Rhein supplier | CasNO.478-43-3

Name
Rhein
EINECS 207-521-4
CAS No. 478-43-3
Article Data48
CAS DataBase
Density 1.687 g/cm³
Solubility <0.1 g/100 mL at 17 °C in water
Melting Point ≥300 °C(lit.)
Formula C₁₅H₈O₆
Boiling Point 597.8 °C at 760 mmHg
Molecular Weight 284.225
Flash Point 329.4 °C
Transport Information
Appearance Yellowish brown solid
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Monorhein;4,5-DiOH-anthraquinone-2-COOH;Chrysazin-3-carboxylic acid;Rhein (1,8-dihydroxy-3-carboxyl anthraquinone);4, 5-Dihydroxyanthraquinone-2-carboxylic acid;Rheic acid;9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid;Rhubarb Yellow;1.8-Dihydroxy-3-Carboxy anthraquinone;4-10-00-04088 (Beilstein Handbook Reference);2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (8CI);4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylate;Cassic acid;2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-;2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-;1,8-Dihydroxyanthraquinone-3-carboxylic acid;9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid;4,5-Dihydroxy-2-anthraquinonecarboxylic acid;
PSA 111.90000
LogP 1.57140

Synthetic route

: 13739-02-1
diacetylrhein

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sodium carbonate In water	100%
Stage #1: diacetylrhein With water; sodium carbonate Stage #2: With hydrogenchloride In water pH=2;	100%
With sodium hydroxide In water for 0.5h;	60%

: 481-74-3
Chrysophanol

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
Stage #1: Chrysophanol With chromium(VI) oxide In acetic anhydride; acetic acid at 65℃; for 8h; Stage #2: With sodium carbonate In water	98%
Stage #1: Chrysophanol With pyridine at 20℃; Stage #2: With chromium(VI) oxide; acetic anhydride; acetic acid In water at 45 - 65℃; for 8h;	98%

: 6155-37-9
Rhein methyl ester

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran for 0.5h;	96%

: 481-72-1
1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With oxygen at 120℃; for 14h; Green chemistry;	93%
With sulfuric acid; sodium nitrite at 120℃; for 3h;	85%
With water; pyridinium chlorochromate In N,N-dimethyl-formamide at 20℃; for 24h;	62%

: 1019637-61-6
4-(2-methoxybenzoyl)-5-methoxybenzene-1,3-dicarboxylic acid

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
at 155 - 160℃; for 14h; Inert atmosphere;	92%

: 1402610-53-0
rhein potassium

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sulfuric acid In water pH=4.5 - 5;	87%

: 109650-18-2
Ethyl 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylate

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sodium hydroxide for 24h; Ambient temperature;	85%

: C21H21OO4N

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With hydrogenchloride at 120℃; for 120h;	74%

: 72049-24-2
3-carboxy-1,8-dimethoxyanthracene-9,10-dione

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With hydrogen bromide In toluene for 10h; Reflux;	56%

: 820243-51-4
5-hydroxy-4-(2-hydroxybenzoyl)isophthalic acid

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With aluminium trichloride; sodium chloride at 150℃; for 2h;	50%

: 61446-06-8
1,8,9-triacetoxy-3-methyl-anthracene

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 517-44-2
sennidin B

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 517-44-2, 641-12-3, 57762-62-6, 67479-20-3, 98461-42-8
(+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 82334-26-7, 82373-27-1, 111144-51-5
sennidin A-8-monoglucoside

A: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

B: 517-44-2
sennidin B

C: 517-44-2, 641-12-3, 57762-62-6, 67479-20-3, 98461-42-8
sennidin A

Conditions

Conditions	Yield
With supernatant fluid of rat feces at 37℃; for 2h; Product distribution; anaerobic incubation;

...Expand

: 155500-91-7
4-Acetoxy-5,9-dimethoxy-anthracene-2-carboxylic acid ethyl ester

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With chromium(VI) oxide; hydrogen bromide 1.) AcOH,; Yield given. Multistep reaction;

: 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sulfuric acid; bromine 1.) H2O; Yield given; Multistep reaction;

: 67565-95-1
rhein-11-O-β-D-glucoside

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 1h; Hydrolysis; Heating;	4 mg

