In this study, two angiotensin-converting enzyme inhibitory peptides (ACEIPs) were isolated from Trichiurus lepturus myosin by trypsin hydrolysis for 5 h, ultrafiltration, with membrane of 3 kDa molecular weight cut-off and three-stage reversed-phase high-performance liquid chromatography (RP-HP...

Native angiotensin-(1–7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1–7), termed cAng-(1–7), which is fully resistant to ACE and has strongly increased resistance to ...

The anti-plasmodium activity of angiotensin II and its analogs have been described in different plasmodium species. Here we synthesized angiotensin II Ala-scan analogs to verify peptide-parasite invasion preservation with residue replacements. The analogs were synthesized by 9-fluorenylmethoxyca...

Overall rates of polymerization of ring-substituted-N-phenylmaleimides were measured, mainly in dioxane. Rate equations were deduced. The rate of polymerization increased on addition of ZnCl2; the effect was attributed to the interaction of the Lewis acid and the π-cloud of the growing maleimid...

Based on a recent report that 1-methyl-3-phenylpyrrolyl analogues are moderately potent reversible inhibitors of the enzyme monoamine oxidase B (MAO-B), a series of structurally related N-methyl-2-phenylmaleimidyl analogues has been prepared and evaluated as inhibitors of MAO-B. In general, the ...

Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported. Compounds showed antiproliferative activity in one-digit micromolar to submicromolar concentrations. The most active derivatives toward all t...

Endometriosis is mainly characterized by the presence of endometrial tissue exterior to the uterus, however, the exact pathophysiology of this disease still remains uncertain. Moreover, the incidence significantly contributes to infertility among women and hence, a novel treatment for endometrio...

Potential of aqueous solutions of cyanocobalamin in gamma radiation dosimetry was investigated. The solutions are inexpensive, nontoxic and easy-to-prepare dosimeters, which could be useful for measuring gamma radiation doses in various applications, such as quarantine treatment of fruit or inse...

Cyanocobalamin (CNCbl) is an active form of vitamin B12, commonly employed for the preparation of multivitamin supplements and fortified food. In this study, we present a novel analytical method for its determination based on stable isotope dilution liquid chromatography electrospray tandem mass...

For increasing the aquaculture production, it is crucial to develop quality feeds with all the essential nutrients including vitamins. Since vitamins are essential nutrient required in small amount to perform structural and functional roles, information on the dietary vitamin requirements is ess...

On the basis of previous reports on the importance of thienyl, furyl or phenol group substitution on 5H-indeno[1,2-b]pyridine skeleton, a new series of rigid 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine derivatives were systematically designed and synthesized. Topoisomerase inhibitory a...

Bisphenol “A” is a widespread environmental hormone. After the prohibition on the use of BPA in some applications, it is progressively replaced by its variants. However, these variants of Bisphenol “A” are also noxious. It is therefore of the utmost importance to find the similarity among th...

Lipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were prepared in two forms, as a suspension of multilamellar spherical vesicles and as planar membranes deposited on a conductive solid support. We used Fourier Transformed Infrared (FTIR) and Raman spectroscopic techniques to ...

Development of nanomaterials has drawn interest on silver nanoparticles (AgNPs), which are being incorporated in several biomedical and environmental applications, especially anti-bacterial properties of AgNPs has intense excitement for their commercial use. However, the impact of AgNPs on cell ...

Following an initial screening of six common imidazolium, imidazolinium, and dithiolium salts in the presence of a base, 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IDip) and 1,3-dimesitylimidazolin-2-ylidene (SIMes) were identified as promising organocatalysts for the microwave-assisted s...

Current polyurethane (PU) industrial and academic research aims at developing non-isocyanate PUs, referred to as NIPUs. Within this context, we report herein the synthesis of original vinylene carbonate (VC) compounds, subsequently used as chain-transfer agents (CTAs) towards the preparation of ...

Publisher SummaryThis chapter discusses the structural changes that have been made in each of the above regions of methotrexate (MTX), the synthetic chemical methods used in preparing MTX analogs, and the fascinating structure–activity correlations made possible by the availability of these com...

Publisher SummaryThe quinoline alkaloids are derived from anthranilic acid. More than 80 new quinoline alkaloids have been isolated, a new group, the dimeric quinolinones, has been discovered, and considerable advances have been made in the synthesis of the alkaloids. Spectroscopic methods conti...

Publisher SummaryAnthranilic acid is covalently linked to agarose through several of its functional groups. Because anthranilic acid has been shown to cause significant product inhibition of anthranilate synthetase at low concentrations, the adsorption of the unaggregated form of anthranilate- P...

The emergence of multi-drug resistant (MDR) strains of Mycobacterium tuberculosis is the main reason why tuberculosis (TB) continues to be a major health problem worldwide. It is urgent to discover novel anti-mycobacterial agents based on new drug targets for the treatment of TB, especially MDR-...