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Xian Changyue Biological Technology Co., Ltd.

Diarrhea, cold blood detoxification, blood stasis. It is used for real heat constipation, the product is delayed abdominal pain, the diarrhea is not good, the humidity is hot and the jaundice, the blood is hot vomit the mouth, the eyes are red, the p

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Quality Manufacturer Supply High Purity Rhein Rhein with Reasonable Price

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Rhein Manufacturer/High quality/Best price/In stock

Cas:478-43-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Rhein supplier in China

Cas:478-43-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Specifications Type: Aloe Vera Powder Form: Powder Part: Leaf Extraction Type: gathered the yellow outflew Packaging: Drum, Vacuum P

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 478-43-3 Rhein Manufacturer

Cas:478-43-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Rhein

Cas:478-43-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Rhei Extract Powder

Cas:478-43-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Chrysazin-3-carboxylic acid

Cas:478-43-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Rhein English Name: Esculin CAS No.478-43-3 Molecular formula:C15H8O6 Molecular weight:284.21 Packaging Specification: 25kg/drum high purity 99%min stock Hubei DiBo Chemical Co., Ltd. was founded in 2009, is a high-tech industrial un

Rhein material/powder /CAS:478-43-3

Cas:478-43-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: Rhein Synonyms: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylicaci;9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaci;chrysazin-3-carboxylicacid;monorhein;rheicacid

TIANFU-CHEM Rhein

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Plant Extract Rhein CAS 478-43-3

Cas:478-43-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount priceCAS 478-43-3 with high-quality service

Cas:478-43-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Rhein 478-43-3

Cas:478-43-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

100% Natural Rhein 478-43-3 Anti-osteoarthritis

Cas:478-43-3

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

Specifications Productname:Rhein purity:98% HerbSourse:MedicinalplantsandrhubarbPolygonaceae Brief:Brownneedlecrystal … Appearance:brown Storage:dry and cool place Package:1kg/pack Application:pharma Transportation:by air ,ems Port:shanghai

Top quality Rhein nature extract

Cas:478-43-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Rhein Structure: Formula: C15H8O6 Molecular Weight : 284.22 Synonyms: chrysazin-3-carboxylicacid;monorhein;rheicacid;RHUBARB EXTRACT;RHUBARB YELLOW;RHEIN;T

Factory Supply High Quality Rhein

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Rhein/ LIDE PHARMA- Factory supply / Best price

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate Rhein CAS:478-43-3

Cas:478-43-3

Min.Order:1 Kilogram

FOB Price: $95.0 / 98.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Rhein CAS:478-43-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroi

Rhein CAS:478-43-3

Cas:478-43-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rhein

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Rhein

Cas:478-43-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Rhein

Cas:478-43-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Rhein

Cas:478-43-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Rhein

Cas:478-43-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Yellowish brown solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Found

Rhein

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Rhein

Cas:478-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

chrysazin-3-carboxylicacidCAS NO.: 478-43-3

Cas:478-43-3

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Synthetic route

diacetylrhein
13739-02-1

diacetylrhein

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sodium carbonate In water100%
Stage #1: diacetylrhein With water; sodium carbonate
Stage #2: With hydrogenchloride In water pH=2;
100%
With sodium hydroxide In water for 0.5h;60%
Chrysophanol
481-74-3

Chrysophanol

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
Stage #1: Chrysophanol With chromium(VI) oxide In acetic anhydride; acetic acid at 65℃; for 8h;
Stage #2: With sodium carbonate In water
98%
Stage #1: Chrysophanol With pyridine at 20℃;
Stage #2: With chromium(VI) oxide; acetic anhydride; acetic acid In water at 45 - 65℃; for 8h;
98%
Rhein methyl ester
6155-37-9

Rhein methyl ester

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran for 0.5h;96%
1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione
481-72-1

1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With oxygen at 120℃; for 14h; Green chemistry;93%
With sulfuric acid; sodium nitrite at 120℃; for 3h;85%
With water; pyridinium chlorochromate In N,N-dimethyl-formamide at 20℃; for 24h;62%
4-(2-methoxybenzoyl)-5-methoxybenzene-1,3-dicarboxylic acid
1019637-61-6

4-(2-methoxybenzoyl)-5-methoxybenzene-1,3-dicarboxylic acid

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
at 155 - 160℃; for 14h; Inert atmosphere;92%
rhein potassium
1402610-53-0

rhein potassium

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sulfuric acid In water pH=4.5 - 5;87%
Ethyl 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylate
109650-18-2