(+)-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2'): (+)-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With water; iron(III) chloride

aloeemodin: aloeemodin

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

barbaloin: barbaloin

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With chromic acid
With chromic acid Acetylieren des Oxydationsproduktes und Auskochen des Acetylierungsproduktes mit Benzol, man verseift mit verd. Kalilauge;

chrysophanic acid diacetate: chrysophanic acid diacetate

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With acetic anhydride; chromic acid; acetic acid Behandeln des entstandenen Rheindiacetats mit Kalilauge;

chrysophanic acid dibenzoate: chrysophanic acid dibenzoate

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 481-72-1
1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione

: 64-19-7
acetic acid

CrO2: CrO2

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

...Expand

meso-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2'): meso-4,4'-dihydroxy-5,5'-di-D-glucopyranosyloxy-10,10'-dioxo-9,10,9',10'-tetrahydro-<9,9'>bianthryl-dicarboxylic acid-(2,2')

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
With water; iron(III) chloride

: 111545-29-0, 111614-11-0
8-O-β-D-glucosyl-10-C-β-D-glucosyl rhein-9-anthrone

A: 2280-44-6
D-Glucose

B: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

C arabinose: arabinose

Conditions

Conditions	Yield
With sulfuric acid; iron(III) chloride for 0.5h; Product distribution; Heating;

...Expand

: 111545-28-9, 111614-10-9
8-O-β-D-gucosyl-10-hydroxy-10-β-D-gycosyl rhein-9-anthrone

A: 2280-44-6
D-Glucose

B: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

C arabinose: arabinose

Conditions

Conditions	Yield
With sulfuric acid; iron(III) chloride for 0.5h; Product distribution; Heating;

...Expand

: 820243-52-5
(2,4-dibromo-6-hydroxyphenyl)-(2-hydroxyphenyl)methanone

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 87 percent / K2CO3 / dimethylformamide / 12 h / 80 °C 2: 92 percent / Et3N; (dppf)PdCl2; dppf / dimethylformamide / 18 h / 80 °C / 750.06 Torr 3: KOH / methanol / 48 h / 60 °C 4: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr 5: 50 percent / AlCl3; NaCl / 2 h / 150 °C View Scheme

: 820243-54-7
(2-benzyloxy-4,6-dibromophenyl)-(2-benzyloxyphenyl)methanone

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 92 percent / Et3N; (dppf)PdCl2; dppf / dimethylformamide / 18 h / 80 °C / 750.06 Torr 2: KOH / methanol / 48 h / 60 °C 3: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr 4: 50 percent / AlCl3; NaCl / 2 h / 150 °C View Scheme

: 820243-55-8
5-benzyloxy-4-(2-benzyloxybenzoyl)isophthalic acid dimethyl ester

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: KOH / methanol / 48 h / 60 °C 2: 414 mg / H2 / Pd/C / ethanol / 12 h / 20 °C / 750.06 Torr 3: 50 percent / AlCl3; NaCl / 2 h / 150 °C View Scheme

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 108-24-7
acetic anhydride

: 13739-02-1
diacetylrhein

Conditions

Conditions	Yield
With pyridine; dmap	100%
With dmap; triethylamine In acetic anhydride at 20℃; for 1h;	95%
With pyridine at 120℃; for 6h;	93%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

2-azidoethyl derivative: 2-azidoethyl derivative

: C21H17N9O6

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 2-azidoethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

2-methoxyethyl derivative: 2-methoxyethyl derivative

: C24H26O9

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 2-methoxyethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

3-methoxypropyl derivative: 3-methoxypropyl derivative

: C27H32O9

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 3-methoxypropyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

allyl derivative: allyl derivative

: 1537900-61-0
BW-AQ-152

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: allyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

benzyl derivative: benzyl derivative

: 1537900-58-5
1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: benzyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

ethyl derivative: ethyl derivative

: 4,5-Diethoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, ethyl ester

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: ethyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

isobutyl derivative: isobutyl derivative

: 1537900-69-8
C27H32O6

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: isobutyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

isopentyl derivative: isopentyl derivative

: 1537900-73-4
C30H38O6

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: isopentyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

methyl derivative: methyl derivative

: 6211-34-3
methyl 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: methyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

propyl derivative: propyl derivative

: 1537900-55-2
BW-AQ-147

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: propyl derivative With sodium iodide In N,N-dimethyl-formamide at 60 - 70℃;	100%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 74-88-4
methyl iodide

