glutathione (GSH)-S-transferase (GST), the extent of inhibition of GST under the conditions of the assay represented TA activity. In this comm...

A major limitation of high-performance liquid chromatographic techniques for measuring biologically active eicosanoids has been the inadequate sensitivity of most on-line detection systems. In addition, the availability of a technique suitable for measuring small quantities of non-esterified fat...

A sytem for the high-performance liquid chromatography of carboxylic acids using 4-bromomethyl-7-acetoxycoumarin (Br-Mac) as the fluorescence reagents is described. Br-Mac reacts with carboxylic acids to give the ester derivatives, which are separated using reversed-phase liquid chromatography. ...

High-performance liquid chromatography of prostaglandins is developed in which a fluorescence reagent, 4-bromomethyl-7-acetoxycoumarin is used to perform the high-sensitivity detection. The reagent reacts with prostaglandins and related compounds to form the ester derivatives, which are separate...

Three 9,10-bis[(N-alkylphenothiazin-3-yl)vinyl]anthracene derivatives with different propyl, hexyl, and dodecyl side chains (AnPh3, AnPh6, and AnPh12) were synthesized and confirmed by standard spectroscopic methods. All of the compounds exhibited obvious aggregation induced emission (AIE) and p...

Aggregation-enhanced emission active 9,10-bis(N-alkylcarbazol-2-yl-vinyl-2)anthracenes with changed length of N-alkyl chains (methyl, propyl, pentyl, and dodecyl) have been synthesized and their piezofluorochromic properties investigated. The results show that these homologues all exhibit remark...

In the present work, 9,10-bis(p-alkoxystyryl)anthracenes (DSA-OCn) with various length of alkyl chains (n=1–10, 12, 14, 16, 18) are synthesized and the chain length-dependent piezofluorochromic (PFC) behaviors are systematically investigated. The results show that all the long alkoxy-containing...

This paper reported the synthesis, optical and electroluminescent properties of 9,10-bis(N-methylcarbazol-3-yl-vinyl-2)anthracene (MCA). MCA could be facilely prepared by the Wittig–Horner reaction of N-methyl-3-formylcarbazole and 9,10-bis(diethoxyphosphorylmethyl)anthracene and exhibited stro...

The lithiation of 4,4′-dibromooctafluorobiphenyl with n-butyllithium to yield 4,4′-dilithiooctafluorobiphenyl and 4-lithio-4′-bromooctafluorobiphenyl as a by-product under various conditions is described. It is proposed that thermal decomposition of the lithiated products formed at low temper...

The magnitude of one bond and long-range coupling constants (nJHH and nJCH) in isomeric cyanopyridines-(1, 2, 3), methyl-(4, 5, 6, 7), 3-ethyl-(8), chloro-(9), 3-bromo-(10), acetyl-(11, 12), 5-ethoxycarbonyl-(13) and 4-(4′-pyridyl)-(14) derivatives of 2-cyanopyridines were determined in CDCl3. ...

Herein we report the development of a selective chemical sensor based on molecularly imprinted polymers (MIP) and quartz crystal microbalance (QCM) to detect isoborneol (ISO) in aqueous samples. Their response scales linearly with isoborneol concentration and exhibits sensitivity of -16.23 Hz mM...

A toxicologic and dermatologic review of isoborneol when used as a fragrance ingredient is presented.

Several Cu/ZnO/Al2O3 catalysts with high Cu and ZnO contents were used to study the influence of solvent polarity on the dehydrogenation and dehydration of isoborneol. The employment of a polar solvent enhanced the activity for the main dehydrogenation reaction, while the use of a non-polar solv...

The crotylstannation reaction: has been found to be reversible. The compounds trans/cis-Bu3-nCln SnCH2CH= CHCH3 (n = 0, 1, 2) have been prepared by elimination reactions of organostannoxy compounds,Bu3−nClnSn—O—C(Me)(i-Pr)CH(Me)CHCH2, which were synthesized by means of transalkoxylation bet...