Ethyl 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylate

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sodium hydroxide for 24h; Ambient temperature;85%
C21H21OO4N

C21H21OO4N

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With hydrogenchloride at 120℃; for 120h;74%
3-carboxy-1,8-dimethoxyanthracene-9,10-dione
72049-24-2

3-carboxy-1,8-dimethoxyanthracene-9,10-dione

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With hydrogen bromide In toluene for 10h; Reflux;56%
5-hydroxy-4-(2-hydroxybenzoyl)isophthalic acid
820243-51-4

5-hydroxy-4-(2-hydroxybenzoyl)isophthalic acid

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With aluminium trichloride; sodium chloride at 150℃; for 2h;50%
1,8,9-triacetoxy-3-methyl-anthracene
61446-06-8

1,8,9-triacetoxy-3-methyl-anthracene

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

sennidin B
517-44-2

sennidin B

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
(+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid
517-44-2, 641-12-3, 57762-62-6, 67479-20-3, 98461-42-8

(+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
sennidin A-8-monoglucoside
82334-26-7, 82373-27-1, 111144-51-5

sennidin A-8-monoglucoside

A

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

B

sennidin B
517-44-2

sennidin B

Conditions
ConditionsYield
With supernatant fluid of rat feces at 37℃; for 2h; Product distribution; anaerobic incubation;
4-Acetoxy-5,9-dimethoxy-anthracene-2-carboxylic acid ethyl ester
155500-91-7

4-Acetoxy-5,9-dimethoxy-anthracene-2-carboxylic acid ethyl ester

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With chromium(VI) oxide; hydrogen bromide 1.) AcOH,; Yield given. Multistep reaction;
4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde

4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sulfuric acid; bromine 1.) H2O; Yield given; Multistep reaction;
rhein-11-O-β-D-glucoside
67565-95-1

rhein-11-O-β-D-glucoside

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 1h; Hydrolysis; Heating;4 mg
(+)-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

(+)-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With water; iron(III) chloride
aloeemodin

aloeemodin

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
barbaloin

barbaloin

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With chromic acid
With chromic acid Acetylieren des Oxydationsproduktes und Auskochen des Acetylierungsproduktes mit Benzol, man verseift mit verd. Kalilauge;
chrysophanic acid diacetate

chrysophanic acid diacetate

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With acetic anhydride; chromic acid; acetic acid Behandeln des entstandenen Rheindiacetats mit Kalilauge;
chrysophanic acid dibenzoate

chrysophanic acid dibenzoate

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione
481-72-1

1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione

acetic acid
64-19-7

acetic acid

CrO2

CrO2

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

meso-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

meso-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
With water; iron(III) chloride
8-O-β-D-glucosyl-10-C-β-D-glucosyl rhein-9-anthrone
111545-29-0, 111614-11-0

8-O-β-D-glucosyl-10-C-β-D-glucosyl rhein-9-anthrone

A

D-Glucose
2280-44-6

D-Glucose

B

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

C

arabinose

arabinose

Conditions
ConditionsYield
With sulfuric acid; iron(III) chloride for 0.5h; Product distribution; Heating;
8-O-β-D-gucosyl-10-hydroxy-10-β-D-gycosyl rhein-9-anthrone
111545-28-9, 111614-10-9

8-O-β-D-gucosyl-10-hydroxy-10-β-D-gycosyl rhein-9-anthrone

A

D-Glucose
2280-44-6

D-Glucose

B

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

C

arabinose

arabinose

Conditions
ConditionsYield
With sulfuric acid; iron(III) chloride for 0.5h; Product distribution; Heating;
(2,4-dibromo-6-hydroxyphenyl)-(2-hydroxyphenyl)methanone
820243-52-5

(2,4-dibromo-6-hydroxyphenyl)-(2-hydroxyphenyl)methanone

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 87 percent / K2CO3 / dimethylformamide / 12 h / 80 °C
2: 92 percent / Et3N; (dppf)PdCl2; dppf / dimethylformamide / 18 h / 80 °C / 750.06 Torr
3: KOH / methanol / 48 h / 60 °C
4: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr
5: 50 percent / AlCl3; NaCl / 2 h / 150 °C
View Scheme
(2-benzyloxy-4,6-dibromophenyl)-(2-benzyloxyphenyl)methanone
820243-54-7

(2-benzyloxy-4,6-dibromophenyl)-(2-benzyloxyphenyl)methanone

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / Et3N; (dppf)PdCl2; dppf / dimethylformamide / 18 h / 80 °C / 750.06 Torr
2: KOH / methanol / 48 h / 60 °C
3: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr
4: 50 percent / AlCl3; NaCl / 2 h / 150 °C
View Scheme
5-benzyloxy-4-(2-benzyloxybenzoyl)isophthalic acid dimethyl ester
820243-55-8