: 6155-37-9
Rhein methyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80℃;	93%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃;	84%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 107-21-1
ethylene glycol

: 1174523-49-9
2-hydroxyethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With sulfuric acid at 85℃; for 1h;	92%
With sulfuric acid In toluene at 85℃; for 5h;	72%
With sulfuric acid at 80 - 90℃;

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 100-44-7
benzyl chloride

: 1537900-58-5
1,8-dibenzyloxy-9,10-anthraquinone-3-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere;	92%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere;	92%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere;	92%

: 629-03-8
1 ,6-dibromohexane

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 6-bromohexyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;	91.6%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;	90.6%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;	89.8%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate

: 1537944-47-0
O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](2-methoxyphenyl)methyl}phosphonate

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h; Stage #2: α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;	90%
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol at 20℃; for 0.166667h; Cooling with ice; Stage #2: α-O,O'-diethyl amino(2-methoxyphenyl)methylphosphonate In methanol; N,N-dimethyl-formamide at 35℃; for 4h;	90%

: 111-24-0
1,5-dibromo-pentane

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 5-bromopentyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;	89.8%

: 110-52-1
1,4-dibromo-butane

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 4-bromobutyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;	89.2%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18h;	89.2%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 110470-34-3, 110548-53-3, 110548-54-4, 112564-56-4
diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate

: 1537944-50-5
O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](4-methoxyphenyl)methyl}phosphonate

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h; Stage #2: diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;	89%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 20 - 60℃; for 3h; Cooling with ice;	89%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 111-46-6
diethylene glycol

: 1174523-50-2
2-(2-hydroxyethoxy)ethyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With sulfuric acid at 85℃; for 1h;	88%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 1005517-85-0
α-O,O'-diethyl amino(3-fluorophenyl)methylphosphonate

: 1537944-53-8
O,O'-diethyl {[2-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetylamino](3-fluorophenyl)methyl}phosphonate

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxy-3-carboxy-anthraquinone With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 0℃; for 0.25h; Stage #2: α-O,O'-diethyl amino(3-fluorophenyl)methylphosphonate In dimethyl sulfoxide at 0 - 20℃; for 5h;	88%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol; dimethyl sulfoxide at 10 - 20℃; for 5h; Cooling with ice;	88%

: 478-43-3
1,8-dihydroxy-3-carboxy-anthraquinone

: 109-64-8
1,3-dibromo-propane

: 3-bromopropyl 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃;	87.7%
With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 20℃; for 18.08h;	87.5%

Rhein Chemical Properties

IUPAC Name:4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
Molecular Formula:C₁₅H₈O₆
Molecular Weight:284.220420 g/mol
Melting Point:≥300 °C(lit.)
storage temp.:2-8°C
Water Solubility:<0.1 g/100 mL at 17°C
Merck:13,8260
CAS DataBase Reference:478-43-3(CAS DataBase Reference)
EPA Substance Registry System:478-43-3(EPA Substance)
Synonyms of RHUBARB YELLOW(478-43-3):
9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylicaci;9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaci;chrysazin-3-carboxylicacid;monorhein;rheicacid;RHUBARBEXTRACT;RHUBARB YELLOW;RHEIN
Categories of RHUBARB YELLOW(478-43-3):
Anthraquinones, Hydroquinones and Quinones;Aromatics Compounds;Improve Organism Immunity;The group of Polydatin;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds

Rhein Uses

RHUBARB YELLOW(478-43-3) is used as a pharmaceutical intermediate and health food ingredient.

Rhein Toxicity Data With Reference

1.		orl-mus LD50:>5 g/kg		PHTOEH Pharmacology and Toxicology (Copenhagen). 61 (1987),153.
2.		ivn-mus LD50:>25 mg/kg		PHTOEH Pharmacology and Toxicology (Copenhagen). 61 (1987),153.

Rhein Safety Profile

Safety Information of RHUBARB YELLOW(478-43-3):
Hazard Codes:Xi

Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39:Wear suitable gloves and eye/face protection
WGK Germany:2
RTECS:CA9516000
A poison by intravenous route. Low toxicity by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.

Product Name

Rhein

Synthetic route

Rhein Chemical Properties

Rhein Uses

Rhein Toxicity Data With Reference

Rhein Safety Profile

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