Aberrant interactions of metal ions with amyloid-β peptide (Aβ) can potentiate Alzheimer's disease (AD) by participating in the aggregation process of Aβ and in the generation of reactive oxygen species (ROS). Metallothionein-3 (MT3), which is aberrantly expressed in AD brains, is believ...

BackgroundAlzheimer's disease (AD) biomarkers, such as cerebrospinal fluid (CSF) amyloid-β (1–42; Aβ42), can provide high diagnostic accuracy. Several immunoassays are available for Aβ42 quantitation, but standardisation across assays remains an issue. We compared the Elecsys® β-Amyloi...

This paper describes the synthesis of graft copolymers with a main chain of acrylic nature; the grafts attached to the backbone are composed of a biodegradable polyester, poly(glycolic acid), with well-known applications in medicine. The synthesis has been carried out by radical polymerisation o...

Poly(2-oxazoline)s have been investigated for decades as biomaterials. Pioneering early work suggested that hydrophilic poly(2-oxazoline)s are comparable to poly(ethylene glycol) regarding their potential as biomaterials, but the ready commercial availability of the latter has led to its meteori...

While sharing common biological activity, the two endogenous ligands of the G protein-coupled receptor UT, e.g. urotensin II (UII) and urotensin II-related peptide (URP), also exhibit distinct effects that could be explained by distinct interactions with their cognate receptor (UT). Accordingly,...

Copper(II) complex of an N-octylated bis-benzimidazolyl ligand is synthesized and characterized. X-ray diffraction study revealed that copper(II) is in a distorted square-planar environment of two benzimidazolyl imine nitrogens and two nitrato ligands. This complex carries out the oxidation of 2...

Four 3D coordination polymers {[Zn(bib)(ndc)]·0.25H2O}n (1), [Cd(bix)(ndc)]n (2), [Cd(bix)(mbda)]n (3) and [Cu(bix)0.5(glu)]n (4) were synthesized and characterized (bib = 1,4-bis(2-methyl-imidazol-1-yl)butane, bix = 1,4-bis(2-methyl-imidazol-1-methyl)benzene, H2ndc = 1,4-naphthalenedicarboxyli...

[1,3]-Dipolar cycloadditions of N-aryl sydnones to benzothiophene 1,1-dioxide, 1-cyclopropylprop-2-yn-1-ol and 1-(prop-2-ynyl)indole gave fused pyrazole derivatives when carried out in refluxing toluene. While the first two dipolarophiles gave single regioisomers, this indolic derivative gave mi...

The host-guest interaction of a 7-hydroxycoumarin (3-[2-(diethylamino)ethyl]-7-hydroxy-4-methylcoumarin, 3ED4MU) with cucurbit[7]uril, CB7, was investigated in aqueous solution. From the steady-state fluorescence Job plot and 1H NMR spectroscopy the formation of a 1:1 inclusion complex, with a b...

A healthy diet depends on the daily intake of vegetables. Yet, their environmental impacts along the full supply chains are scarcely known. Therefore, this paper provides for the first time a comprehensive evaluation of the life cycle environmental impacts of vegetables consumed in UK. The impac...

BackgroundIn 2015-16, the National Health Service (NHS) Litigation Authority received 10,965 claims for clinical negligence, with surgery having the highest number of claims. Currently a sum amounting to 25% of the annual NHS budget has been ring-fenced to meet extant claims. Claims made on a ba...

On a population basis, there is a gradual decline in vitamin D status (plasma 25(OH)D) throughout winter. We developed a mathematical model to predict the population winter plasma 25(OH)D concentration longitudinally, using age-specific values for 25(OH)D expenditure (25(OH)D3 t1/2), cross-secti...

Access to decent work is an important goal for policymakers and for individuals navigating their working lives. Decent work is a career goal for individuals and a priority for many employers and policy makers seeking to promote social justice. Decent work forms part of the United Nations sustain...

One of the first pieces of legislation addressing the UK's departure from the EU/Euratom to complete its passage through Parliament is the Nuclear Safeguards Act 2018, which will enable the government to establish a domestic nuclear safeguards regime. This was driven by the need to prevent ...

This article seeks to assess the prospects of UK forensic science and technology in a post-Brexit world by analysing four interlocking issues: Brexit itself, the evolution of national criminal justice organisational and funding priorities, the increasing interrelationship of science and technolo...

One response to the major societal challenge of financial exclusion in the United Kingdom (UK) is microcredit lending for enterprise. Typically delivered via Community Development Finance Institutions (CDFIs) in the UK, these lending institutions can be conceptualised as ‘alternative’ economic...

Over the last decade or so, access to broadband services has become increasingly important. While many in the UK already benefit from the provision of broadband, some, especially those located in more rural and remote areas, do not – they may not be able to access the Internet and when they do,...

There is a lack of research into 25-hydroxyvitamin D (25(OH)D) status, light exposure and sleep patterns in South Asian populations. In addition, results of research studies are conflicting as to whether there is an association between 25(OH)D status and sleep quality.We investigated 25(OH)D sta...

We report the electrochemical determination of anti-tuberculosis drug, isoniazid (INH) using gold–platinum core–shell nanoparticles ([email protected]) modified glassy carbon electrode (GCE). The [email protected] modified GCE was fabricated by electroless deposition of AuNPs by reducing HAuCl...

A new mononuclear of copper (II), [Cu(theophylline)2(H2O)3]·2H2O, has been synthesized by reaction of theophylline (1,3-dimethyl-7H-purine-2,6-dione) with copper (II) nitrate in water. Further, its nanocomplex has been prepared through the three different methods including sonication, grinding,...