5-benzyloxy-4-(2-benzyloxybenzoyl)isophthalic acid dimethyl ester

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH / methanol / 48 h / 60 °C
2: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr
3: 50 percent / AlCl3; NaCl / 2 h / 150 °C
View Scheme
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

acetic anhydride
108-24-7

acetic anhydride

diacetylrhein
13739-02-1

diacetylrhein

Conditions
ConditionsYield
With pyridine; dmap100%
With dmap; triethylamine In acetic anhydride at 20℃; for 1h;95%
With pyridine at 120℃; for 6h;93%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

2-azidoethyl derivative

2-azidoethyl derivative

C21H17N9O6

C21H17N9O6

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 2-azidoethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

2-methoxyethyl derivative

2-methoxyethyl derivative

C24H26O9

C24H26O9

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 2-methoxyethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

3-methoxypropyl derivative

3-methoxypropyl derivative

C27H32O9

C27H32O9

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 3-methoxypropyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

allyl derivative

allyl derivative

BW-AQ-152
1537900-61-0

BW-AQ-152

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: allyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

benzyl derivative

benzyl derivative

1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester
1537900-58-5

1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: benzyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

ethyl derivative

ethyl derivative

4,5-Diethoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, ethyl ester

4,5-Diethoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, ethyl ester

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: ethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

isobutyl derivative

isobutyl derivative

C27H32O6
1537900-69-8

C27H32O6

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: isobutyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

isopentyl derivative

isopentyl derivative

C30H38O6
1537900-73-4

C30H38O6

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: isopentyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

methyl derivative

methyl derivative

methyl 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
6211-34-3

methyl 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: methyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

propyl derivative

propyl derivative

BW-AQ-147
1537900-55-2

BW-AQ-147

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: propyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;
100%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

methyl iodide
74-88-4

methyl iodide

Rhein methyl ester
6155-37-9

Rhein methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80℃;93%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃;84%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

ethylene glycol
107-21-1

ethylene glycol

2-hydroxyethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
1174523-49-9

2-hydroxyethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 85℃; for 1h;92%
With sulfuric acid In toluene at 85℃; for 5h;72%
With sulfuric acid at 80 - 90℃;
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

benzyl chloride
100-44-7

benzyl chloride

1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester
1537900-58-5

1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere;92%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere;92%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere;92%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

6-bromohexyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

6-bromohexyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;91.6%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;90.6%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;89.8%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate

α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](2-methoxyphenyl)methyl}phosphonate
1537944-47-0

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](2-methoxyphenyl)methyl}phosphonate

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h;
Stage #2: α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;
90%
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol at 20℃; for 0.166667h; Cooling with ice;
Stage #2: α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate In methanol; N,N-dimethyl-formamide at 35℃; for 4h;
90%
1,5-dibromo-pentane
111-24-0

1,5-dibromo-pentane

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

5-bromopentyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

5-bromopentyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;89.8%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

4-bromobutyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

4-bromobutyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;89.2%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;89.2%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate
110470-34-3, 110548-53-3, 110548-54-4, 112564-56-4

diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](4-methoxyphenyl)methyl}phosphonate
1537944-50-5

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](4-methoxyphenyl)methyl}phosphonate

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h;
Stage #2: diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;
89%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 20 - 60℃; for 3h; Cooling with ice;89%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

diethylene glycol
111-46-6

diethylene glycol

2-(2-hydroxyethoxy)ethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
1174523-50-2

2-(2-hydroxyethoxy)ethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 85℃; for 1h;88%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

α-O,O'-diethyl amino(3-fluorophenyl)methylphosphonate
1005517-85-0

α-O,O'-diethyl amino(3-fluorophenyl)methylphosphonate

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](3-fluorophenyl)methyl}phosphonate
1537944-53-8

O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](3-fluorophenyl)methyl}phosphonate

Conditions
ConditionsYield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h;
Stage #2: α-O,O'-diethyl amino(3-fluorophenyl)methylphosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;
88%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol; dimethyl sulfoxide at 10 - 20℃; for 5h; Cooling with ice;88%
1,8-dihydroxy-3-carboxy-anthraquinone
478-43-3

1,8-dihydroxy-3-carboxy-anthraquinone

1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

3-bromopropyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

3-bromopropyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;87.7%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18.08h;87.5%
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