N,N′-disubstituted urea-based soluble epoxide hydrolase (sEH) inhibitors are promising therapeutics for hypertension, inflammation, and pain in multiple animal models. The drug absorption and pharmacological efficacy of these inhibitors have been reported extensively. However, the drug metaboli...

Tributyl phosphate and its degradation products saturated with nitric acid and exposed to elevated temperatures lead to an accidental condition known as “reactive red oil formation”. The present study aims at elucidating the chemical pathway of this reaction in an Accelerating Rate Calorimeter...

Eight new compounds including 9′-[2-amino-3-(4″-O-methyl-α-rhamnopyranosyloxy) phenyl]nonanoic acid (1), 9′-[2-amino-3-(4″-O-methyl-α-ribopyranosyloxy)phenyl] nonanoic acid (2), 11′-[2-amino-3-(4″-O-methyl-α-rhamnopyranosyloxy)phenyl]undecanoic acid (3), 11′-[2-amino-3-(4″-O-methyl-α...

Excess tert-butyl alcohol is generally used to promote the etherification reaction for production of glycerol ether. However, the difficulty in recovering this excess alcohol is caused by the presence of an azeotropic mixture of tert-butyl alcohol and water, a by-product from the etherification....

A novel triamine (1) with tert-butyl side group, N1,N1-bis(4-aminophenyl)-4-(tert-butyl)benzene-1,3-diamine, is synthesized and then polymerized with the dianhydride 6FDA (A2) at the different feed molar ratio. Monitoring by 1H NMR spectrum, the reactivity of 3-amino group with ortho-tert-butyl ...

Viscosities of the systems of tert-butanol (TB) + n-butylamine (NBA), TB + di-n-butylamine (DBA) and TB + tri-n-butylamine (TBA) were determined at the temperatures ranging from 303.l5 to 323.15 K within the composition range 0 ≤ x2 ≤ 1, where x2 is the mole fraction of TB. The viscosity, η i...

Incubation of [14C]-ring labeled hexamethylmelamine and pentamethylmelamine with rat and mouse liver microsomal preparations results in metabolic activation of both drugs as measured by covalent binding of radiolabel to acid-precipitable microsomal macromolecules. Covalent binding is dependent o...

The central side effects of pentamethylmelamine (PMM), an antitumoral agent, were studied on brain neurotransmitters from the biochemical and behavioural points of view. PMM causes a dose-related reduction in the body temperature and motility of mice. 100 mg/kg of PMM lowers the levels of noradr...

An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-...

A versatile, facile and concise approach to access to highly substituted functionalized 2-(pyrrolidin-1-yl)thiazole ring system is accomplished. The efficient protocol proceeds by the reaction of corresponding racemic or enantiomerically enriched pyrrolidines and readily available benzoylisothio...

Let C be an (n+2)-angulated category with an n-suspension functor Σn and X be a cluster-tilting subcategory of C. Then we show that the quotient category C/X is an n-abelian category, and C/X is equivalent to an n-cluster tilting subcategory of an abelian category mod(Σ−nX). In addition, if C ...

Quantum chemistry methods were used to study the [Ag24(trz)18]n nanocage (0, +2, +4 and +6) with intention of obtaining new nanocages. Except for [Ag24(trz)18]6+, the nanocages at triplet state present lowest energy than singlet state. The large energy gap (3.75 eV) implies the higher chemical s...

Let Bn=[Bn,k]n,k⩾0 be the Bell matrix. Define the n×n shift Bell matrix Pn,k by (Pn,k)i,j=Bk+i−1,k+j−1 for i,j=1,2,⋯n and k=0,1,2⋯. In this paper, matrix factorizations of the n×n shift Bell matrix and the n×n generalized Riordan matrix are studied. As a result, many lower triangular matrices...

A Nickel(II) complex, catena-poly[bis(N-methylthiourea)bis(thiocyanato-κN)nickel(II)], [Ni(Metu)2(NCS)2]n (1) was prepared and its structure was determined by single crystal X-ray analysis. In 1, the nickel(II) ion is bound to four sulfur atoms of bridging Metu ligands and two nitrogen atoms of...

A new series of pyrazole derivatives was prepared in this work, including pyrazolopyrimidines, pyrazolotriazines, pyrazolylthienopyridines, and 2-(pyrazolylamino)thiazol-4-ones, utilizing 3-amino-5-methyl-1H-pyrazole as a synthetic precursor. Their in vitro anticancer activity was tested on hepa...

Solvent-free synthesis pathway for obtaining two imidazole derivatives (2-chloro-1-(4-methoxyphenyl)-4,5-dimethyl-1H-imidazole (CLMPDI) and 1-(4-bromophenyl)-2-chloro-4,5-dimethyl-1H-imidazole (BPCLDI) has been reported in this work, followed by detailed experimental and computational spectrosco...

Two novel imidazole derivatives, 2-chloro-4,5-dimethyl-1-phenyl-1H-imidazole (C11H11ClN2)(PHENYLI) and 2-chloro-4,5-dimethyl-1-(o-tolyl)-1H-imidazole (C12H13ClN2) (TOLYLI), have been obtained by a procedure based on solvent-free synthesis pathway. Newly synthetized imidazole derivatives have bee...

The reactivity of stereochemically defined 3-aryl-2-chloro-2-imidoylaziridines, an unexplored class of substituted aziridines, was investigated under various reaction conditions. 2-Chloro-2-imidoylaziridines underwent a novel thermal rearrangement by reflux in acetonitrile via C–C bond cleavage...

Selenium dioxide oxidations of 3-methyl-4,5,6,7-tetrafluoroindoles gave 3-formyl or 3-acetoxymethyltetrafluoroindoles in unexpectedly high selectivities, which turned out to serve as useful intermediates for the syntheses of tetrafluoro analogs of tryptophan, tryptamine and indole acetic acid.

Tetrafluoroindole (5), a precursor for potential biologically-active compounds, was prepared previously in a four-step synthesis from C6F6. However, catalytic reduction of pentafluorophenylacetonitrile (2) to 2-pentafluorophenylethyl amine (3) is accompanied by a significant amount of a secondar...