(1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC, 4a), which is a conformationally restricted analogue of antidepressant milnacipran [(±)-1], is a new class of potent noncompetitive NMDA receptor antagonists. A series of PPDC analogues modified at the 1-phenyl moi...

Copolymer of vinylferrocene, acrylamide and 2-(diethylamino)ethyl methacrylate was synthesized by free-radical polymerization. Proton nuclear magnetic resonance and inductively coupled plasma-optical emission spectroscopy confirmed successful incorporation of ferrocene moieties in the copolymer....

Cyclic voltammetry at a glassy carbon electrode of 2,4,6-triphenylnitrobenzene (1) in DMF shows two reversible one-electron reductions. Preparative reduction of 1 yields 2,4,6-triphenylaniline under both acidic and alkaline conditions and in DMF in the presence of acetic anhydride. On reduction ...

Efficient routes to chiral 4-hydroxy-5-hexenoic acids and lactones from d-gluconic acid-δ-lactone and l-mannonic acid-γ-lactone are described. In this approach, the starting lactones are converted to 2,6-dibromo compounds that readily undergo zinc mediated elimination to generate the terminal ...

6-Azido-6-deoxy-d-galactitol and d-mannitol were obtained quantitatively via the reduction of the corresponding 6-azido-6-deoxy-d-hexono-1,4-lactones, and 6-azido-6-deoxy-d-glucitol was obtained by the reduction of 6-azido-6-deoxyglucose in good yields. The reduction of monoazidodeoxyhexitols by...

Colourless tungstate complexes of the sugar acids, l-manonnic, d-glucaric and galactaric acids have been studied in aqueous solutions. Multinuclear 13C and 183W NMR have been used to identify the structures of the complexes and the sites of chelation of each ligand. Indirect photometry has been ...

Publisher SummaryThis chapter presents a review of the synthesis, reactions, and related derivative of the gulono-1,4-lactones. The most efficient synthesis of L-gulono-1,4-lactone entails the reduction of D-glucofuranurono-6,3-lactone, which can be obtained from D-glucose. D-Gulose has also bee...

A capillary electrophoresis method has been developed for the separation of acidic monosaccharides and their corresponding 1,4-lactones in a single run without derivatisation. The controlled changes of the concentration in borate and the pH of the buffers allowed good selectivity in the separati...

The novel phthalonitrile derivatives bearing (2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy) and (2-((2-phenoxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile substituents at peripheral position were prepared by a nucleophilic displacement reaction. Cyclotetramerization of these phthalonitrile derivatives...

The effect of the lipophilic quaternary ion, tetraphenylphosphonium, on membrane potential of segments of rat small mesenteric artery and on the current in single voltage-clamped smooth muscle cells from rabbit portal vein was studied. In rat small mesenteric artery, tetraphenylphosphonium (1–3...

Recently, tetraphenylphosphonium bromide (TPPB) has been used to remove technetium from some radioactive waste streams. However, before TPPB could be approved for use it was necessary to show that TPPB and its degradation products would not have a significant detrimental effect on post-closure p...

Botrytis blight is a very destructive disease caused by Botrytis spp., infecting flowers, trees, vegetables and fruits. Twelve new compounds were prepared by the reaction of potassium N-aryl-sulfonyldithiocarbimates with Morita-Baylis-Hillman derivatives bearing phenyl and furyl groups. These ar...

Tetraphenylphosphonium montmorillonite (TPP-MMT) was prepared from an aqueous solution of tetraphenylphosphonium bromide and a bentonite consisting primarily of sodium rich montmorillonite (Na-MMT) together with minor amounts of cristobalite, quartz and nontronite. The original bentonite, the TP...

Background and objectiveOne of the main causes of bacterial resistance to antimicrobials is multidrug resistance induced by the increased efficiency of the efflux pumps. In this study we analyzed how the conditions of assay affect the efflux of indicator substrates ethidium (Et+) and tetraphenyl...

The reaction of lithium bis(trifluoromethanesulfonyl)imide with tetraphenylphosphonium bromide in water leads to the formation of tetraphenylphosphonium bis(trifluoromethanesulfonyl)imide ([PPh4+][(CF3SO2)2N−]). The obtained compound was identified by means of 1H, 13C, 19F and 31P NMR spectrosco...

A series of novel tetraphenylphosphonium cation-functionalized polyphosphazenes were successfully synthesized and employed to prepare the corresponding anion exchange membranes. The typical properties of the prepared membranes for fuel cell including swelling ratio, water uptake, ion exchange ca...

The reaction of [Co(NH2CH2CONCH2CO2)CN(en)] with formaldehyde under basic conditions leads to the formation of four products: cyano(ethylenediamine) [N-(4-carbonyl-4-hydroxymethyl-oxazolidine)glycinato]cobalt(III) ([Co(CH2OCH2NHC(CH2OH)CONCH2CO2)CN(en)]) (1), dicyanobis(ethylenediamine) {μ-N-((...

We describe a unique interaction of aromatic aldehydes with acrylonitrile, induced by iodotrichlorosilane (ITCS), which directly yields arylidene-3-aminoprop-2-enals.

Series of NiII and CuII complexes with dianionic [N2O2] ligands were synthesized and characterised applying spectroscopic and X-ray diffraction techniques. The ligands were obtained by 1:2 condensation of ethylene- and propylenediamine with malonic aldehyde derivatives (R2 = H, R1 = H or OCH3). ...

The Renin-Angiotensin System (RAS) possesses a counter-regulatory axis composed of angiotensin I converting enzyme 2 (ACE)2, angiotensin-(1-7) [Ang-(1-7)] and the Mas receptor, which opposes many AT1-receptor–mediated effects of ligand angiotensin (Ang)II. Ang-(1-7), as a ligand of the Mas rece...